PEG-related polymer resins as synthetic supports

Wang, Zheng; Yang, Rulei; Zhu, Jingjing; Zhu, Xiaoxia

doi:10.1007/s11426-010-4022-z

Cited by 13 publications

(2 citation statements)

References 82 publications

(65 reference statements)

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“…In order to achieve the desired properties, we have selected poly(ethylene glycol) (PEG) as graing material because PEG is chemically inert and robust which can impart hydrophilic character in to the polymer supports and are extensively exploited in different synthetic transformations. 11 The optimum reaction conditions were achieved by graing two different chain lengths of PEG having molar masses 400 Da and 1500 Da. The lyophilized chloro ethyl G 3 dendrimer resins were independently subjected to Williamson's etherication with PEG molecules in dry THF under low pressure of N 2 atm in an overnight reaction.…”

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confidence: 99%

A class of linker free amphiphilic PEG grafted polymer support for linear and cyclic peptides

Siyad

Kumar

2014

RSC Adv.

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confidence: 99%

A class of linker free amphiphilic PEG grafted polymer support for linear and cyclic peptides

Siyad

Kumar

2014

RSC Adv.

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“…The poly(ethylene glycol) (PEG)-related polymer resins have advantages including good compatibilities with polar solvents, good solvent absorbency and swelling properties compared to the Merrifield resins. Zhu reviewed primarily on the more recent work in the field of developing PEG-related polymer resins as supports for organic synthesis [37].…”

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Focus on polymer chemistry papers in Science China Chemistry of the year 2010

2011

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The journal Science China Chemistry published 63 papers in polymer fields in 2010, leading to a percentage increase of 473% compared to the year 2008 and 70% to the year 2009, respectively (Figure 1). In this year, three polymer Special Topics were designed and published: Biomedical Polymer (Number 3) [1], Advances in Principles of Polymerization (Number 8) [2] and Highly Branched Polymers-Promising Architectural Macromolecules (Number 12) [3]. Several high qualified papers were published and great achievements have been obtained in the year 2010.The Special Topic of Biomedical Polymers was organized by Prof. GAO ChangYou and GU ZhongWei. According to these papers one knows that the applications of biomedical polymers are focusing on drug release [4-8] and gene delivery [9,10]. For the drug release system, a great number of materials can be utilized such as supermolecule, block copolymers, hyperbranched polymers, etc. Yan et al. synthesized a series of hyperbranched copolymers and explored their applications, especially in drug release [4,11,12].In their researches, two kinds of novel temperature-responsive hyperbranched multiarm copolymers were successfully synthesized via the atom transfer radical polymerization (ATRP). Poly(3-ethyl-3-(hydroxymethyl) oxetane) (HBPO) core and thermosensitive poly(N-isopropylacrylamide) (PNIPAM) arms were synthesized from NIPAM monomers by using a hyperbranched HBPO macroinitiator. Moreover, poly(L-lactide) (PLA) inner-shell and poly(ethylene glycol) (PEG) outer-shell with disulfide-linkages between the hydrophobic and hydrophilic moieties was developed as unimolecular micelles. The HBPO-star-PNIPAM self-assembled micelles showed much improved drug encapsulation efficiencies and temperature-dependent sustainable release behavior due to the special micellar structure. The micelles exhibited no apparent cytotoxicity against human HeLa cells. The H40-star-PLA-SS-PEG bioreducible unimolecular micelles were proved as promising carriers for the triggered intracellular delivery of hydrophobic anticancer drugs. Gu's review discussed peptide dendrimers synthesis and functionalization and their applications in biomedicine for drug release and gene delivery [13]. There are two main advantages of the peptide dendrimers, i.e. the size controllable synthesis even to nanometers and the good biocompatibility due to their similar properties as proteins. Therefore, the peptide dendrimers have received considerable attention in biomedicine. They also investigated a novel supramolecular nanoparticle, and studied the drug release behavior and the anti-tumor effects. The results demonstrate that the supramolecular nanoparticles are biocompatible and are promising carriers for drug delivery. Zhang et al. discussed several kinds of stimulus-responsive nanoparticles, including pH-responsive, temperature-responsive, lightresponsive, magnetic-responsive, ultrasound-responsive, pH/

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Ethylene Oxide Polymers: Synthesis, Modification, Topology, and Applications

Shen

Wang

2018

Encyclopedia of Polymer Science and Technology

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This article reviews the synthesis, modification, topology, and applications of ethylene oxide polymers (PEGs). The synthetic strategies presented involve the anionic ring‐opening polymerization, cationic ring‐opening polymerization, coordination polymerization, aluminum‐activated polymerization, and metal‐free polymerization. The modification concerns the m PEG derivatives, telechelic and heterotelechelic PEG. PEGs topologies discussed are focused on the block, star‐shaped, hyperbranched, and dendrimer‐like polymers. Based on the well‐defined modification and topology construction of PEGs, their applications in bioconjugation (or PEGylation) and pharmaceutical field, as well as in solid electrolyte, separation science, and support resins are presented. The article aims to help the readers to comprehensively understand the recent progress on PEGs and motivate further interest on these “evergreen” polymers.

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PEG-related polymer resins as synthetic supports

Cited by 13 publications

References 82 publications

A class of linker free amphiphilic PEG grafted polymer support for linear and cyclic peptides

A class of linker free amphiphilic PEG grafted polymer support for linear and cyclic peptides

Focus on polymer chemistry papers in Science China Chemistry of the year 2010

Ethylene Oxide Polymers: Synthesis, Modification, Topology, and Applications

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