Peer Reviewed: NMR Spectroscopy: Past and Present

Fluorine-19 or phosphorus-31 NMR spectroscopy: A suitable analytical technique for quantitative in vitro metabolic studies of fluorinated or phosphorylated drugs

“…Today, about 60 years after the observation of proton nuclear magnetic resonance ( 1 H NMR) in liquid water and paraffin wax by research groups led by Bloch at Stanford University and Purcell at Harvard University, NMR has become a major tool for determining molecular structures and has found many applications not only in chemistry but also in other fields such as materials science, biology and medicine [1]. Indeed the last 30 years have seen considerable development of biological NMR since it is the only physical method used routinely for the direct study at the molecular level of biological samples, from biofluids, cell or tissue extracts, excised tissues, packed intact cells (in vitro studies) to isolated living cells or isolated perfused organs (ex vivo studies), and finally animal models and human subjects (in vivo studies).…”

Structural and Kinetic Considerations for the Application of the Traceless Staudinger Ligation to Future 18F Radiolabeling Using XRD and 19F NMR

“…In the past, 19 F NMR has been used as an excellent tool for kinetic studies on chemical reactions [38,39].…”

Schrödinger Cat State Spectroscopy—A New Frontier for Analytical Chemistry

“…6 Similar concepts are responsible for NMR cross-peaks. 7 These same ideas form the basis for fluorescence and Raman spectroscopy but in a very strange way. Fluorescence and Raman are based on populations that result from the collapse of a cat state created by an electromagnetic field.…”

“…The coupling requirement is a powerful approach for removing spectral congestion . Similar concepts are responsible for NMR cross-peaks …”