Peer problems are associated with elevated serum leptin levels in children

Kohlboeck, Gabriele; Romanos, Marcel; Tiesler, Carla M. T.; Koletzko, Sibylle; Kratzsch, Jürgen; Thiery, Joachim; Bauer, Carl‐Peter; Berg, Andrea von; Berdel, Dietrich; Hoffmann, Barbara; Schaaf, Beate; Lehmann, Irina; Herbarth, Olf; Heinrich, Joachim

doi:10.1017/s003329171300069x

Cited by 12 publications

(12 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, this is the first prospective epidemiological study investigated associations between fetal adipokine levels and child behavioral problems. Child behavioral problems in association with obesity, overweight and high BMI have been reported through cross-sectional studies [ 24 , 25 , 26 ]. Similarly, several previous studies investigated child behavioral problems and cognitive and motor development in association with leptin levels in cross-sectional studies [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Minatoya

Itoh

Araki

et al. 2018

IJERPH

View full text Add to dashboard Cite

Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk between adipokines, including inflammatory cytokines and metabolic hormones secreted from adipose tissue and the central nervous system needs to be further investigated to elucidate the mechanism. Thus, the aim of this study was to investigate the association between fetal adipokine levels and child behavioral problems at preschool age. Cord blood adiponectin, leptin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) levels were measured and child behavioral problems were assessed using the Strengths and Difficulties Questionnaire at preschool age. Logistic regression models adjusted by related maternal factors were performed to examine the association between cord blood adipokines and child behavioral problems. Three hundred and sixty-one children were included in the final analysis. A significant association between decreased hyperactivity/inattention and increased leptin was found (OR = 0.22, 95% CI: 0.06–0.89). Cord blood adiponectin, TNF-α and IL-6 levels were not associated with child behavioral problems. Our findings suggested that cord blood adipokines, particularly, leptin level, may be a predictor of hyperactivity/inattention problems at preschool age.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Minatoya

Itoh

Araki

et al. 2018

IJERPH

View full text Add to dashboard Cite

show abstract

“…As leptin is a major regulator of bone mass [10], a leptin deficiency may alter the BMD [34]. Leptin is also increased by emotional stress, which is also one of the many environmental factors potentially leading to obesity [35,36].…”

Section: Adiposity-bone Metabolism Cross-talkmentioning

confidence: 99%

Bone-adiposity cross-talk: implications for pediatric obesity

et al. 2015

View full text Add to dashboard Cite

The rising prevalence of overweight and obesity among pediatric populations has become a major global concern. The objective of this review is to demonstrate potential interactions between the products released by fat tissue and the hormonal production of bone tissue in obese children and adolescents. Advancing the understanding of the complex interactions between adipocyte and osteocyte activities may contribute to the mechanistic understanding of the body's responses to weight loss during adolescence. This knowledge could also reveal any side effects encountered with these interventions. Currently, the concept of bone-adiposity crosstalk has not been fully elucidated, and the mechanisms remain controversial. Understanding the local interactions between the released products by fat tissue and hormones produced in bone tissue requires further investigations.

show abstract

“…In our study, significances were only found in girls: leptin levels were higher with higher daily cortisol output. Indeed, sex‐differences have previously been mentioned in the associations with significant results in women only. Moreover, sex differences have been revealed in leptin levels, due to testosterone‐induced leptin downregulation but also in prepubertal child populations .…”

Section: Discussionmentioning

confidence: 96%

“…In an increasing amount of studies, psychosocial stress has been associated with higher leptin levels in adults and in children only for peer/emotional problems . Nevertheless, depression has also been associated with lower leptin levels and some studies found no significant associations with adult depression or child trauma .…”

Section: Discussionmentioning

confidence: 99%

“…less sensitivity) with increased comfort food intake as a result. 3,9 In several studies, psychosocial stress has been associated with higher leptin levels e.g., for self-reported stress, 10 depression, 11,12 trauma, 13 and peer/emotional problems, 14 as was the case for chronically-elevated stress hormone cortisol levels. 15 Nevertheless, sex-differences 11,14,16,17 and inconsistent results 18 or non-significant studies [19][20][21] have also been published.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Children's psychosocial stress and emotional eating: A role for leptin?

Michels

Sioen

Ruige

et al. 2016

Intl J Eating Disorders

View full text Add to dashboard Cite

Stress (represented by emotional problems and high daily cortisol) seems to lead to hyperleptinemia in girls; and the combination of high stress and hyperleptinemia might make girls more vulnerable to stress-induced eating. No functional data on leptin sensitivity were present, but results might suggest that stress induces lower sensitivity to the anorexigenic leptin activity. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2017; 50:471-480).

show abstract

Peer problems are associated with elevated serum leptin levels in children

Abstract: Children with peer problems have higher stress and eat more, acquire a higher body fat mass and thus, through increased leptin resistance, exhibit higher leptin levels.

Cited by 12 publications

References 65 publications

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Bone-adiposity cross-talk: implications for pediatric obesity

Children's psychosocial stress and emotional eating: A role for leptin?

Contact Info

Product

Resources

About