Peer Review #1 of "Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors (v0.1)"
Abstract:Background: administration of anandamide (AEA) or 2-arachidonoylglycerol (2AG) induces CB1 coupling and activation of TRKB receptors, regulating the neuronal migration and maturation in the developing cortex. However, at higher concentrations AEA also engages vanilloid receptor-TRPV1, usually with opposed consequences on behavior. Methods and Results: Using primary cell cultures from the cortex of rat embryos (E18) we determined the effects of AEA on phosphorylated TRKB (pTRK). We observed that AEA (at 100 and… Show more
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