Pediatric use of intravenous amiodarone: Efficacy and safety in critically III patients from a multicenter protocol

Perry, JC; Fenrich, AL; Hulse, J.Edward; Jk, Triedman; Friedman, RA; Lamberti, JJ

doi:10.1016/0735-1097(95)00591-9

Cited by 173 publications

(16 citation statements)

References 13 publications

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“…In 4 small LOE 4 pediatric case series 298,299,314,315 amiodarone was effective in the management of VT. One prospective randomized multicenter safety and efficacy LOE 2 trial evaluating amiodarone for the treatment of pediatric tachyarrhythmias 316 found that 71% of children treated with amiodarone experienced cardiovascular side effects. Both efficacy and adverse events were dose-related.…”

Section: Arrhythmia Therapypeds-030mentioning

confidence: 94%

“…Evidence from 2 LOE 5 case series in children 298,299 supported the effectiveness of amiodarone for the treatment and acute conversion of life-threatening (non-arrest) ventricular arrhythmias. There are no pediatric data investigating the efficacy of lidocaine for shock refractory VF/ pulseless VT.…”

Section: Defibrillationmentioning

confidence: 97%

“…One LOE 4 randomized, prospective study 316 and 15 LOE 4 small case series and observational studies in infants and children 298,299,314,315,347–357 showed that amiodarone was effective in the treatment of supraventricular tachyarrhythmias. Generalization to pediatric SVT treatment with amiodarone may be limited, however, since most of these studies in children involved postoperative junctional tachycardia.…”

Section: Arrhythmia Therapypeds-030mentioning

confidence: 99%

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Part 10: Pediatric Basic and Advanced Life Support

Kleinman

Caen

Chameides³

et al. 2010

Circulation

183

184

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Note From the Writing Group: Throughout this article, the reader will notice combinations of superscripted letters and numbers (eg, “Family Presence During ResuscitationPeds-003”). These callouts are hyperlinked to evidence-based worksheets, which were used in the development of this article. An appendix of worksheets, applicable to this article, is located at the end of the text. The worksheets are available in PDF format and are open access.

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Section: Arrhythmia Therapypeds-030mentioning

confidence: 94%

Section: Defibrillationmentioning

confidence: 97%

Section: Arrhythmia Therapypeds-030mentioning

confidence: 99%

See 1 more Smart Citation

Part 10: Pediatric Basic and Advanced Life Support

Kleinman

Caen

Chameides³

et al. 2010

Circulation

183

184

View full text Add to dashboard Cite

show abstract

“…Evidence from 2 LOE 5 case series in children 298,299 supported the effectiveness of amiodarone for the treatment and acute conversion of life-threatening (nonarrest) ventricular arrhythmias. There are no pediatric data investigating the efficacy of lidocaine for shock refractory VF/pulseless VT.…”

Section: Defibrillationmentioning

confidence: 97%

Pediatric Basic and Advanced Life Support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

Kleinman¹,

Caen²,

Chameides³

et al. 2010

Pediatrics

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“…Experts at the 2005 Consensus Conference reviewed the available evidence on use of the tracheal tube and LMA in infants and children. [59] There were no data on the use of the Combitube in this age group.…”

Section: Initial Steps Of Cprmentioning

confidence: 99%

Better outcome after pediatric resuscitation is still a dilemma

Sahu

Kishore

Lata

2010

J Emerg Trauma Shock

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Pediatric cardiac arrest is not a single problem. Although most episodes of pediatric cardiac arrest occur as complications and progression of respiratory failure and shock. Sudden cardiac arrest may result from abrupt and unexpected arrhythmias. With a better-tailored therapy, we can optimize the outcome. In the hospital, cardiac arrest often develops as a progression of respiratory failure and shock. Typically half or more of pediatric victims of in-hospital arrest have pre-existing respiratory failure and one-third or more have shock, although these figures vary somewhat among reporting hospitals. When in-hospital respiratory arrest or failure is treated before the development of cardiac arrest, survival ranges from 60% to 97%. Bradyarrthmia, asystole or pulseless electric activity (PEA) were recorded as an initial rhythm in half or more of the recent reports of in-hospital cardiac arrest, with survival to hospital discharge ranging from 22% to 40%. Data allowing characterization of out of hospital pediatric arrest are limited, although existing data support the long-held belief that as with hospitalized children, cardiac arrest most often occurs as a progression of respiratory failure or shock to cardiac arrest with bradyasystole rhythm. Although VF (Ventricular fibrillation, is a very rapid, uncoordinated, ineffective series of contractions throughout the lower chambers of the heart. Unless stopped, these chaotic impulses are fatal) and VT (Ventricular tachycardia is a rapid heartbeat that originates in one of the ventricles of the heart. To be classified as tachycardia, the heart rate is usually at least 100 beats per minute) are not common out-of-cardiac arrest in children, they are more likely to be present with sudden, witnessed collapse, particularly among adolescents. Pre-hospital care till the late 1980s was mainly concerned with adult care, and the initial focus for pediatric resuscitation was provision of oxygen and ventilation, with initial rhythm at the time of emergency medical services arrival being infrequently recorded. In the 1987 series, pre-hospital pediatric cardiac arrest demonstrated asystole in 80%, PEA in 10.5% and VF or VT in 9.6%. Only 29% arrests were witnessed, however, and death in many victims was caused by sudden infant death syndrome.

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Pediatric use of intravenous amiodarone: Efficacy and safety in critically III patients from a multicenter protocol

Abstract: Intravenous amiodarone is safe and effective in most young patients with critical tachyarrhythmia. Intravenous amiodarone can be lifesaving, particularly for postoperative junctional ectopic tachycardia, when standard therapy is ineffective.

Cited by 173 publications

References 13 publications

Part 10: Pediatric Basic and Advanced Life Support

Part 10: Pediatric Basic and Advanced Life Support

Pediatric Basic and Advanced Life Support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

Better outcome after pediatric resuscitation is still a dilemma

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