Pediatric Systemic Lupus Erythematous in COVID-19 Era

Lupu, Ancuța; Miron, Ingrith; Gavrilovici, Cristina; Raileanu, Anca Adam; Stârcea, Iuliana Magdalena; Ioniuc, Ileana; Azoicăi, Alice; Mocanu, Adriana; Butnariu, Lăcrămioara Ionela; Dragan, Felicia; Lupu, Vasile Valeriu

doi:10.3390/v15020272

Cited by 7 publications

(6 citation statements)

References 66 publications

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“…However, the development of more severe forms or burdened by complications is not noticeable in them ( 22 ). Similar findings in the reference period were also objectified in the case of other autoimmune pathologies, such as systemic lupus erythematosus, where there was a marked increase in the rate of relapse, diagnosis of new cases and even a decrease in therapeutic control in pre-existing cases ( 23 ).…”

Section: Epidemiologysupporting

confidence: 69%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially in pediatrics, celiac disease (also called gluten enteropathy), is gaining more and more ground in terms of diagnosis, but also interest in research. The data from the literature of the last decades attest the chameleonic way of its presentation, there may be both classic onset symptoms and atypical symptoms. Given the impact played by celiac disease, especially in the optimal growth and development of children, the current narrative review aims to highlight the atypical presentation methods, intended to guide the clinician towards the inclusion of the pathology in the differential diagnosis scheme. To these we add the summary presentation of the general data and therapeutic lines regarding the underlying condition and the existing comorbidities. In order to place the related information up to date, we performed a literature review of the recent articles published in international databases. We bring forward the current theories and approaches regarding both classic celiac disease and its atypical manifestations. Among these we note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, but also disorders of biological constants and association with multiple autoimmunities. Knowing and correlating them with celiac disease is the key to optimal management of patients, thus reducing the subsequent burden of the disease.

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Section: Epidemiologysupporting

confidence: 69%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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“…There is a paucity of literature on the course of COVID-19 in children, particularly those with PRD. Researchers face a multitude of challenges when conducting studies in this population, including several children with asymptomatic COVID-19 and parental reluctance to enroll children in studies during the current pandemic [ 22 ]. It is well known that children are not miniature adults.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of COVID-19 in Pediatric Rheumatic Diseases: 2020–2022 Survey of the Pediatric Rheumatology Association of Japan

Wakiguchi

Kaneko

Sato

et al. 2023

Viruses

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Coronavirus disease 2019 (COVID-19) in children can be compounded by concurrent diseases and immunosuppressants. For the first time, we aimed to report the clinical features of concurrent COVID-19 and pediatric rheumatic disease (PRD) in Japan. Pediatric Rheumatology Association of Japan members were surveyed between 1 April 2020 and 31 August 2022. Outcome measurements included the clinical features of concurrent PRD and COVID-19. Questionnaire responses were obtained from 38 hospitals. Thirty-one hospitals (82%) had children with PRD and COVID-19. The female-to-male ratio in these children (n = 156) was 7:3, with half aged 11–15 years. The highest proportion of children with PRD and COVID-19 was accounted for by juvenile idiopathic arthritis (52%), followed by systemic lupus erythematosus (24%), juvenile dermatomyositis (5%), scleroderma (4%), and Takayasu arteritis (3%). Of children with PRD, a significant majority (97%) were found to be asymptomatic (10%) or presented with mild symptoms (87%) of the COVID-19 infection. No severe cases or deaths were observed. Regarding the use of glucocorticoids, immunosuppressants, or biologics for PRD treatment before COVID-19, no significant difference was found between asymptomatic/mild and moderate COVID-19 in children with PRD. Therefore, COVID-19 is not a threat to children with PRD in Japan.

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“…We found evidence that genome-wide genetic association signatures with severe COVID-19 were associated with signatures of SLE [ 35 ]. The use of immunosuppressive therapies associated with potential comorbidities appears to increase the risk of developing severe COVID-19 in pediatric SLE patients and the adverse outcomes of this disease [ 34 , 36 ]. Patients with SLE are a unique population when considering the risk of COVID-19 infection and the outcome of infection.…”

Section: Discussionmentioning

confidence: 99%

Knowledge mapping of COVID-19 and autoimmune diseases: a visual and bibliometric analysis

Zhang

Jia

et al. 2023

Clin Exp Med

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Background Many studies have shown an association between COVID-19 and autoimmune diseases (ADs). Studies on COVID-19 and ADs have also increased significantly, but there is no bibliometric analysis to summarize the association between COVID-19 and ADs. The purpose of this study was to perform a bibliometric and visual analysis of published studies related to COVID-19 and ADs. Methods Based on the Web of Science Core Collection SCI-Expanded database, we utilize Excel 2019 and visualization analysis tools Co-Occurrence13.2 (COOC13.2), VOSviewer, CiteSpace, and HistCite for analysis. Results A total of 1736 related kinds of papers were included, and the number of papers presented an overall increasing trend. The country/region with the most publications is the USA, the institution is the Harvard Medical School, the author is Yehuda Shoenfeld from Israel, and the journal is Frontiers in Immunology. Research hotspots include immune responses (such as cytokines storm), multisystem ADs (such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis), treatment modalities (such as hydroxychloroquine, rituximab), vaccination and autoimmune mechanisms (such as autoantibodies, molecular mimicry). The future research direction may be the mechanisms and treatment ideas of the association between ADs and COVID-19 (such as NF-κB, hyperinflammation, antiphospholipid antibodies, neutrophil extracellular traps, granulocyte-macrophage colony-stimulating factor), other cross-diseases of COVID-19 and ADs (such as inflammatory bowel disease, chronic mucocutaneous candidiasis, acute respiratory distress syndrome). Conclusion The growth rate of publications regarding ADs and COVID-19 has risen sharply. Our research results can help researchers grasp the current status of ADs and COVID-19 research and find new research directions in the future.

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Pediatric Systemic Lupus Erythematous in COVID-19 Era

Cited by 7 publications

References 66 publications

Celiac disease - a pluripathological model in pediatric practice

Celiac disease - a pluripathological model in pediatric practice

Clinical Features of COVID-19 in Pediatric Rheumatic Diseases: 2020–2022 Survey of the Pediatric Rheumatology Association of Japan

Knowledge mapping of COVID-19 and autoimmune diseases: a visual and bibliometric analysis

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