PEG-free pH-Responsive Thermogels Containing Amphiphilic Polycationic Polyethylenimine Copolymers

Lin, Qianyu; Lim, Chen Chuan; Owh, Cally; Wong, Joey Hui Min; Ow, Valerie; Sim, Belynn; Boo, Yi Jian; Yew, Michelle P. Y.; Leow, Yi Hao; Guo, Liangfeng; Lim, Jason Y. C.; Loh, Xian Jun

doi:10.1021/acs.macromol.3c01600

Cited by 5 publications

(2 citation statements)

References 64 publications

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“…Further, they can interact with hydrophobic tissues to form stable structures that provide support and protection. 12 Thus, amphiphilic thermogels represent an important advancement in the field of hydrogels, offering more possibilities for wound repair and other biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Injectable thermogel constructed from self-assembled polyurethane micelle networks for 3D cell culture and wound treatment

Wang,

Sheng,

Wang

et al. 2024

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Injectable thermogel constructed from self-assembled polyurethane micelle networks for 3D cell culture and wound treatment

Wang,

Sheng,

Wang

et al. 2024

J. Mater. Chem. B

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“…Moreover, ferrocene (Fc), a common redox-responsive compound, can act as a hydrophobic guest for β-CD in its reduced state and undergo a reversible one-electron oxidation. 49–54 For example, an electroactive supramolecular gel has been fabricated through the host–guest interaction between β-CD and Fc, in which the reversible sol–gel phase transition can be triggered by various stimuli, such as chemical redox, applied voltage and temperature. 55 Notably, the redox and electro-responsive properties make Fc suitable in the application of control release.…”

Section: Introductionmentioning

confidence: 99%

A quadruple-stimuli responsive supramolecular hydrogel constructed from a poly(acrylic acid) derivative and β-cyclodextrin dimer

Yan,

Wang,

et al. 2024

Soft Matter

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Polyurea‐urethane Temperature‐responsive Hydrogels for Sustained Delivery of Anti‐VEGF Therapeutics

Loh,

Lin,

Zhao

et al. 2024

Chemistry An Asian Journal

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Temperature‐responsive hydrogels, or thermogels, have emerged as a leading platform for sustained delivery of both small molecule drugs and macromolecular biologic therapeutics. Although thermogel properties can be modulated by varying the polymer’s hydrophilic‐hydrophobic balance, molecular weight and degree of branching, varying the supramolecular donor‐acceptor interactions on the polymer remains surprisingly overlooked. Herein, to study the influence of enhanced hydrogen bonding on thermogelation, we synthesized a family of amphiphilic polymers containing urea and urethane linkages using quinuclidine as an organocatalyst. Our findings showed that the presence of strongly hydrogen bonding urea linkages significantly enhanced polymer hydration in water, in turn affecting hierarchical polymer self‐assembly and macroscopic gel properties such as sol‐gel phase transition temperature and gel stiffness. Additionally, analysis of the sustained release profiles of Aflibercept, an FDA‐approved protein biologic for anti‐angiogenic treatment, showed that urea bonds on the thermogel were able to significantly alter the drug release mechanism and kinetics compared to usage of polyurethane gels of similar composition and molecular weight. Our findings demonstrate the unrealized possibility of modulating gel properties and outcomes of sustained drug delivery through judicious variation of hydrogen bonding motifs on the polymer structure.

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PEG-free pH-Responsive Thermogels Containing Amphiphilic Polycationic Polyethylenimine Copolymers

Cited by 5 publications

References 64 publications

Injectable thermogel constructed from self-assembled polyurethane micelle networks for 3D cell culture and wound treatment

Injectable thermogel constructed from self-assembled polyurethane micelle networks for 3D cell culture and wound treatment

A quadruple-stimuli responsive supramolecular hydrogel constructed from a poly(acrylic acid) derivative and β-cyclodextrin dimer

Polyurea‐urethane Temperature‐responsive Hydrogels for Sustained Delivery of Anti‐VEGF Therapeutics

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