Peeling with 70% glicolic acid followed by 5% 5‐fluorouracil as well as 5% 5‐fluorouracil cream are effective methods for the treatment of actinic keratoses on upper limbs: A randomized clinical trial

Abstract

The 5% 5‐fluorouracil (5‐FU) cream, considered the gold standard topical treatment, and peeling using 70% glycolic acid (GA) followed by 5% 5‐FU are methods for the treatment of actinic keratoses (AKs). However, the comparison of these two treatments had not yet been described and therefore was the objective of this study. A randomized clinical trial, intrapatient study in which 17 patients received a type of treatment in the right and left upper limb with 5% 5‐FU cream (twice daily) or a peeling application of 70% GA (every 15 days) followed by 5% 5‐FU cream. There was a significant reduction of 75% and 85.71% in the mean number of AK lesions and of 74.5% and 85.71% in the size of lesions on the upper limbs of patients treated with peeling and 5% 5‐FU cream (P‐value ≤.001), respectively. Neither treatment was superior to the other since there was no significant difference (P‐value ≥.05) between the treatments, both at the post‐intervention period as well as when comparing the difference between the pre and post‐intervention periods. The peeling with 70% GA followed by 5% 5‐FU as well as 5% 5‐FU cream are effective methods for the treatment of AKs on upper limbs.

Efficacy and safety of 0.5% colchicine cream versus 5% 5-fluorouracil cream in the treatment of cutaneous field cancerization: a randomized clinical trial

“…Regarding the treatment of AK in the upper limbs, a self-controlled clinical trial compared the use of 5% 5-FU cream twice a day in two 15-day cycles separated by a 15-day break versus four fortnightly sessions of 70% glycolic acid peeling + 5% 5-FU solution, indicating an 85.7% reduction in the number of AK in the limbs treated with 5-FU cream. 24 The smaller sample size of the aforementioned study, the treatment area including the hands, as well as the different doses, which may interfere with adherence to treatment, are characteristics that may explain the slightly favorable difference in relation to the 75% reduction in AK count found in the present study.…”

Accelerating patient recruitment using social media: Early adopter experience from a good clinical practice-monitored randomized controlled phase I/IIa clinical trial on actinic keratosis

“…When comparing online recruitment to traditional offline recruitment strategies, online strategies appear more time-efficient. Our review of the published literature on AK from the past 10 years highlighted the time efficiency of an online recruitment approach for RCTs in dermato-oncology ( Table 2 ) [ [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] ]. A review by Jacques RM et al of the recruitment rates using conventional strategies in 388 RCTs between 1997 and 2020 found that the median patient recruitment rate per site was 0.95 per month (0.03 per day) [ 41 ].…”