Pediatric Research and COVID-19: the changed landscape

Molloy, Eleanor J.; Bearer, C. B.

doi:10.1038/s41390-021-01857-0

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…The few studies published showed COVID-19 resulted in widespread use of telemedicine and the internet to improve recruitment, conduct consent and data collection as well as unprecedented levels of international collaboration. 14 , 15 …”

Section: Discussionmentioning

confidence: 99%

Impact of early COVID-19-related challenges on pediatric researchers: an exploratory analysis

2023

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Section: Discussionmentioning

confidence: 99%

Impact of early COVID-19-related challenges on pediatric researchers: an exploratory analysis

2023

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COVID-19 Virus Structural Details: Optical and Electrochemical Detection

et al. 2023

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Multisystem inflammatory syndrome in children (MIS-C) and neonates (MIS-N) associated with COVID-19: optimizing definition and management

et al. 2022

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During the SARS-CoV-2-associated infection (COVID-19), pandemic initial reports suggested relative sparing of children inversely related to their age. Children and neonates have a decreased incidence of SARS-CoV-2 infection, and if infected they manifested a less severe phenotype, in part due to enhanced innate immune response. However, a multisystem inflammatory syndrome in children (MIS-C) or paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 emerged involving coronary artery aneurysms, cardiac dysfunction, and multiorgan inflammatory manifestations. MIS-C has many similarities to Kawasaki disease and other inflammatory conditions and may fit within a spectrum of inflammatory conditions based on immunological results. More recently neonates born to mothers with SARS-CoV-2 infection during pregnancy demonstrated evidence of a multisystem inflammatory syndrome with raised inflammatory markers and multiorgan, especially cardiac dysfunction that has been described as multisystem inflammatory syndrome in neonates (MIS-N). However, there is a variation in definitions and management algorithms for MIS-C and MIS-N. Further understanding of baseline immunological responses to allow stratification of patient groups and accurate diagnosis will aid prognostication, and inform optimal immunomodulatory therapies. Impact Multisystem inflammatory system in children and neonates (MIS-C and MIS-N) post COVID require an internationally recognized consensus definition and international datasets to improve management and plan future clinical trials. This review incorporates the latest review of pathophysiology, clinical information, and management of MIS-C and MIS-N. Further understanding of the pathophysiology of MIS-C and MIS-N will allow future targeted therapies to prevent and limit clinical sequelae.

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Pediatric Research and COVID-19: the changed landscape

Cited by 4 publications

References 20 publications

Impact of early COVID-19-related challenges on pediatric researchers: an exploratory analysis

Impact of early COVID-19-related challenges on pediatric researchers: an exploratory analysis

COVID-19 Virus Structural Details: Optical and Electrochemical Detection

Multisystem inflammatory syndrome in children (MIS-C) and neonates (MIS-N) associated with COVID-19: optimizing definition and management

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