Pediatric Urinary Tract Infections

Chang, Steven L.; Shortliffe, Linda D.

doi:10.1016/j.pcl.2006.02.011

Cited by 246 publications

(227 citation statements)

References 116 publications

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“…The incidence of Candida UTIs in hospitalized pediatric patients has been increased during the recent years (31). In the present study, the frequency of candiduria was higher among children than adults (62% vs 25.4%, P = 0.001) (Table 1).…”

Section: Discussionsupporting

confidence: 49%

Nosocomial Candiduria in Critically Ill Patients Admitted to Intensive Care Units in Qazvin, Iran

Ghiasian

Aghamirian²,

Eshghi

2014

Avicenna J Clin Microbiol Infect

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Background: A broad variety of fungi, especially Candida species, are becoming increasingly common causes of urinary tract infections in hospital settings. Objectives: The current cross-sectional descriptive study aimed to determine the causative agents, risk factors and incidence rate of candiduria in critically ill patients, hospitalized in intensive care units (ICUs) of four Iranian hospitals. Patients and Methods: A total of 155 children and adult patients, admitted to ICUs of the four university educational hospitals, who demonstrated Candida-positive urine cultures, were examined. Samples were processed via mycological procedures by direct microscopy and culture. Results: Candiduria was confirmed in 50 (32.26 %) patients and Candida albicans was the most frequently isolated species representing 60.0% of isolates, followed by 14.0% C. glabrata, 12.0% C. parapsilosis, 10.0% C. krusei, and 4.0% C. tropicalis. Most patients were female (58%) with a mean age of 46.7 years old. Generally, 39.7% and 62% of adults and children showed candiduria, respectively. The commonest predisposing factors were antibiotic therapy (98.0%), urinary catheterization (92.0%), corticotherapy (84.0%), being female (42.6 %), use of feeding tube (56%), and extended hospitalization, respectively. Conclusions: The high frequency of candiduria in ICU patients can be decreased by shortening the duration of urinary catheterization, avoiding extra antibiotics and corticosteroids, as well as controlling the predisposing factors and underlying conditions.

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Section: Discussionsupporting

confidence: 49%

Nosocomial Candiduria in Critically Ill Patients Admitted to Intensive Care Units in Qazvin, Iran

Ghiasian

Aghamirian²,

Eshghi

2014

Avicenna J Clin Microbiol Infect

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“…Also, they were 1-3 years old. During the first year of life, boys have a higher incidence of UTIs; in all other age groups, girls are more prone to develop UTIs (29). Higher incidence of UTIs in uncircumcised boys has been reported previously (30).…”

Section: Discussionmentioning

confidence: 76%

Molecular Characterization and Antimicrobial Resistance of Uropathogenic Escherichia coli

et al. 2014

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Background: Urinary Tract Infections (UTIs) are the most common infectious diseases in childhood. The Uropathogenic Escherichia coli (UPEC) strains account for as much as 80% of UTIs. Objective: From a clinical perspective, it is important to know which virulence factors and antibiotic resistance properties are present in UPEC strains in pediatrics. Therefore, this study was carried out to investigate the molecular characterization and antimicrobial resistance of UPEC strains isolated from hospitalized patients in pediatric ward of Baqiyatallah Hospital in Tehran. Patients and Methods: One hundred and twenty-one urine specimens were collected from the patients infected with UTIs (51 boys and 70 girls). The urine samples were cultured immediately, and those with E. coli-positive were analyzed for the presence of antibiotic resistance genes and bacterial virulence factors using Polymerase Chain Reaction (PCR). Also, antimicrobial susceptibility testing was performed using disk diffusion methodology with Mueller-Hinton agar according to the instruction of Clinical Laboratory and Standard Institute. Results: Nineteen out of 51 (37.25%) urine samples from boys and 47 out of 70 (67.14%) urine samples from girls harbored E. coli. A significant difference was found between the frequency of UPEC strains in boys and girls (P <.05). High resistance levels to tetracycline (69.6%), ampicillin (69.6%) and norfloxacin (63.6%) were also observed. Totally, 1.66% of tested strains were resistant to more than 8 antibiotics. The incidence of genes encoding resistance against gentamicin (aac (3)-IV), sulfonamide (sul1), beta-lactams (blaSHV and CITM), tetracycline (tetA and tetB), trimethoprim (dfrA1), and quinolones (qnr) were 25. 7%, 22.7%, 83.2%, 71.1%, 19.6% and 21.2%, respectively. The most commonly detected virulence factors were fim (71.2%), set-1 (66.6%), iha (62.1), papGI (59%), usp (56%) and sen (22.7%). Conclusion: Resistant strains of uropathogenic E. coli had the lower incidence of uropathogenic virulence factors. We suggested prescription of imipenem and amikacin to treat pediatric patients infected with UTIs.

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“…Furthermore in the studies by Lee et al [12] and Chang et al [13] showed a male predominance. Ghaemi et al [11] found that nearly 60% of male infants with UTI were uncircumcised and Singh-Grewal et al [14] found that circumcision was associated with a significantly reduced risk of UTI.…”

Section: Discussionmentioning

confidence: 90%

“…In a retrospective study performed by Singh-Grewal et al [13] reported that infection with E-coli had a stronger association with conjugated than unconjugated hyperbilirubinemia. Such association was not found with Klebsiella pneumonia infection.…”

Section: Discussionmentioning

confidence: 99%

Hyperbilirubinemia with Urinary Tract Infection in Infants Younger Than Eight Weeks Old

Rashed¹

2014

JPNC

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Pediatric Urinary Tract Infections

Cited by 246 publications

References 116 publications

Nosocomial Candiduria in Critically Ill Patients Admitted to Intensive Care Units in Qazvin, Iran

Nosocomial Candiduria in Critically Ill Patients Admitted to Intensive Care Units in Qazvin, Iran

Molecular Characterization and Antimicrobial Resistance of Uropathogenic Escherichia coli

Hyperbilirubinemia with Urinary Tract Infection in Infants Younger Than Eight Weeks Old

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