Pediatric Solid Tumors of Infancy: An Overview

Allen‐Rhoades, Wendy; Whittle, Sarah Burkhead; Rainusso, Nino

doi:10.1542/pir.2017-0057

Cited by 50 publications

(54 citation statements)

References 6 publications

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“…These cells type found in retinoblastoma, neuroblastoma, Ewing's sarcoma, rhabdomyosarcoma, hepatoblastoma, non-Hodgkin's lymphoma, primitive neuroectodermal tumors (PNET) and Wilm's tumor, while a specific type small blue round cell tumor more emphasis on neuroblastoma, rhabdomyosarcoma, non-Hodgkin's lymphoma, Ewing's sarcoma, primitive neuro ectodermal tumor (PNET) and Wilm's tumor. 5 Retinoblastoma is the most common pediatric intraocular tumor with an incidence of 1:15.000 to 1:18.000 births and the onset of the symptoms mostly appears at the age of 2 years old. Most retinoblastomas occur unilateral (60%) but can also bilaterally, where 0,5% unilateral retinoblastoma develops into trilateral retinoblastoma with median time of transformation is 21 months.…”

Section: Discussionmentioning

confidence: 99%

Retinoblastoma or Neuroblastoma: an imaging polemic issues

Giri¹,

Anandasari²,

Margiani³

et al. 2020

Int J Res Med Sci

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Both retinoblastoma and neuroblastoma are common childhood malignancy, which classified as malignant round cell tumors, but have different diagnostic, therapeutic, prognostic criteria and metastases pattern. A case was evaluated with an imaging examination resembled neuroblastoma metastatic process but was diagnosed as retinoblastoma. A 2-years-old boy came with chief complaint swollen right eye. Prior history was itchy and increasingly swollen right eye, decreased vision and gradually increases pain. There was no sign of leukocoria. Histopathology result confirmed malignant round cell tumor. Axial contrast-enhanced head CT image, depicted right intra orbital mass, 1.9x2x1.8 cm in size as well as mass in the right frontoparietal region which pushed the right frontal lobe, accompanied by erosion and periosteal reaction in the surrounding bone with meningeal and soft tissue involvement. In this case, although there was no leukocoria as the diagnostic criteria for retinoblastoma, we still found intraorbital and pineal body mass also malignancies in several long bones. The diagnosis of trilateral retinoblastoma has been established followed by retinoblastoma’s chemotherapy regiment, which showed good response, in spite of discrepancy in retinoblastoma’s metastases pattern. A complete systemic workup includes CT scan examination needs to be perform in order to help the clinicians determine the diagnosis of orbital mass with malignant round cell histopathology.

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Section: Discussionmentioning

confidence: 99%

Retinoblastoma or Neuroblastoma: an imaging polemic issues

Giri¹,

Anandasari²,

Margiani³

et al. 2020

Int J Res Med Sci

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“…Around 40% of all pediatric cancers account to solid tumors (Table 2) [28]. Many of them are so-called embryonal tumors, a heterogeneous group of cancers that exhibit in common a developmental origin from undifferentiated cells, and present histological features that resemble the forming fetus tissues [29].…”

Section: Embryonal Solid Tumorsmentioning

confidence: 99%

“…The most common types of embryonal solid tumors are neuroblastoma, some central nervous system tumors (medulloblastoma, ependymoma, and rhabdoid tumor), Wilms tumor, retinoblastoma, hepatoblastoma, clear cell sarcoma of the kidney, primitive neuroectodermic tumor (PNET)/Ewing sarcoma, and few other tumors [28]. There are a few studies based on metabolomics by NMR obtained from some of these cancer types, which are summarized in Table 3 and briefly commented in the following sections.…”

Section: Embryonal Solid Tumorsmentioning

confidence: 99%

Insights into the Chemical Biology of Childhood Embryonal Solid Tumors by NMR-Based Metabolomics

et al. 2019

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Most childhood cancers occur as isolated cases and show very different biological behavior when compared with cancers in adults. There are some solid tumors that occur almost exclusively in children among which stand out the embryonal solid tumors. These cancers main types are neuroblastoma, nephroblastoma (Wilms tumors), retinoblastoma and hepatoblastomas and tumors of the central nervous system (CNS). Embryonal solid tumors represent a heterogeneous group of cancers supposedly derived from undifferentiated cells, with histological features that resemble tissues of origin during embryogenesis. This key observation suggests that tumorigenesis might begin during early fetal or child life due to the errors in growth or pathways differentiation. There are not many literature data on genomic, transcriptomic, epigenetic, proteomic, or metabolomic differences in these types of cancers when compared to the omics- used in adult cancer research. Still, metabolomics by nuclear magnetic resonance (NMR) in childhood embryonal solid tumors research can contribute greatly to understand better metabolic pathways alterations and biology of the embryonal solid tumors and potential to be used in clinical applications. Different types of samples, such as tissues, cells, biofluids, mostly blood plasma and serum, can be analyzed by NMR to detect and identify cancer metabolic signatures and validated biomarkers using enlarged group of samples. The literature search for biomarkers points to around 20–30 compounds that could be associated with pediatric cancer as well as metastasis.

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“…Moleküler açıdan embriyonel RMS'larda karakteristik translokasyon tanımlanmamıştır, ancak alveolar RMS'ların %85'inde iki translokasyondan biri bulu- nur: t(2;13) (q35;q14) veya t(1;13) (p36;q14). Bu translokasyonlar sırasıyla PAX3-FOXO1 ve PAX7-FOXO1 füzyon genlerinin oluşumuna neden olur (7,9) .…”

Section: Rabdomyosarkomunclassified

“…Kanserin yaşlara göre dağılımını incelediğimizde, ilk bir yaşta daha çok spesifik alanlarda-organlarda-lokalize nöroblastom, retinoblastom ve nefroblastomun ön planda olduğu embriyonel primitif tümörler, 1-4 yaş arasında lösemiler ve 5-14 yaş arasında lösemi/lenfoma ve santral sinir sistemi tümörlerinin vakaların büyük çoğunluğunu oluşturduğu görülür. Özetle çocukluk yaş grubuna özgü "primitif" tümörler, fetal yaşamdaki her üç germ yaprağından -mesoderm, -endoderm, -ektodermdenköken alır ve ciddi tanı tuzaklarına sahiptir (4)(5)(6)(7) .…”

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Childhood Malign Solid Soft Tissue Sarcomas; Diagnostic, Histopathological and Molecular Approach

Yıldırım¹,

Yıldırım²,

Diniz³

et al. 2019

BUCH

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Childhood soft tissue sarcomas are heterogenous and be quite varied in apperance. Especially, these neoplasms known as "small round cell tumor" group, with their hyperchromatic nuclei and monotonous small and limited cytoplasm. These neoplasms share many similar histomorphological and immunophenotypic characteristics Also these lesions may often demonstrate similar clinical and radiological characteristics but have diverse prognoses. The purpose of this article is to review clinical, histologic, immunohistochemical features and molecular features of soft tissue sarcomas and discuss the differential diagnosis of these tumours.

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Pediatric Solid Tumors of Infancy: An Overview

Cited by 50 publications

References 6 publications

Retinoblastoma or Neuroblastoma: an imaging polemic issues

Retinoblastoma or Neuroblastoma: an imaging polemic issues

Insights into the Chemical Biology of Childhood Embryonal Solid Tumors by NMR-Based Metabolomics

Childhood Malign Solid Soft Tissue Sarcomas; Diagnostic, Histopathological and Molecular Approach

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