Pediatric Skin Tumors

Wyatt, Angela J.; Hansen, Ronald C.

doi:10.1016/s0031-3955(05)70250-9

Cited by 27 publications

(12 citation statements)

References 100 publications

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“…[13][14][15][16][17][18][19] GCMN are firmly associated with an increased risk of cutaneous and extracutaneous melanoma, but the magnitude of this association is still discussed. 20,21 Large studies found that melanoma developed within 2.5%-2.9% of GCMN .20 cm in diameter and 3.1% of GCMN .40 cm in diameter, whereas small and median CMN are not related to a higher risk of melanoma.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Melanoma in Association With a Giant Congenital Melanocytic Nevus in an Adult

Machan

Molina-Ruiz

Fernández-Aceñero³

et al. 2015

The American Journal of Dermatopathology

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Giant congenital melanocytic nevi (GCMNs) represent a distress to patients for 2 reasons: one is disfigurement, and the other is the increased risk of developing secondary melanocytic tumors, such as benign proliferative nodules (BPNs) and malignant melanoma (MM). BPN present as a rapid growth nodule arising within a congenital melanocytic nevus (CMN) that often ulcerates, occurs in children younger than 2 years of age. BPNs arising within a CMN are exceedingly rare after childhood, and very few cases have been described in adults. Despite the worrisome clinical and histologic findings of BPN, most laboratory investigations seem to support their benignity. The distinction between MM and BPN is extremely important, but the histopathology of BPN of GCMN can be a challenge to differentiate from MM. In the recent years, molecular tests that investigate DNA copy number alterations such as fluorescence in situ hybridization and comparative genomic hybridization have shown promise to help guide the diagnosis of ambiguous melanocytic proliferations arising within CMNs. We report the case of a 22-year-old woman with a nodule arising in a GCMN and with an axillary mass suggesting a nodal metastasis of melanoma, and discuss the unusual clinical, histopathologic, and molecular findings that make this case particularly interesting.

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Section: Discussionmentioning

confidence: 99%

Metastatic Melanoma in Association With a Giant Congenital Melanocytic Nevus in an Adult

Machan

Molina-Ruiz

Fernández-Aceñero³

et al. 2015

The American Journal of Dermatopathology

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“…Overlying skin changes, such as a purplish discoloration similar to a hemangioma, may be present. Ulceration and skin atrophy have also been described [9].…”

Section: Discussionmentioning

confidence: 99%

“…The systemic evaluation for multicentric myofibromatosis is advised, with overall mortality being 15-20% [1]. There are microscopic similarities with malignant lesions; however, the pathologist must exercise great care in the diagnosis [6,8,9]. Chemotherapy or radiation has been seldom used, except for a few cases with recurrence or non-respectable lesion [10].…”

Section: Discussionmentioning

confidence: 99%

Congenital scalp myofibroma: A case report

Abujarir

Salama

Al-Sulaiti

et al. 2011

Journal of Neonatal-Perinatal Medicine

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Myofibroma tumors are uncommon benign neoplasms, affecting mainly the early pediatric age group. Infantile myofibromas consist of benign nodules in the skin, muscle, or bone .Less often, they can occur in the lung, heart, gastrointestinal tract, or orbit. Infantile myofibromas exhibit growth in the immediate perinatal period that may continue for the first few months of life, reaching a size approaching several centimeters in diameter. Because this tumor grows rapidly during infancy, capillary hemangioma of the scalp or malignant neoplasia is often suspected. We examine a case of solitary infantile myofibroma in a newborn's scalp, which presented a diagnostic challenge.

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“…The tumor can result in other skin manifestations representing either true skin metastasis or secondary lesions due to an underlying hematologic disorder. True cutaneous metastatic lesions of neuroblastoma are papules or nodules that are firm, bluegray, and nontender [9]. The lesions are characterized by a distinctive central blanching phenomenon, which is a response to rubbing with central blanching and a surrounding erythematous halo that persists for 30-60 min [10].…”

Section: Discussionmentioning

confidence: 99%

Sudden death due to adrenal neuroblastoma: child abuse mimic?

Park

Prahlow

2010

Forensic Sci Med Pathol

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Neuroblastoma is one of the most common malignancies in children. It is a tumor that can clinically present with varied symptoms that can mimic other entities, including child abuse. It is important that forensic pathologists are aware of the diseases that can masquerade as child abuse. A case of sudden, unexpected death in a 2-year-old due to previously undiagnosed neuroblastoma is presented. At initial presentation of the child in the emergency department, child abuse was considered as a possible explanation for the sudden demise. Death occurred before a full clinical workup could be completed and an autopsy was performed which unveiled the cause of death.

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Pediatric Skin Tumors

Cited by 27 publications

References 100 publications

Metastatic Melanoma in Association With a Giant Congenital Melanocytic Nevus in an Adult

Metastatic Melanoma in Association With a Giant Congenital Melanocytic Nevus in an Adult

Congenital scalp myofibroma: A case report

Sudden death due to adrenal neuroblastoma: child abuse mimic?

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