Peer-to-peer Monte Carlo simulation of photon migration in topical applications of biomedical optics

Doronin, Alexander; Meglinski, Igor

doi:10.1117/1.jbo.17.9.090504

Cited by 58 publications

(44 citation statements)

References 23 publications

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“…Using a dual quadcore workstation (2.1 GHz AMD Opteron Processor 2352), a simulation of Rayleigh scattering for 10 8 photons can be run in less than 1.5 h. Future developments to our code can implement GPU acceleration and peer-to-peer networking to further improve the speed of our simulations. 49 Finally, we provided demonstrations of the results from simulations for purely scattering samples and samples containing scattering and linear birefringence. These simulation results demonstrate a strong dependence of the shape of the coherent spatial reflectance profile on polarization, illumination wavelength, scattering form factor, and degree of linear birefringence.…”

Section: Discussionmentioning

confidence: 99%

Open source software for electric field Monte Carlo simulation of coherent backscattering in biological media containing birefringence

Radosevich¹,

Rogers²,

Capoglu³

et al. 2012

J. Biomed. Opt

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Abstract.We present an open source electric field tracking Monte Carlo program to model backscattering in biological media containing birefringence, with computation of the coherent backscattering phenomenon as an example. These simulations enable the modeling of tissue scattering as a statistically homogeneous continuous random media under the Whittle-Matérn model, which includes the Henyey-Greenstein phase function as a special case, or as a composition of discrete spherical scatterers under Mie theory. The calculation of the amplitude scattering matrix for the above two cases as well as the implementation of birefringence using the Jones N-matrix formalism is presented. For ease of operator use and data processing, our simulation incorporates a graphical user interface written in MATLAB to interact with the underlying C code. Additionally, an increase in computational speed is achieved through implementation of message passing interface and the semi-analytical approach. Finally, we provide demonstrations of the results of our simulation for purely scattering media and scattering media containing linear birefringence.

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Section: Discussionmentioning

confidence: 99%

Open source software for electric field Monte Carlo simulation of coherent backscattering in biological media containing birefringence

Radosevich¹,

Rogers²,

Capoglu³

et al. 2012

J. Biomed. Opt

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“…20,21 Thus, the developed O3MC code utilizes the Compute Unified Device Architecture (CUDA) parallel computing platform (recently introduced by NVIDIA Corporation) that allows simultaneous execution of thousands of lightweight parallel threads. 22 Each thread is responsible for the simulating the propagation of one photon trajectory in the scattering medium.…”

Section: Gpu Accelerated Monte Carlo Modeling Of Photon Migration In mentioning

confidence: 99%

“…We adapted the Jones-based formalism to handle linear or circular polarization of coherent light traveling through a random turbid medium. 33 The developed MC approach is a part of the O3MC online tool 20,21 and has been extended for modelling propagation and scattering of vector light beams in complex tissue-like scattering media.…”

Section: Modeling Of Coherent Vector Light Beam Propagation In Scattementioning

confidence: 99%

“…The developed model utilizes Jones formalism specially adapted for the online object oriented MC (O3MC) approach developed earlier. 20,21 The model takes into account the wave properties of light, including temporal coherence, polarization, interference and reflection/refraction at the medium boundary, as well as the helicity flip of the backscattered circularly polarized light.…”

Section: Introductionmentioning

confidence: 99%

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Propagation and scattering of vector light beam in turbid scattering medium

et al. 2014

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Due to its high sensitivity to subtle alterations in medium morphology the vector light beams have recently gained much attention in the area of photonics. This leads to development of a new non-invasive optical technique for tissue diagnostics. Conceptual design of the particular experimental systems requires careful selection of various technical parameters, including beam structure, polarization, coherence, wavelength of incident optical radiation, as well as an estimation of how the spatial and temporal structural alterations in biological tissues can be distinguished by variations of these parameters. Therefore, an accurate realistic description of vector light beams propagation within tissue-like media is required. To simulate and mimic the propagation of vector light beams within the turbid scattering media the stochastic Monte Carlo (MC) technique has been used. In current report we present the developed MC model and the results of simulation of different vector light beams propagation in turbid tissue-like scattering media. The developed MC model takes into account the coherent properties of light, the influence of reflection and refraction at the medium boundary, helicity flip of vortexes and their mutual interference. Finally, similar to the concept of higher order Poincaré sphere (HOPS), to link the spatial distribution of the intensity of the backscattered vector light beam and its state of polarization on the medium surface we introduced the color-coded HOPS.

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“…To further quantify the efficacy of the proposed SP N method for the photon migration modeling in scattering medium, the following standard deviation of the quantity of interest is defined as a measure [9]:…”

mentioning

confidence: 99%

Analytical solutions to the simplified spherical harmonics equations using eigen decompositions

Zhang

et al. 2013

Opt. Lett.

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We develop a modified method to simplify the analytical solutions to the simplified spherical harmonics equations (SP(N)). The scheme decouples the SP(N) partial differential equations into independent equations using eigen decompositions and calculates the Green's function of the photon migrations based on the eigenvectors and eigenvalues. In contrast to the established solutions that are based on the original coupled equations, the proposed derivation is theoretically concise and universally extendable to other regular geometries. We validate the proposed method in comparison with Monte-Carlo simulations for an infinite scattering medium and a circular geometry as an example of the boundary value problems.

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Peer-to-peer Monte Carlo simulation of photon migration in topical applications of biomedical optics

Cited by 58 publications

References 23 publications

Open source software for electric field Monte Carlo simulation of coherent backscattering in biological media containing birefringence

Open source software for electric field Monte Carlo simulation of coherent backscattering in biological media containing birefringence

Propagation and scattering of vector light beam in turbid scattering medium

Analytical solutions to the simplified spherical harmonics equations using eigen decompositions

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