PEEP Setting in ARDS

Rezoagli, Emanuele; Bellani, Giacomo

doi:10.1007/978-3-030-93401-9_17

Cited by 1 publication

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PEEP ensures that the pressure in the alveoli is higher than atmospheric pressure, and this creates a positive baseline pressure ( 3 ). PEEP can be further defined as extrinsic or intrinsic.…”

Section: Peep Definition: What Is the Benefit Of Its Use?mentioning

confidence: 99%

“…When PEEP is applied, the end expiratory lung volume (EELV) increases, which is predominately due to the recruitment of collapsed alveoli ( 6 ). An increased EELV leads to decreased lung strain and improved compliance, ultimately contributing to a decrease in DP ( 3 ).…”

Section: Peep Definition: What Is the Benefit Of Its Use?mentioning

confidence: 99%

“…Through these mechanisms, PEEP improves arterial oxygenation and may reduce the risk of ventilator-induced lung injury (VILI) by reducing atelectrauma resulting from the cyclic opening and closing of alveoli, preventing alveolar flooding, and reducing lung heterogeneity ( 3 ). Alveolar recruitment also reduces lung strain and improves lung compliance in both humans and dogs ( 6 , 7 ).…”

Section: Peep Definition: What Is the Benefit Of Its Use?mentioning

confidence: 99%

“…As previously mentioned, EELV increases when PEEP is applied, predominately due to the recruitment of collapsed alveoli. However, in low compliance lung regions or in alveoli that are already recruited, the increased EELV may also contribute to alveolar overdistention and a decrease in dynamic strain ( 3 ). Overdistention may lead to alveolar inflammation, injury, and increased lung stress.…”

Section: Negative Effects From Peepmentioning

confidence: 99%

“…Overdistention may lead to alveolar inflammation, injury, and increased lung stress. In addition, if alveolar pressure is greater than pulmonary capillary pressure, capillaries may be occluded and lead to increased alveolar dead space ( 3 ).…”

Section: Negative Effects From Peepmentioning

confidence: 99%

See 4 more Smart Citations

Setting the optimal positive end-expiratory pressure: a narrative review

Zersen

2023

Front. Vet. Sci.

View full text Add to dashboard Cite

The primary goals of positive end-expiratory pressure (PEEP) are to restore functional residual capacity through recruitment and prevention of alveolar collapse. Through these mechanisms, PEEP improves arterial oxygenation and may reduce the risk of ventilator-induced lung injury (VILI). Because of the many potential negative effects associated with the use of PEEP, much research has concentrated on determining the optimal PEEP setting. Arterial oxygenation targets and pressure-volume loops have been utilized to set the optimal PEEP for decades. Several other techniques have been suggested, including the use of PEEP tables, compliance, driving pressure (DP), stress index (SI), transpulmonary pressures, imaging, and electrical impedance tomography. Each of these techniques has its own benefits and limitations and there is currently not one technique that is recommended above all others.

show abstract

Section: Peep Definition: What Is the Benefit Of Its Use?mentioning

confidence: 99%

Section: Peep Definition: What Is the Benefit Of Its Use?mentioning

confidence: 99%