Peer’s Presence Reverses Escalated Cocaine Intake in Rats

Vielle, Cassandre; Tiran-Cappello, Alix; Vignal, Lucie; Maurice, Nicolas; Degoulet, Mickael; Brocard, Cécile; Pelletier, Florence; Pelloux, Yann; Baunez, Christelle

doi:10.1101/2023.02.07.527550

Cited by 2 publications

(1 citation statement)

References 59 publications

(86 reference statements)

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“…The laser power at fiber tip was set, using a power meter (PM20A, Thorlabs), at 10mW for STN HF-stimulation and 5kW for its inhibition. The effect of these light delivery parameters on STN neurons firing pattern were previously tested in vitro and in vivo (Vielle et al, 2023). Nevertheless, we controlled here the effects of STN photo-inhibition and HF photo-stimulation, via extracellular recordings of STN activity in anesthetized animals (see above).…”

Section: Optogenetic Manipulationmentioning

confidence: 99%

The Subthalamic Nucleus Is Involved in Social Recognition Memory in Rats

Vielle

Maurice

Pelletier

et al. 2023

Preprint

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Human social behavior is a complex construct requiring a wide range of cognitive abilities and is critically impaired in numerous neuropsychiatric diseases. Living in complex social groups, rodents offer suitable models to elucidate neural processing of social cognition. Recently, a potential involvement of the subthalamic nucleus (STN) in rats social behavior has been pointed out. For example, we showed that STN lesions abolish the modulatory effect of the familiarity on the rewarding value of social stimuli, questioning the involvement of STN in peer recognition. In this study, we thus assess the effects of STN lesions and optogenetic manipulations on peer and object recognition. STN optogenetic inhibition, like lesions, impair social recognition memory, while STN optogenetic high-frequency (HF) stimulation leads to a specific alteration of social encoding memory. None of these manipulations seem to interfere with social investigation, objects recognition memory, nor social novelty preference. Finally, STN optogenetic inhibition, but neither HF-stimulation, nor lesions, leads to an alteration of the cage-mate recognition memory. Overall, these results show that physiological activity of STN is necessary for rats to show a proper social recognition memory performance and question the possible detrimental effects of STN deep brain stimulation on these processes in human patients

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Section: Optogenetic Manipulationmentioning

confidence: 99%

The Subthalamic Nucleus Is Involved in Social Recognition Memory in Rats

Vielle

Maurice

Pelletier

et al. 2023

Preprint

Self Cite

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Subthalamic High-Frequency Deep Brain Stimulation Reduces Addiction-Like Alcohol Use and Suppresses the Overconsumption Induced by the Peer’s Presence

Vignal,

Vielle,

Williams

et al. 2023

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RationalThe immediate social context significantly influences alcohol consumption in humans. Recent studies have revealed that peer presence could modulate drugs use in rats. The most efficient condition to reduce cocaine intake is the presence of a stranger peer, naive to drugs. Deep brain stimulation (DBS) of the Subthalamic Nucleus (STN), which was shown to have beneficial effects on addiction to cocaine or alcohol, also modulate the protective influence of peer’s presence on cocaine use.ObjectivesThis study aimed to: 1) explore how the presence of an alcohol-naive stranger peer affects recreational and escalated alcohol intake, and 2) assess the involvement of STN on alcohol use and in the modulation induced by the presence of an alcohol-naïve stranger peer.MethodsRats with STN DBS and control animals self-administered 10% (v/v) ethanol in presence, or absence, of an alcohol-naive stranger peer, before and after escalation of ethanol intake (observed after intermittent alcohol (20% (v/v) ethanol) access).ResultsNeither STN DBS nor the presence of an alcohol-naive stranger peer modulated significantly recreational alcohol intake. After the escalation procedure, STN DBS gradually reduced ethanol consumption. The presence of an alcohol-naive stranger peer increased consumption only in low drinkers, which effect was suppressed by STN DBS.ConclusionsThese results highlight the influence of a peer’s presence on escalated alcohol intake, and confirm the role of STN in addiction-like alcohol intake and in the social influence on drug consumption.

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Peer’s Presence Reverses Escalated Cocaine Intake in Rats

Cited by 2 publications

References 59 publications

The Subthalamic Nucleus Is Involved in Social Recognition Memory in Rats

The Subthalamic Nucleus Is Involved in Social Recognition Memory in Rats

Subthalamic High-Frequency Deep Brain Stimulation Reduces Addiction-Like Alcohol Use and Suppresses the Overconsumption Induced by the Peer’s Presence

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