Pedunculated carcinoma ex pleomorphic adenoma of the nasal cavity

Abstract

Background:A carcinoma ex pleomorphic adenoma (CXPA) is an epithelial malignancy arising in or from a benign pleomorphic salivary adenoma. The parotid gland is the most common location of CXPAs. Minor salivary gland CXPAs of the nasal cavity are exceedingly rare, with only 6 documented in the literature.Methods and Result:We present a 7th case: an unusual pedunculated intranasal CXPA, which had a favorable outcome after a wide endoscopic excision and the longest follow-up period reported to date. The clinical features, immunohistochemical characteristics, treatment choices, and disease outcomes of the intranasal CXPAs reported in previous studies are also reviewed.Conclusion:This case demonstrates the importance of considering the possibility of CXPA in the differential diagnosis of minor salivary gland malignancies in the nasal cavity.

Nasopharyngeal carcinoma ex-pleomorphic adenoma (noninvasive): A report of a rare case

“…Noninvasive and minimally invasive CXPA does not behave like a malignant lesion. [ 1 6 7 ] In our case, the malignant focus was confined within the PA. Hence, we considered it as a noninvasive CXPA.…”

“…A CXPA is a malignant epithelial neoplasm which takes origin from either a primary or a recurrent benign PA. CXPA is extremely rare in the nasopharyngeal regions, with <20 reported cases in the English literature. [ 1 3 6 7 ]…”

Nasopharyngeal Carcinoma Ex Pleomorphic Adenoma: Case Report and Comprehensive Literature Review

“…Tumors in the nasopharynx and sinonasal region arise from minor salivary glands in this region and tend to be more aggressive with a higher rate recurrence. However, this is based on very limited available data [ 2 ]. Due to the rarity of disease, the exact pathogenesis of transformation is unknown.…”

“…Carcinoma ex pleomorphic adenoma (CXPA) is a carcinoma arising from a primary or recurrent benign pleomorphic adenoma (PA) and accounts for approximately 12% of all malignant salivary carcinomas. However, its occurrence in the nasopharynx is exceedingly rare [1][2][3]. CXPA generally occurs in the 5 th to 8 th decade of life and is more common in females [4].…”