Peer Review #1 of "Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting ATP1a1 (v0.1)"
Abstract:Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy. By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of interest for further investigation. However, the low efficiency of targeting in iPSCs has hampered the application of genome editing. In this study we used a CRISPR-Cas9 system that introduces a specific point substitution into the sequence of the Na + /K +-ATPase subunit ATP… Show more
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