PEG coated and doxorubicin loaded multimodal Gadolinium oxide nanoparticles for simultaneous drug delivery and imaging applications

Kumar, Shailja; Meena, Virendra Kumar; Hazari, Puja Panwar; Sharma, Rakesh Kumar

doi:10.1016/j.ijpharm.2017.05.027

Cited by 26 publications

(8 citation statements)

References 44 publications

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“…Then, the generated heat diffuses away from the surface of the hot AuNPs and leads to an increase in the temperature of the surrounding medium [ 20 – 24 ]. Plasmonic photothermal heating using AuNPs has been successfully used for various applications, including; diagnostic reagents [ 25 ], drug carriers [ 26 ], contrast agents [ 27 ], radiosensitizers [ 25 , 28 ] and specially photothermal therapy agents [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

LED control of gene expression in a nanobiosystem composed of metallic nanoparticles and a genetically modified E. coli strain

et al. 2021

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Background Within the last decade, genetic engineering and synthetic biology have revolutionized society´s ability to mass-produce complex biological products within genetically-modified microorganisms containing elegantly designed genetic circuitry. However, many challenges still exist in developing bioproduction processes involving genetically modified microorganisms with complex or multiple gene circuits. These challenges include the development of external gene expression regulation methods with the following characteristics: spatial–temporal control and scalability, while inducing minimal permanent or irreversible system-wide conditions. Different stimuli have been used to control gene expression and mitigate these challenges, and they can be characterized by the effect they produce in the culture media conditions. Invasive stimuli that cause permanent, irreversible changes (pH and chemical inducers), non-invasive stimuli that cause partially reversible changes (temperature), and non-invasive stimuli that cause reversible changes in the media conditions (ultrasound, magnetic fields, and light). Methods Opto-control of gene expression is a non-invasive external trigger that complies with most of the desired characteristics of an external control system. However, the disadvantage relies on the design of the biological photoreceptors and the necessity to design them to respond to a different wavelength for every bioprocess needed to be controlled or regulated in the microorganism. Therefore, this work proposes using biocompatible metallic nanoparticles as external controllers of gene expression, based on their ability to convert light into heat and the capacity of nanotechnology to easily design a wide array of nanostructures capable of absorbing light at different wavelengths and inducing plasmonic photothermal heating. Results Here, we designed a nanobiosystem that can be opto-thermally triggered using LED light. The nanobiosystem is composed of biocompatible gold nanoparticles and a genetically modified E. coli with a plasmid that allows mCherry fluorescent protein production at 37 °C in response to an RNA thermometer. Conclusions The LED-triggered photothermal protein production system here designed offers a new, cheaper, scalable switchable method, non-destructive for living organisms, and contribute toward the evolution of bioprocess production systems.

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Section: Introductionmentioning

confidence: 99%

LED control of gene expression in a nanobiosystem composed of metallic nanoparticles and a genetically modified E. coli strain

et al. 2021

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“…Dox fluorescence revealed high cellular uptake after incubation for 3 h. Gadolinium would be used as a contrasting agent for MR imaging. The cytotoxicity of the synthesized NPs was confirmed on A-549, PANC-1 and U-87 cancerous cell lines which represent lung, pancreatic, and brain cancer respectively [130].…”

Section: Theranostic Metal Nanoparticlesmentioning

confidence: 89%

Nano-engineered delivery systems for cancer imaging and therapy: Recent advances, future direction and patent evaluation

Nabil

Bhise

et al. 2019

Drug Discovery Today

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Cancer is the second-highest cause of death worldwide. Several therapeutic approaches, such as conventional chemotherapy, antibodies and small-molecule inhibitors and nanotherapeutics, have been employed in battling cancer. Among them, nanotheranostics is an example of successful personalized medicine bearing the dual role of early diagnosis and therapy to cancer patients. In this review, we focus on various types of theranostic polymer and metal nanoparticles for their roles in cancer therapy and imaging concerning their limitations and future applications, such as dendritic cell cancer vaccination, gene delivery, T cell activation and immune modulation. Some of the recorded patent applications and clinical trials are illustrated and the impact of the biological microenvironment on the biodistribution and accumulation of nanoparticles is also discussed.

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“…Apart from iron oxide nanoparticles several other metal oxide nanoparticles have been constructed and used for imaging, and drug delivery applications [165, 189–191]. However, their use is often limited due to the accumulation of metal in the body after drug administration causing toxicity.…”

Section: Nanomaterials As Drug Delivery Agentsmentioning

confidence: 99%

Current trends and challenges in cancer management and therapy using designer nanomaterials

Navya¹,

et al. 2019

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Nanotechnology has the potential to circumvent several drawbacks of conventional therapeutic formulations. In fact, significant strides have been made towards the application of engineered nanomaterials for the treatment of cancer with high specificity, sensitivity and efficacy. Tailor-made nanomaterials functionalized with specific ligands can target cancer cells in a predictable manner and deliver encapsulated payloads effectively. Moreover, nanomaterials can also be designed for increased drug loading, improved half-life in the body, controlled release, and selective distribution by modifying their composition, size, morphology, and surface chemistry. To date, polymeric nanomaterials, metallic nanoparticles, carbon-based materials, liposomes, and dendrimers have been developed as smart drug delivery systems for cancer treatment, demonstrating enhanced pharmacokinetic and pharmacodynamic profiles over conventional formulations due to their nanoscale size and unique physicochemical characteristics. The data present in the literature suggest that nanotechnology will provide next-generation platforms for cancer management and anticancer therapy. Therefore, in this critical review, we summarize a range of nanomaterials which are currently being employed for anticancer therapies and discuss the fundamental role of their physicochemical properties in cancer management. We further elaborate on the topical progress made to date toward nanomaterial engineering for cancer therapy, including current strategies for drug targeting and release for efficient cancer administration. We also discuss issues of nanotoxicity, which is an often-neglected feature of nanotechnology. Finally, we attempt to summarize the current challenges in nanotherapeutics and provide an outlook on the future of this important field.

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PEG coated and doxorubicin loaded multimodal Gadolinium oxide nanoparticles for simultaneous drug delivery and imaging applications

Cited by 26 publications

References 44 publications

LED control of gene expression in a nanobiosystem composed of metallic nanoparticles and a genetically modified E. coli strain

LED control of gene expression in a nanobiosystem composed of metallic nanoparticles and a genetically modified E. coli strain

Nano-engineered delivery systems for cancer imaging and therapy: Recent advances, future direction and patent evaluation

Current trends and challenges in cancer management and therapy using designer nanomaterials

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