Pediatric Spine Tumors with Spinal Cord Compromise

Conrad, Ernest U.; Olszewski, Albert D.; Berger, Mitchell S.; Powell, Eli; Bruckner, James D.

doi:10.1097/01241398-199207000-00007

Cited by 30 publications

(29 citation statements)

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“…The association between the primary tumor location and the prevalence of spinal deformity is disputed. Two studies found more spinal deformity with thoracic located tumors, while two other studies did not found such an association …”

Section: Resultsmentioning

confidence: 92%

“…to 100%. 1,10,34,35,41,46,48,50,51 The severity of the motor deficit at diagnosis was reported in 15 studies. 1,8,10,11,34,37,41,42,[46][47][48][49][50][51]53 The symptom to diagnosis interval, reported as a mean or median, showed considerable variation, ranging from 3 days to 2 months (median 25.5 days).…”

Section: Characteristics Of Nbl With Intraspinal Extensionmentioning

confidence: 99%

“…1,10,34,35,41,46,48,50,51 The severity of the motor deficit at diagnosis was reported in 15 studies. 1,8,10,11,34,37,41,42,[46][47][48][49][50][51]53 The symptom to diagnosis interval, reported as a mean or median, showed considerable variation, ranging from 3 days to 2 months (median 25.5 days). 1,8,10,11,[33][34][35]37,[46][47][48][49][50][51]53 Nineteen studies reported on the prevalence of neurological motor deficit at the end of follow-up, which ranged from 17 to 69% (median 50%).…”

Section: Characteristics Of Nbl With Intraspinal Extensionmentioning

confidence: 99%

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Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

Kraal

Blom

Noesel

et al. 2017

Pediatric Blood & Cancer

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We performed a systematic review to define the long-term health problems and optimal treatment strategy for patients with neuroblastoma with intraspinal extension. Of 685 identified studies, 28 were included in this review. The burden of long-term health problems is high; a median of 50% of patients suffered from neurological motor deficit, 34% from sphincter dysfunction, and 30% from spinal deformity. The currently available literature remains suboptimal as a guide for treatment of NBL with intraspinal extension. More well-designed, prospective studies are needed to determine the optimal treatment strategy.

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Section: Resultsmentioning

confidence: 92%

Section: Characteristics Of Nbl With Intraspinal Extensionmentioning

confidence: 99%

Section: Characteristics Of Nbl With Intraspinal Extensionmentioning

confidence: 99%

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Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

Kraal

Blom

Noesel

et al. 2017

Pediatric Blood & Cancer

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“…The use of immediate chemotherapy is controversial but can be of benefit in chemosensitive pediatric round small cell tumors and sarcomas [17], Mones et al [ 18] and Hayes et al [ 19] reported an excellent outcome in a PST population with spinal cord compression who had been initially treated with chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Neurologic Complications in Pediatric Solid Tumors

Arush

Stein²,

Perez-Nachum

et al. 1995

Oncology

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The cases of 61 children, consecutively diagnosed during 1986–1990 as having malignant solid tumors (but excluding those with brain tumors and lympho-proliferative diseases), were reviewed. Neurologic complications occurred in 19 (31 %), most often in association with neuroblastomas and sarcomas. Complications observed in order of frequency were: brain metastases in 6 children, spinal cord compression in 5, peripheral or cranial neuropathies in 4, and seizures in the remaining 4. Early recognition of neurologic compromise and rapid initiation of treatment are mandatory in order to prevent permanent disability.

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“…In quest'ultimo subset di pazienti, gli istotipi più frequenti sono tipicamente dotati di altissima chemiosensibilità (tumore di Wilms, sarcoma di Ewing, neuroblastoma, linfomi non Hodgkin, rabdomiosarcoma) ed inoltre vi è la prioritaria necessità clinica di evitare l'impiego della radioterapia, anch'essa estremamente efficace ma gravata da sequele inaccettabili per un organismo in accrescimento. Esiste una vasta esperienza di letteratura attestante l'estrema efficacia della chemioterapia, anche quando impiegata da sola, nel risolvere senza sequele significative le sindromi da compressione midollare nel paziente oncologico pediatrico 12,26,29,37,60,62 .…”

Section: Inquadramento Terapeuticounclassified

I tumori del rachide

Ferraú¹,

Antonelli²

2002

Rivista di Neuroradiologia

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RIASSUNTO -Il sistema scheletrico rappresenta nei tumori solidi la terza sede metastatica in ordine di frequenza, dopo fegato e polmoni. Di tutti i segmenti ossei, il rachide risulta essere quello maggiormente interessato. Dal punto di vista prognostico, il coinvolgimento osseo consente sopravvivenze relativamente più lunghe, ma è in grado di condizionare la qualità di vita pesantemente. L'integrazione terapeutica multispecialistica è indispensabile per una corretta valutazione diagnostica e terapeutica. Il trattamento comprende il controllo della malattia neoplastica di base e la terapia delle manifestazioni conseguenti alle metastasi ossee: compressione midollare, dolore, ipercalcemia, complicanze internistiche. Il trattamento oncologico specifico dipende fondamentalmente dallo stadio di malattia, dall'eventuale concomitante coinvolgimento viscerale, dalla ormonodipendenza e dalla chemiosensibilità della patologia neoplastica di base. SUMMARY -The skeleton is the third most common site of metastases after the liver and lung. Of all bone segments, the spine is the most frequently affected. In terms of prognosis, patients with bone involvement have a relatively long survival rate, but a poor quality of life. A multidisciplinary approach is essential for accurate diagnostic and therapeutic assessment. Treatment includes control of the primary tumour and therapy for the signs and symptoms of bone metastases: cord compression, pain, hypercalcaemia and internal complications.Specific cancer treatment basically depends on the disease stage, possible concomitant visceral involvement, hormone dependence and chemosensitivity of the primary tumour.

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Pediatric Spine Tumors with Spinal Cord Compromise

Cited by 30 publications

References 0 publications

Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

Neurologic Complications in Pediatric Solid Tumors

I tumori del rachide

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