PEG-based nanocomposite hydrogel: Thermoresponsive sol-gel transition controlled by PLGA-PEG-PLGA molecular weight and solute concentration

Miyazaki, Masaru; Maeda, Takeshi; Hirashima, K.; Kurokawa, Naruki; Nagahama, Koji; Hotta, Atsushi

doi:10.1016/j.polymer.2017.03.016

Cited by 56 publications

(39 citation statements)

References 41 publications

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“…Thus a pH and temperature sensitive hydrogel prepared from dextrin and poly(acrylic acid) has been used for sustained release of ornidazole and ciprofloxacin. 31 Some block copolymers show sol-gel transitions when the temperature is increased to 37 1C, 32,33 and these polymers have been used for dissolution of an anticancer drug with subsequent gelation upon injection.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable pH-responsive hydrogels for controlled dual-drug release

Qiu

Yang

et al. 2018

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Biodegradable pH-responsive hydrogels for controlled dual-drug release

Qiu

Yang

et al. 2018

J. Mater. Chem. B

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“…They also revealed that a single injection of DOX-loaded thermoresponsive nanocomposite hydrogel exhibited long-term sustained antitumor activity in vivo. In 2017, Miyazaki and Maeda et al reported on controlling the T gel and viscoelasticity of thermoresponsive nanocomposite hydrogels by PLGA-PEG-PLGA molecular weight and solute concentration (Figure 7c) [66]. We synthesized PLGA-PEG-PLGA with a high PEG-PLGA ratio of 0.80 and prepared the nanocomposite solution by mixing laponite aqueous suspension and PLGA-PEG-PLGA aqueous solution.…”

Section: Thermoresponsive Nanocomposite Hydrogels Composed Of Laponitmentioning

confidence: 99%

Structures and Applications of Thermoresponsive Hydrogels and Nanocomposite-Hydrogels Based on Copolymers with Poly (Ethylene Glycol) and Poly (Lactide-Co-Glycolide) Blocks

Maeda

2019

Bioengineering

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Thermoresponsive hydrogels showing biocompatibility and degradability have been under intense investigation for biomedical applications, especially hydrogels composed of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLGA) as first-line materials. Even though various aspects such as gelation behavior, degradation behavior, drug-release behavior, and composition effect have been studied for 20 years since the first report of these hydrogels, there are still many outputs on parameters affecting their gelation, structure, and application. In this review, the current trends of research on linear block copolymers composed of PEG and PLGA during the last 5 years (2014-2019) are summarized. In detail, this review stresses newly found parameters affecting thermoresponsive gelation, findings from structural analysis by simulation, small-angle neutron scattering (SANS), etc., progress in biomedical applications including drug delivery systems and regeneration medicine, and nanocomposites composed of block copolymers with PEG and PLGA and nanomaterials (laponite).

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“…Solid PMEA at physiological temperature, therefore, has been genuinely expected for further biomedical applications, [ 8,9 ] and various chemical and synthetic attempts to obtain solid PMEA have been made for the more stable and long‐lasting coating. The attempts ranged from polymer blending to copolymerization with other polymers possessing higher glass transition temperature.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Thermoplastic Poly(2‐methoxyethyl acrylate)‐Based Polyurethane by RAFT and Condensation Polymerization

Tazawa

Maeda

Nakayama

et al. 2020

Macromol. Rapid Commun.

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Thermoplastic solid poly(2‐methoxyethyl acrylate) (PMEA)‐based polyurethane (PU) is synthesized through the reversible addition−fragmentation chain transfer (RAFT) polymerization and the condensation polymerization, using hydroxyl‐terminated RAFT reagents and diisocyanate, respectively. Neat PMEA is a promising antithrombogenic liquid used in the medical fields. The thermoplastic property of the solid PMEA‐based PU due to hydrogen bonding is confirmed by the dynamic mechanical analysis (DMA) at temperature below 72 °C. The antithrombogenic property of PMEA‐based PU is also analyzed by the platelet adhesion test. The number of platelets on PMEA‐based PU is 17 cells per unit area, which is smaller than that on the fluorinated diamond‐like carbon (F‐DLC), a well‐known highly antithrombogenic material. It is concluded that a newly synthesized PMEA‐based PU exhibits thermoplastic characteristics with excellent antithrombogenicity.

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PEG-based nanocomposite hydrogel: Thermoresponsive sol-gel transition controlled by PLGA-PEG-PLGA molecular weight and solute concentration

Cited by 56 publications

References 41 publications

Biodegradable pH-responsive hydrogels for controlled dual-drug release

Biodegradable pH-responsive hydrogels for controlled dual-drug release

Structures and Applications of Thermoresponsive Hydrogels and Nanocomposite-Hydrogels Based on Copolymers with Poly (Ethylene Glycol) and Poly (Lactide-Co-Glycolide) Blocks

Synthesis of Thermoplastic Poly(2‐methoxyethyl acrylate)‐Based Polyurethane by RAFT and Condensation Polymerization

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