Pediatric transplantation during the COVID-19 pandemic

Kakos, Christos D; Ziogas, Ioannis A.; Tsoulfas, Georgios

doi:10.5500/wjt.v12.i5.88

Cited by 2 publications

(2 citation statements)

References 99 publications

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“…The majority of patients demonstrated mild to moderate levels of disease severity, which is similar to that observed in the general population ( 87 ). A systematic review and meta-analysis suggests that continuing immune suppressive therapy may be safe for SOT recipients with moderate or severe COVID-19 ( 88 ), as it can potentially alleviate the cytokine storm ( 89 ). The decision to adjust the patient's immunosuppressive regimen should be approached individually, with careful consideration given to factors such as disease severity, the specific immunosuppressants administered, the type of transplant, the time since transplantation, the concentration of the drug, and the likelihood of graft rejection and superinfection ( 81 ).…”

Section: Severe Acute Respiratory Syndrome-coronavirus-2 (Sars-cov-2)...mentioning

confidence: 99%

A quick algorithmic review on management of viral infectious diseases in pediatric solid organ transplant recipients

Moghadamnia,

Eshaghi,

Alimadadi

et al. 2023

Front. Pediatr.

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Pediatric solid organ transplant is a life-saving procedure for children with end-stage organ failure. Viral infections are a common complication following pediatric solid organ transplantation (SOT), which can lead to increased morbidity and mortality. Pediatric solid organ transplant recipients are at an increased risk of viral infections due to their immunosuppressed state. The most commonly encountered viruses include cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus (HSV), varicella-zoster virus (VZV), adenoviruses, and BK polyomavirus. Prevention strategies include vaccination prior to transplantation, post-transplant prophylaxis with antiviral agents, and preemptive therapy. Treatment options vary depending on the virus and may include antiviral therapy and sometimes immunosuppression modification. This review provides a Quick Algorithmic overview of prevention and treatment strategies for viral infectious diseases in pediatric solid organ transplant recipient.

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Section: Severe Acute Respiratory Syndrome-coronavirus-2 (Sars-cov-2)...mentioning

confidence: 99%

A quick algorithmic review on management of viral infectious diseases in pediatric solid organ transplant recipients

Moghadamnia,

Eshaghi,

Alimadadi

et al. 2023

Front. Pediatr.

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“…In early 2020, from mid-March to mid-April, in states most severely affected by COVID-19, there were 11% fewer new listings, 49% fewer living donor transplantations, 9% fewer deceased donor liver transplantations, and 59% more deaths while waiting for a transplant than anticipated[ 10 ]. Despite every successive COVID-19 wave inherently carrying different epidemiologic outcomes than those of the first wave, transplant programs seemed to adapt to the changing landscape, as by August of the same year, except for deceased donor liver transplants, rates were within the expected range[ 11 ]. The increased waitlist mortality, particularly during the first few months of 2020, can be explained by a multitude of factors, including deaths from end-stage liver disease while waiting for transplantation, the inability to admit patients facing complications of chronic liver disease, and the particularly severe impact of SARS-CoV-2 on obese patients with concurrent non-alcoholic steatohepatitis listed for transplantation[ 12 ].…”

Section: Liver Transplantation In the Covid-19 Eramentioning

confidence: 99%

Liver transplantation during COVID-19: Adaptive measures with future significance

Gyftopoulos¹,

Ziogas²,

Montenovo³

2022

WJT

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Following the outbreak of coronavirus disease 2019 (COVID-19), a disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the field of liver transplantation, along with many other aspects of healthcare, underwent drastic changes. Despite an initial increase in waitlist mortality and a decrease in both living and deceased donor liver transplantation rates, through the implementation of a series of new measures, the transplant community was able to recover by the summer of 2020. Changes in waitlist prioritization, the gradual implementation of telehealth, and immunosuppressive regimen alterations amidst concerns regarding more severe disease in immunocompromised patients, were among the changes implemented in an attempt by the transplant community to adapt to the pandemic. More recently, with the advent of the Pfizer BNT162b2 vaccine, a powerful new preventative tool against infection, the pandemic is slowly beginning to subside. The pandemic has certainly brought transplant centers around the world to their limits. Despite the unspeakable tragedy, COVID-19 constitutes a valuable lesson for health systems to be more prepared for potential future health crises and for life-saving transplantation not to fall behind.

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Pediatric transplantation during the COVID-19 pandemic

Cited by 2 publications

References 99 publications

A quick algorithmic review on management of viral infectious diseases in pediatric solid organ transplant recipients

A quick algorithmic review on management of viral infectious diseases in pediatric solid organ transplant recipients

Liver transplantation during COVID-19: Adaptive measures with future significance

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