Pedunculated, papillary giant cell fibroma in a pediatric patient: An immunohistochemical and in situ hybridization study

Silveira, Heitor Albergoni; Silva-Sousa, Yara Teresinha Corrêa; Reyes, Magdalena Raquel Torres; Bernardini, Vanessa da Rocha; Floriam, Luis José

doi:10.1016/j.pdj.2023.01.005

Cited by 1 publication

(8 citation statements)

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“…This finding is relevant, considering that GCF is considered an FH variant. 1 In the oral cavity, several cases diagnosed as elastofibromatous lesions or elastofibroma, clinically mimicking FH and leukoplakia, have been reported. Most cases appear to be strongly related to trauma or irritation.…”

Section: Discussionmentioning

confidence: 99%

“…1 In fact, by immunohistochemistry, only vimentin is uniformly expressed. 1 Clinical differential diagnosis includes retrocuspid papillae, squamous papilloma, and verruciform xanthoma. By microscopy, cutaneous (fibrous papule, ungual fibroma, and acral fibrokeratoma) and mucosal (retrocuspid papillae and pearly penile papules) lesions should be considered in the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…1 GCF is more prevalent in young adult Whites, with slight female predilection, often involving the gingiva, palate, and tongue. 1 Amalgam tattoo (AT), also known as localized argyria or local argyrosis, forms as a result of entry of dental amalgam into the oral mucosa, frequently gingiva and alveolar ridge, clinically presenting as a gray or black area. 2,3 The connective tissue matrix in GCF and AT is well recognized and typical; however, we have recently observed large areas containing elastofibromatous changes 4,5 in these two lesions, which are very unusual findings.…”

Section: Introductionmentioning

confidence: 99%

“…Giant cell fibroma (GCF) is a benign fibrous proliferation, accounting for 2%–5% of all intraoral reactive/benign fibrous lesions. GCF represents a variant of fibrous hyperplasia (FH), a common intraoral lesion 1 . GCF is more prevalent in young adult Whites, with slight female predilection, often involving the gingiva, palate, and tongue 1 .…”

Section: Introductionmentioning

confidence: 99%

“…GCF represents a variant of fibrous hyperplasia (FH), a common intraoral lesion 1 . GCF is more prevalent in young adult Whites, with slight female predilection, often involving the gingiva, palate, and tongue 1 . Amalgam tattoo (AT), also known as localized argyria or local argyrosis, forms as a result of entry of dental amalgam into the oral mucosa, frequently gingiva and alveolar ridge, clinically presenting as a gray or black area 2,3 .…”

Section: Introductionmentioning

confidence: 99%

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Elastofibromatous changes in giant cell fibroma and amalgam tattoo: Unusual findings in common oral lesions

Silva,

Martins,

Reyes

et al. 2024

J Cutan Pathol

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Several cases of elastofibromatous lesion affecting the oral mucosa have been reported. Clinically, these lesions may appear as small exophytic lesions or less often as white lesions. Therefore, fibrous hyperplasia and leukoplakia are not uncommonly considered in clinical differential diagnosis. Microscopically, elastic and fibrous connective tissue deposition is seen. Rarely, elastofibromatous changes can be detected when assessing intraoral lesions, including cysts, salivary gland neoplasms, and epithelial dysplasia. Here we report two oral lesions showing elastofibromatous changes, expanding their clinicopathological spectrum. The first case was a 46‐year‐old man with a history of asymptomatic nodular lesion on the palate 1 year ago, diagnosed as giant cell fibroma with elastofibromatous changes. The second case was a 79‐year‐old woman who presented a pigmented and mildly symptomatic lesion on the mandibular alveolar mucosa several months ago, diagnosed as amalgam tattoo associated with elastofibromatous changes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%