Peer presence and familiarity as key factors to reduce cocaine intake in both rats and humans: an effect mediated by the subthalamic nucleus

Giorla, Elodie; Nordmann, Sandra; Vielle, Cassandre; Pelloux, Yann; Roux, Perrine; Protopopescu, Camélia; Manrique, Christine; Davranche, Karen; Montanari, Christian; Giorgi, Lisa; Vilotitch, Antoine; Huguet, Pascal; Carrieri, Patrizia; Baunez, Christelle

doi:10.1007/s00213-021-06033-0

Cited by 10 publications

(29 citation statements)

References 75 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By contrast to stranger, familiar 50-kHz USV playback did not affect cocaine consumption, suggesting that the rewarding value of familiar 50-kHz USV playback is not strong enough to counterbalance the reinforcing effect of cocaine. The lower impact of familiar USV playback (compared with unfamiliar) on cocaine self-administration is also in line with the lower influence of the presence of the cagemate [8]. One could hypothesize that the poor rewarding properties of familiar presence and USV playback and their consequences on drug consumption cannot be translated to humans because rats do not choose their cagemate, contrary to human beings.…”

Section: Discussionmentioning

confidence: 66%

“…R. Soc. B 288: 20212260 when alone [8]. Also, rats choose social interaction over the drug, confirming the beneficial effect of proximal social stimuli to reduce drug intake [50].…”

Section: Discussionmentioning

confidence: 76%

“…This difference could be critical for the rewarding value of familiar stimuli. However, in Giorla et al [8], human stimulant users also reported to take less drug in the presence of a stranger over a familiar peer. Taken altogether, our results suggest that positive communication and familiarity constitute key factors in the influence of social contact on cocaine consumption.…”

Section: Discussionmentioning

confidence: 93%

“…For instance, studies on drug consumption showed that the presence of a peer modulates drug intake [6], in a substance-specific way [7]. In both rats and humans, the presence of a peer decreases cocaine intake [8]. This protective effect of the peer's presence over drug consumption would result from its role as an alternative reinforcer, overcoming the rewarding value of drugs [9].…”

Section: Introductionmentioning

confidence: 99%

“…This protective effect of the peer's presence over drug consumption would result from its role as an alternative reinforcer, overcoming the rewarding value of drugs [9]. Interestingly, in both humans and rats, the relationship between the subject and the observer is important since the presence of a stranger peer decreases cocaine consumption more than the presence of a familiar one [8]. However, some questions remain to be addressed regarding the socio-affective modulation of behaviour, such as the sensory modalities involved and their neurobiological basis [10].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Evidence for a vocal signature in the rat and its reinforcing effects: a key role for the subthalamic nucleus

et al. 2021

View full text Add to dashboard Cite

Although rodents have a well-structured vocal form of communication, like humans and non-human primates, there is, to date, no evidence for a vocal signature in the well-known 50- and 22-kHz ultrasonic vocalizations (USVs) emitted by rats. Here, we show that rats can recognize the identity of the USV emitter since they choose to preferentially self-administer playback of 50-kHz USVs emitted by a stranger rat over those of their cagemate. In a second experiment, we show that only stranger, but not familiar, 50-kHz USVs reduce cocaine self-administration. Finally, to study the neurobiological substrate of these processes, we have shown that subthalamic nucleus (STN)-lesioned rats did not lever press much for any USV playback, whatever their emotional valence, nor did they seem able to differentiate familiar from stranger peer. Advocating for the existence of a vocal signature in rats, these results highlight the importance of ultrasonic communication in the socio-affective influence of behaviour, such as the influence of proximal social factors on drug consumption and confirm the role of the STN on this influence.

show abstract

Section: Discussionmentioning

confidence: 66%

“…R. Soc. B 288: 20212260 when alone [8]. Also, rats choose social interaction over the drug, confirming the beneficial effect of proximal social stimuli to reduce drug intake [50].…”

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evidence for a vocal signature in the rat and its reinforcing effects: a key role for the subthalamic nucleus

et al. 2021

View full text Add to dashboard Cite

show abstract

Animals Models Used to Study Alcohol Use Disorder

Lguensat,

Coppola,

Augier

2023

Alcohol and Alcohol-Related Diseases

View full text Add to dashboard Cite

Subthalamic high-frequency deep brain stimulation reduces addiction-like alcohol use and the possible negative influence of a peer presence

Vignal,

Vielle,

Williams

et al. 2024

Psychopharmacology

View full text Add to dashboard Cite

Rationale The immediate social context significantly influences alcohol consumption in humans. Recent studies have revealed that peer presence could modulate drugs use in rats. The most efficient condition to reduce cocaine intake is the presence of a stranger peer, naive to drugs. Deep brain stimulation (DBS) of the Subthalamic Nucleus (STN), which was shown to have beneficial effects on addiction to cocaine or alcohol, also modulates the protective influence of peer’s presence on cocaine use. Objectives This study aimed to: 1) explore how the presence of an alcohol-naive stranger peer affects recreational and escalated alcohol intake, and 2) assess the involvement of STN on alcohol use and in the modulation induced by the presence of an alcohol-naïve stranger peer. Methods Rats with STN DBS and control animals self-administered 10% (v/v) ethanol in presence, or absence, of an alcohol-naive stranger peer, before and after escalation of ethanol intake (observed after intermittent alcohol (20% (v/v) ethanol) access). Results Neither STN DBS nor the presence of an alcohol-naive stranger peer modulated significantly recreational alcohol intake. After the escalation procedure, STN DBS reduced ethanol consumption. The presence of an alcohol-naive stranger peer increased consumption only in low drinkers, which effect was suppressed by STN DBS. Conclusions These results highlight the influence of a peer’s presence on escalated alcohol intake, and confirm the role of STN in addiction-like alcohol intake and in the social influence on drug consumption.

show abstract

Peer presence and familiarity as key factors to reduce cocaine intake in both rats and humans: an effect mediated by the subthalamic nucleus

Cited by 10 publications

References 75 publications

Evidence for a vocal signature in the rat and its reinforcing effects: a key role for the subthalamic nucleus

Evidence for a vocal signature in the rat and its reinforcing effects: a key role for the subthalamic nucleus

Animals Models Used to Study Alcohol Use Disorder

Subthalamic high-frequency deep brain stimulation reduces addiction-like alcohol use and the possible negative influence of a peer presence

Contact Info

Product

Resources

About