Pediatric traumatic brain injury: Language outcomes and their relationship to the arcuate fasciculus

Liégeois, F; Mahony, Kate; Connelly, Alan; Pigdon, Lauren; Tournier, Jacques‐Donald; Morgan, Angela

doi:10.1016/j.bandl.2013.05.003

Cited by 27 publications

(17 citation statements)

References 72 publications

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“…For each participant, seed and target ROIs were drawn on the right and left hemispheres, in native space, according to a set protocol based on Liégeois et al (2013) . The seed was placed in the dorsal portion of the AF, approximating the location of the arcuate fasciculus ‘bottleneck’ (as in Galantucci et al, 2011 ), posterior to the central sulcus, while avoiding being directly inferior to cortico-spinal descending tracts.…”

Section: Methodsmentioning

confidence: 99%

Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI

2015

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Section: Methodsmentioning

confidence: 99%

Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI

2015

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“…CSD-PT is often applied to the study of motor and language tracts. For example, Liégeois et al ( 11 , 12 ) studied which tractography-derived measures best predicted language outcome and presence of dysarthria long term after childhood brain traumatic injury. Northam et al ( 13 ) evaluated the relationship between WM microstructure and speech deficits in very adolescents born very preterm (VPT), with a spectrum of brain injuries.…”

Section: Introductionmentioning

confidence: 99%

Improvement in White Matter Tract Reconstruction with Constrained Spherical Deconvolution and Track Density Mapping in Low Angular Resolution Data: A Pediatric Study and Literature Review

et al. 2017

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IntroductionDiffusion-weighted magnetic resonance imaging (DW-MRI) allows noninvasive investigation of brain structure in vivo. Diffusion tensor imaging (DTI) is a frequently used application of DW-MRI that assumes a single main diffusion direction per voxel, and is therefore not well suited for reconstructing crossing fiber tracts. Among the solutions developed to overcome this problem, constrained spherical deconvolution with probabilistic tractography (CSD-PT) has provided superior quality results in clinical settings on adult subjects; however, it requires particular acquisition parameters and long sequences, which may limit clinical usage in the pediatric age group. The aim of this work was to compare the results of DTI with those of track density imaging (TDI) maps and CSD-PT on data from neonates and children, acquired with low angular resolution and low b-value diffusion sequences commonly used in pediatric clinical MRI examinations.Materials and methodsWe analyzed DW-MRI studies of 50 children (eight neonates aged 3–28 days, 20 infants aged 1–8 months, and 22 children aged 2–17 years) acquired on a 1.5 T Philips scanner using 34 gradient directions and a b-value of 1,000 s/mm2. Other sequence parameters included 60 axial slices; acquisition matrix, 128 × 128; average scan time, 5:34 min; voxel size, 1.75 mm × 1.75 mm × 2 mm; one b = 0 image. For each subject, we computed principal eigenvector (EV) maps and directionally encoded color TDI maps (DEC-TDI maps) from whole-brain tractograms obtained with CSD-PT; the cerebellar-thalamic, corticopontocerebellar, and corticospinal tracts were reconstructed using both CSD-PT and DTI. Results were compared by two neuroradiologists using a 5-point qualitative score.ResultsThe DEC-TDI maps obtained presented higher anatomical detail than EV maps, as assessed by visual inspection. In all subjects, white matter (WM) tracts were successfully reconstructed using both tractography methodologies. The mean qualitative scores of all tracts obtained with CSD-PT were significantly higher than those obtained with DTI (p-value < 0.05 for all comparisons).ConclusionCSD-PT can be successfully applied to DW-MRI studies acquired at 1.5 T with acquisition parameters adapted for pediatric subjects, thus providing TDI maps with greater anatomical detail. This methodology yields satisfactory results for clinical purposes in the pediatric age group.

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“…A further 39 papers were excluded on this basis, with another eight reporting multivariate statistics (general linear models, ANOVAs) (Adamson et al, 2013;Liégeois et al, 2013;Mayer et al, 2012;Treble et al, 2013;Wilde et al, 2006;Wilde, Hunter, & Bigler, 2012;Wilde et al, 2010;Wozniak et al, 2007), rather than univariate correlations. The corresponding authors for these eight studies were subsequently contacted to request the relevant data.…”

Section: Literature Searchmentioning

confidence: 99%

Relationship Between Diffusion Tensor Imaging (DTI) Findings and Cognition Following Pediatric TBI: A Meta-Analytic Review

Roberts

Mathias

Rose

2016

Developmental Neuropsychology

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Pediatric traumatic brain injury: Language outcomes and their relationship to the arcuate fasciculus

Cited by 27 publications

References 72 publications

Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI

Contributions of bilateral white matter to chronic aphasia symptoms as assessed by diffusion tensor MRI

Improvement in White Matter Tract Reconstruction with Constrained Spherical Deconvolution and Track Density Mapping in Low Angular Resolution Data: A Pediatric Study and Literature Review

Relationship Between Diffusion Tensor Imaging (DTI) Findings and Cognition Following Pediatric TBI: A Meta-Analytic Review

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