Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model with Septic Shock Phenotype

Murphy, Ryan Anne

doi:10.1016/j.jemermed.2016.12.022

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2020

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“…In recent years, The Pediatric Sepsis Biomarker Risk Model (PERSEVERE, PERSEVERE II, and PERSEVERE-XP) biomarker panels based on patient genome studies have been developed to identify the risk of death in septic shock in children. PERSEVERE biomarkers are generally associated with inflammation and cellular damage, which makes it highly likely to identify the risk of deterioration in a particular child with septic shock [50], [51], [52].…”

Section: Sirsmentioning

confidence: 99%

Modern Diagnostics of Sepsis and Septic Shock in Children

Bulatova

Maltabarova

Zhumabayev

et al. 2020

Open Access Maced J Med Sci

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Sepsis is still one of the leading causes of child mortality worldwide, despite advances in its diagnosis and treatment. Difficulties in recognizing the transition of a localized infectious-inflammatory process to a generalized one lead to a belated diagnosis and the beginning of therapy. Meanwhile, the earlier treatment is started, the higher the patients’ chances of life. Early diagnosis of sepsis, which corresponds to modern ideas about this condition, is one of the main tasks for both scientists and practitioners. The aim of this review is to study modern recommendations for the diagnosis of sepsis and septic shock in children. The article reflects the epidemiology, etiological features, modern definitions, and methods of diagnosis of pediatric sepsis.

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Section: Sirsmentioning

confidence: 99%