Pediatric tympanic membrane cholesteatoma: Systematic review and meta-analysis

Ching, Harry H.; Spinner, Alycia G.; Ng, Michael K.

doi:10.1016/j.ijporl.2017.08.027

Cited by 12 publications

(24 citation statements)

References 21 publications

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“…Intratympanic membrane cholesteatoma can occur through metaplasia within the tympanic membrane caused by local inflammation. 5 Tympanosclerosis can induce symptoms such as conductive hearing loss, whereas intratympanic membrane cholesteatoma usually is asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical removal is recommended for cholesteatoma because it could progress and involve the middle ear. 5 In contrast, for tympanosclerosis, surgical treatment is not necessary if the lesion is limited within the tympanic membrane and the patient has no conductive hearing loss. This case is significant because it demonstrates that tympanosclerosis can appear as a focal mass mimicking an intratympanic membrane cholesteatoma in a young patient.…”

Section: Discussionmentioning

confidence: 99%

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Tympanosclerosis Presenting as Intratympanic Focal Mass in a 14‐Year‐Old Girl

Jeong

2022

OTO Open

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tympanosclerosis Presenting as Intratympanic Focal Mass in a 14‐Year‐Old Girl

Jeong

2022

OTO Open

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“…Mesotympanic congenital cholesteatoma, are found within the middle ear cavity and are thought to form from a remnant epidermoid cyst without involvement of the ear drum (L. Michaels, ). In contrast, TM cholesteatoma are confined to the ear drum, and at earlier stages only to the outer layer of the eardrum (Ching, Spinner, & Ng, ). Their etiology, and its relation to TM development, remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Developmental aspects of the tympanic membrane: Shedding light on function and disease

Mozaffari

Jiang

Tucker

2019

Genesis

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Summary The ear drum, or tympanic membrane (TM), is a key component in the intricate relay that transmits air‐borne sound to our fluid‐filled inner ear. Despite early belief that the mammalian ear drum evolved as a transformation of a reptilian drum, newer fossil data suggests a parallel and independent evolution of this structure in mammals. The term “drum” belies what is in fact a complex three‐dimensional structure formed from multiple embryonic cell lineages. Intriguingly, disease affects the ear drum differently in its different parts, with the superior and posterior parts being much more frequently affected. This suggests a key role for the developmental details of TM formation in its final form and function, both in homeostasis and regeneration. Here we review recent studies in rodent models and humans that are beginning to address large knowledge gaps in TM cell dynamics from a developmental biologist's point of view. We outline the biological and clinical uncertainties that remain, with a view to guiding the indispensable contribution that developmental biology will be able to make to better understanding the TM.

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“…IMCC is a rare finding with limited information. It is unclear whether IMCC is congenital, but a systemic review supported it for following findings 1 : First, most patients in previously reported cases denied prior otitis media. Second, the reported patients were generally less than 3 years of age.…”

mentioning

confidence: 99%

“…Simple enucleation is suggested as the first choice for treatment of IMCC since there is no statistical difference in recurrence or complications between the two surgical procedures, enucleation and complete excision with TM. 1 A sharp approach is required to detach the outer squamous layer from the middle fibrous layer for successful enucleation. The magnified clear vision provided by the endoscopic system enables operators to perform delicate procedures and remove lesions without damaging surrounding structures.…”

mentioning

confidence: 99%