Peel bond strength of resilient liner modified by the addition of antimicrobial agents to denture base acrylic resin

Abstract

In order to prolong the clinical longevity of resilient denture relining materials and reduce plaque accumulation, incorporation of antimicrobial agents into these materials has been proposed. However, this addition may affect their properties.ObjectiveThis study evaluated the effect of the addition of antimicrobial agents into one soft liner (Soft Confort, Dencril) on its peel bond strength to one denture base (QC 20, Dentsply). Material and MethodsAcrylic specimens (n=9) were made (75x10x3 mm) and stored in distilled water at 37ºC for 48 h. The drug powder concentrations (nystatin 500,000U - G2; nystatin 1,000,000U - G3; miconazole 125 mg - G4; miconazole 250 mg - G5; ketoconazole 100 mg - G6; ketoconazole 200 mg - G7; chlorhexidine diacetate 5% - G8; and 10% chlorhexidine diacetate - G9) were blended with the soft liner powder before the addition of the soft liner liquid. A group (G1) without any drug incorporation was used as control. Specimens (n=9) (75x10x6 mm) were plasticized according to the manufacturers' instructions and stored in distilled water at 37ºC for 24 h. Relined specimens were then submitted to a 180-degree peel test at a crosshead speed of 10 mm/min. Data (MPa) were analyzed by analysis of variance (α=0.05) and the failure modes were visually classified. ResultsNo significant difference was found among experimental groups (p=0.148). Cohesive failure located within the resilient material was predominantly observed in all tested groups. ConclusionsPeel bond strength between the denture base and the modified soft liner was not affected by the addition of antimicrobial agents.

Effect of composition of experimental fluorinated soft lining materials on bond strength to denture base resin

“…Therefore, cohesive failures provide information related to the material strength rather than to the bond between materials. However, mixed and adhesive failures were observed in some specimens, indicating that the cohesive strength values of the lining materials and bond strength values to base resin were similar 40) . In shear bond strength testing, all MB specimens exhibited mixed failures, whereas the VS specimens and all of the experimental materials exhibited cohesive failures.…”

Comparison of the Effect of Nystatin and Titanium Dioxide Addition on Candida Colonization in Soft Lining Material

“…2 According to the literature, this condition occurs in between 11% and 67% of denture wearers. [3][4][5] Local factors associated with dentures are also connected with denture stomatitis, such as the presence of a biofilm, [6][7][8][9] local trauma caused by dentures, 10 xerostomia, 11 continuous use of dentures, 12 and alteration in the salivary pH. 12 Soft denture liners, namely soft polymers, can be applied to the mucosal or fitting area of the dentures.…”

“…28 In a study of the antimycotic action of nystatin-impregnated soft denture lining materials and the influence of 8 an aqueous environment on the fungicidal characteristics, Truhlar et al 6 showed that doses of 1,000,000 U and 500,000 U were useful in maintaining the drug-leaching quantity above the minimum inhibitory concentration for antifungal action. Radnai et al 12 demonstrated that miconazole gel, combined with a Viscogel tissue conditioner, restricted the emergence of C.…”

“…All the drugs were released by the tissue conditioner and restricted the growth of Candida; the best performance was observed using nystatin. 32 Various treatments are available for denture stomatitis, including topical fungicidal and systemic therapy, oral hygiene, and denture hygiene, 8,33 in addition to the replacement of old dentures, treatment of anatomic disorders, re-establishment of a traumatic occlusion, and nutritional restitution. 34 The removal of dentures while sleeping can also help to maintain the health of the mucosal epithelium.…”

“…Thus, various methods are used to eliminate microorganisms from the surface of dentures. 8 Martínez-Beneyto et al 35 showed that the most 9 recommended fungicidal agent was miconazole (prescribed by 59.3% of the survey's respondents), followed by nystatin (57.7%) for topical use. Uchimaru et al 24 reported that TiO 2 , which is a stable photocatalyst, combined with a tissue conditioner exhibited antimicrobial activity against Escherichia coli, S. mutans, and S. aureus, and antifungal activity against C. albicans.…”