PedsQL Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in Pediatric Patients with Inflammatory Bowel Disease in Comparison with Healthy Controls

Varni, James W.; Franciosi, James P.; Shulman, Robert J.; Saeed, Shehzad Ahmed; Nurko, Samuel; Neigut, Deborah A.; Bendo, Cristiane Baccin; Patel, Ashish; Self, Mariella M.; Saps, Miguel; Zacur, George M.; Denham, Jolanda; Dark, Chelsea Vaughan; Pohl, John F.

doi:10.1097/mib.0000000000000351

Cited by 39 publications

(39 citation statements)

References 50 publications

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“…Chouliaras et al [25] reported in pediatrics, CD patients had better QoL than UC patients although they did not reach statistical significance. Another pediatric study reported there were no significant differences in the quality of life (PedsQL) scores between pediatric CD and UC [38]. In contrast, this present finding demonstrated patients with CD had a significantly better QoL than patients with UC in terms of the physical well-being, emotional well-being, school performance, self-esteem, family, prolong illness, and total QoL score (KINDL R score).…”

Section: Discussioncontrasting

confidence: 87%

The Relationship Between Sleep Disturbance and Disease Activity in Pediatric Patients With Inflammatory Bowel Disease

Jarasvaraparn¹,

Zlomke²,

Vann³

et al. 2019

J. pediatr. gastroenterol. nutr.

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Background: Pediatric patients with inflammatory bowel disease (IBD) are at risk for psychiatric symptoms that impact quality of life (QoL) and psychosocial functioning. Sleep disturbance has been reported to impose adverse effects on host defense mechanisms by affecting the magnitude and characteristics of the inflammatory response. The current study sought to assess the relationships among sleep disturbance, QoL, and psychosocial functioning in children with IBD. Methods: Pediatric IBD patients completed multiple measures of sleep and daytime functioning as well as measures of QoL and psychosocial functioning. The parents completed complementary measures of sleep, QoL, and psychosocial functioning. The HRQOL results for subjects with IBD were compared to a healthy control group. Results: Fifty-three children with pediatric IBD and their parents were enrolled in the study. QoL was positively associated with sleep quality, based on significant negative correlations between QoL and both sleep quality and daytime sleepiness scales (r = −0.62, −0.57; p value <0.001, respectively). Patients with CD reported significantly better QoL and psychosocial functioning than patients with UC. The QoL was similar between IBD patients and healthy controls. Conclusions: The present study suggests that a positive association exists between sleep functioning and QoL in pediatric patients with IBD. Patients with pediatric IBD should be screened for sleep disturbance, QoL and psychosocial functioning. Prevention and intervention strategies of sleep disturbance aimed at improving QoL and psychosocial functioning in children with IBD should be developed and evaluated.

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Section: Discussioncontrasting

confidence: 87%

The Relationship Between Sleep Disturbance and Disease Activity in Pediatric Patients With Inflammatory Bowel Disease

Jarasvaraparn¹,

Zlomke²,

Vann³

et al. 2019

J. pediatr. gastroenterol. nutr.

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“…4,5 Although IBD is not believed to have a psychosocial origin, a number of studies have identified psychosocial variables associated with the disease, 6-8 some of which clearly have the potential for significantly affecting the quality of life of IBD patients. 9-11 Comparing children with IBD to matched controls, researchers have found more anxiety, depression, social functioning (inter-personal interactions in social situations) problems and family dysfunction in those with IBD. 7 Many studies have found depression in particular is increased in youth with IBD compared to controls 7 and parents of children with IBD also show increased levels of depression.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Cognitive Behavioral Therapy Intervention Trial to Improve Disease Outcomes in Children with Inflammatory Bowel Disease

Levy

Tilburg

Langer

et al. 2016

Inflammatory Bowel Diseases

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Background Studies testing the efficacy of behavioral interventions to modify psychosocial sequelae of IBD in children are limited. This report presents outcomes through a six month follow up from a large RCT testing the efficacy of a cognitive-behavioral intervention for children with IBD and their parents. Methods 185 children age 8-17 years with a diagnosis of Crohn's (CD) or Ulcerative Colitis (UC) and their parents were randomized to one of two 3-session conditions: 1.) a social learning and cognitive-behavioral therapy condition (SLCBT) or 2.) an education support condition designed to control for time and attention. Results There was a significant overall treatment effect for school absences due to CD or UC (p<.05) at 6 months post-treatment. There was also a significant overall effect post-treatment for child-reported quality of life (p<.05), parent- reported increases in adaptive child coping (p<.001) and reductions in parents’ maladaptive responses to children's symptoms (p<.05). Finally, exploratory analyses indicated that for children with a higher level of flares (2 or more) pre-baseline, those in SLCBT experienced a greater reduction in flares post-treatment. Conclusions This trial suggests that a brief cognitive-behavioral intervention for children with IBD and their parents can result in improved child functioning and quality of life, and for some children may decrease disease activity.

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“…A thorough QOL evaluation should include the evaluation of all of these dimensions. Varni et al have also developed numerous disease specific scales [22][23][24][25][26] . A cancer module of PedsQL is also available for children with cancer 19 .…”

Section: Discussionmentioning

confidence: 99%

Kanserli ve kronik hastalığı olan çocuklarda yaşam kalitesi

Yağcı-Küpeli¹,

Akın

Usluoğlu³

et al. 2019

Cukurova Medical Journal

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Health related quality of life (HRQOL) concept is one of the major outcome measures in management of chronic diseases in children. Herein we aimed to review HRQOL by using PedsQL Generic Core Scales in children with cancer and chronic diseases. Materials and Methods: All patients with cancer under treatment (oncology group), attention deficit hyperactivity disorder (ADHD), nephrological disorders like recurrent urinary tract infections and other endocrinologic disorders such as precocious puberty and growth retardation and their parents who gave consent were included in the study. Turkish version of PedsQL 4.0 Generic Core Scales self and parent proxy-reports were used for all patients of 8-12 and 13-18 years of age. Results: There were 48 children in oncology group; 44 in non-oncology group. The most common diagnoses were leukemia, non-Hodgkin lymphoma and brain tumors in the oncology group. Children reported significantly higher scores in the school subscale and physical functioning subscale, psychosocial functioning, and total scale scores in the non-oncology group compared to patients with cancer. A strong positive significant correlation was detected between all subscales except for social functioning scores of children and parents in child selfreport and parent proxy-report correlations. Conclusion: Cancer is a devastating disease that impair functioning more than other chronic diseases in all areas of life of children and parents. PedsQL Genereric Core Scales is a usefull tool for evaluating HRQOL in both cancer and other chronic diseases.

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PedsQL Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in Pediatric Patients with Inflammatory Bowel Disease in Comparison with Healthy Controls

Abstract: The PedsQL Gastrointestinal Symptoms and Worry Scales may be used as common metrics across pediatric patients with IBD, including Crohn's disease and ulcerative colitis separately to measure gastrointestinal-specific symptoms in clinical research and practice.

Cited by 39 publications

References 50 publications

The Relationship Between Sleep Disturbance and Disease Activity in Pediatric Patients With Inflammatory Bowel Disease

The Relationship Between Sleep Disturbance and Disease Activity in Pediatric Patients With Inflammatory Bowel Disease

Effects of a Cognitive Behavioral Therapy Intervention Trial to Improve Disease Outcomes in Children with Inflammatory Bowel Disease

Kanserli ve kronik hastalığı olan çocuklarda yaşam kalitesi

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