Introduction Latissimus Dorsi (LD) myocutaneous flap is a workhorse flap for various large reconstructions. Variants described to increase its volume are referred to as extended LD flaps. The extended fleur-de-lis LD is one of these variants. We report the clinical outcomes using a modified extended fleur-de-lis LD flap for complex multi-directional soft and bone tissue defects. Methods Between 2010 and 2017, 29 patients underwent the modified extended fleur-de-lis LD flaps, whose sizes were between 120 cm 2 and 442 cm 2. The mean age was 47.55 ± 9.07 years. Locations of the defects included head and neck (nine cases), upper extremity (six cases), lower extremity (nine cases) and chest wall regions (five cases).