PEG 400/Paraffin oil non‐aqueous emulsions stabilized by PBut‐Block‐P2VP block copolymers

Abstract

For the preparation of PEG 400 in paraffin oil non-aqueous biocompatible emulsions, the stabilization efficiency was compared for two well-defined poly(butadiene)-block-poly(2-vinylpyridine) (PBut-block-P2VP) block copolymers, with similar molecular weights but different compositions. The PBut 128 -block-P2VP 50 and PBut 189 -block-P2VP 37 samples, designated as copolymer A and B, respectively, are self-organized in paraffin oil as micelles with a P2VP core and a PBut corona. The PEG 400/paraffin oil emulsion characteristics were determined as a function of the copolymers concentrations and phase ratios. Higher static and shear stabilities were obtained for emulsions stabilized by copolymer B than for those obtained in the presence of copolymer A. A further difference concerns the droplet size, relative viscosity, and loss modulus values obtained at a given dispersed phase volume fraction. At constant copolymer concentrations, it appeared that copolymer B, with a longer PBut sequence, is a more efficient emulsifier and stabilizer than copolymer A.

Particles adsorbed at various non-aqueous liquid-liquid interfaces

“…The bulk 3D-rheology in which an emulsion prepared with the two fluids and the particles is subjected to periodic shear or squeeze deformations obtain the 3D viscosity and elasticity of the emulsion as a function of the shear or squeeze rate and time. This bulk characterization provides important information concerning the flow behaviour and the stability of the emulsions, useful for practical applications [20]. Moreover, this can be performed at the same time as the real structure of the emulsion is obtained by confocal microscopy [25].…”

“…When the water phase is replaced by a polar solvent like propylene glycol [11], glycerol [12,13], formamide [14,15,13,16,17] or methanol [18], the solvent-oil interface is expected to retain the essential physics as that with the water phase [9]. On the other hand, the cases of liquid polymer-oil [19,20,21,22,23] and immiscible liquid polymer blends [24] [ 25,26,27,28,29,30,31,32,33,34] [35,36,37,38,39,40,41,42] [43,44] are quite different and reported more frequently in the literature due to their important industrial applications. Nevertheless, we want to stress also the less studied case of true oil-oil interfaces.…”

Self-Assembly of Block and Graft Copolymers in Organic Solvents: An Overview of Recent Advances

“…Our research group studied the micellization of P2VP- b -PEO diblock copolymers in several biocompatible solvents, such as PEG400 (δ = 21.3 MPa 1/2 ), paraffin oil (δ = 15.3 MPa 1/2 ), and Miglyol 812 (δ = 17.3 MPa 1/2 ) [ 73 , 74 , 75 ]. Spherical micelles, having a P2VP core and a R h in the range of 23 to 25 nm were obtained by the self-assembly of P2VP 37 - b -PB 189 copolymer sample in paraffin oil and Miglyol 812, which is a glycerine ester.…”

Antitumoral Drug-Loaded Biocompatible Polymeric Nanoparticles Obtained by Non-Aqueous Emulsion Polymerization

“…In this type of emulsion, usually designated as oil-in-oil (O/O) emulsion, the monomer droplets are dispersed in a non-miscible oil and the stabilization can be achieved by using tailor-made copolymers. It has been shown that copolymers can provide longer stability for O/O emulsions with respect to the conventional surfactants because they have a much slower desorption kinetics at the interface of the droplets [21][22][23][24]. Moreover, it is well known that PNVP, which is FDA approved, is a hydrophilic polymer and has a good efficiency to control the release rate of poorly water-soluble drugs [25].…”