PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma

Zheng, Wen; Ren, Hanyun; Ke, Xiaoyan; Xue, Mei; Zhang, Yongqing; Xie, Yun; Lin, Ningjing; Tu, Meifeng; Liu, Weiping; Ping, Lingyan; Ying, Zhitao; Zhang, Chen; Deng, Lijuan; Wang, Xiaopei; Song, Yuqin; Zhu, Jun

doi:10.21147/j.issn.1000-9604.2017.01.08

Cited by 10 publications

(8 citation statements)

References 25 publications

(37 reference statements)

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“…Gastric cancer (GC) is one of the leading causes of cancer related mortality globally (1). China has a high prevalence of GC (2), where the incidence ranked second and the mortality ranked third for all types of cancers (3). Although comprehensive studies of GC have been performed, the mechanisms of its development, progression, metastasis and invasion remain largely unclear, which greatly limits GC therapeutic treatments.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1

et al. 2019

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Gastric cancer (GC) is a global health problem with poor clinical outcomes. The mechanism of its development and progression remains largely unclear. The present study investigated the role of microRNA-9 (miR-9-5p) in the development and progression of GC. Overexpression of miR-9-5p led to reduced expression of neuropilin-1 (NRP-1) in GC cells. Dual-luciferase reporter assay results indicated that miR-9-5p directly targeted NRP-1. Furthermore, overexpression of miR-9-5p in GC cells increased the expression of mesenchymal markers, N-cadherin and vimentin, and decreased the expression of epithelial markers, E-cadherin and β-catenin. Overexpression of miR-9-5p inhibited GC cell proliferation, migration and invasion, and increased the sensitivity of GC cells to the anti-cancer drug cisplatin. By contrast, the opposite effects were observed in GC cells following downregulation of miR-9-5p. Taken together, the present findings suggested that miR-9-5p suppressed NRP-1 expression and inhibited GC cell proliferation and invasion. In addition, miR-9-5p overexpression attenuated GC cell resistance to anti-cancer drugs, which highlighted the potential of miR-9-5p as a target for the treatment of GC.

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Section: Introductionmentioning

confidence: 99%

MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1

et al. 2019

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“…The latest report showed that lung cancer caused approximately 597,000 deaths in China in 2013 (3). Of lung cancer cases, approximately 95% are non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) (48), which together represent the most common cause of cancer-related death globally (49,50).…”

Section: Exosomal Mirnas and Proteins In Lung Cancermentioning

confidence: 99%

“…In China, the numbers of newly diagnosed cases and deaths were approximately 3.0 million and 1.9 million, respectively, in 2010 (2). According to 2013 data, lung cancer, liver cancer and gastric cancer are the top three leading causes of mortality in males in China, whereas lung cancer, gastric cancer and liver cancer are the top three leading causes of mortality in females (3) (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review)

Liu

et al. 2018

Oncol Lett

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Cancer is the second leading cause of mortality worldwide. More importantly, the mortality rates for cancer are increasing. In China, lung cancer, liver cancer and gastric cancer are the top three leading causes of mortality in males, whereas lung cancer, gastric cancer and liver cancer are ranked the top three causes of mortality in females. Exosomes are extracellular vesicles that are produced and released by many different cells; these vesicles have a size range between 30 and 100 nm in diameter, and contain a lipid bilayer. Exosomes exist in various bodily fluids, contain plentiful amounts of nucleic acids and proteins, and shuttle these materials between cells to mediate the development of cancers. The present review summarizes the composition of exosomes and methods for their isolation and then intensively highlights the latest findings on the contributions of exosomal microRNAs (miRNAs) and proteins to lung cancer, liver cancer and gastric cancer. Taken together, exosomal miRNAs and proteins may be used as noninvasive, novel biomarkers for cancer diagnosis, prognosis or precision treatment owing to their ability to promote tumor progression and metastasis, and their ability to regulate the immune response and tumor cell sensitivity to chemotherapy drugs.

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“…Asparaginase is also used as coadjuvant in the treatment of haematological malignancies such as acute lymphoblastic leukemia (ALL), therefore it is included in the list of essential medicines of the World Health Organization . Even though it is primarily used to treat ALL, clinical trials have been conducted to evaluate its effects on tumours of the lymphatic and hematopoietic system, such as lymphoblastic lymphoma and extranodal lymphoma of NK/ T cells …”

Section: Introductionmentioning

confidence: 99%

Asparaginase induces selective dose‐ and time‐dependent cytotoxicity, apoptosis, and reduction of NFκB expression in oral cancer cells

Borges

Elias

Araujo

et al. 2020

Clin Exp Pharma Physio

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Asparaginase is fundamental to the treatment of haematological malignancies. However, little has been studied on the effects that asparaginase could exert on solid tumours. Thus, this study aimed to evaluate the effects of asparaginase on an oral carcinoma cell line. The cytotoxicity of asparaginase in SCC‐9 (tongue squamous cell carcinoma) and HaCaT (human keratinocyte) cell lines was evaluated with MTT cell viability assay. The cells were treated with asparaginase at 0.04, 0.16, 0.63, 1.0, 1.5, 2.5, and 5.0 IU/mL. Dose‐response curves and IC50 values were obtained and the Tumour Selectivity Index (TSI) was calculated. The effect of asparaginase on procaspase‐3 and nuclear factor κB (NFκB) expression was evaluated with western blot because it was reported that the overexpression of NFκB has been shown to contribute to tumour cell survival, proliferation, and migration. Caspase 3/7 staining was performed to identify cell death using flow cytometry. Effective asparaginase concentrations were lower for SCC‐9 cells when compared to HaCaT cells. The cytotoxicity results at 48 and 72 hours were significantly different for SCC‐9 cells. The TSI indicated that asparaginase was selective for the tumour cells. A decrease in procaspase‐3 and NFκB protein levels was observed in SCC‐9 cells. Furthermore, asparaginase resulted in significant apoptosis after 48 and 72 hours. Based on these results, asparaginase was cytotoxic in a dose‐ and time‐dependent manner, induces apoptosis, and reduces NFκB expression in oral cancer cells. These results encourage further studies on the effectiveness of this enzyme as a treatment for solid tumours, especially head and neck cancer.

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PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma

Cited by 10 publications

References 25 publications

MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1

MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1

Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review)

Asparaginase induces selective dose‐ and time‐dependent cytotoxicity, apoptosis, and reduction of NFκB expression in oral cancer cells

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