Pediatric renal transplantation: Single center experience

Mır, Sevgı; Erdoğan, Hakan; Serdaroğlu, Erkin; Kabasakal, Caner; Hoşçoşkun, Cüneyt

doi:10.1111/j.1399-3046.2005.00249.x

Cited by 20 publications

(15 citation statements)

References 27 publications

(31 reference statements)

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“…Overall 5-year patient survival varies between 70% and 100% at 5 years [1, 5–7, 9, 12, 13, 16, 18, 20–26], 75% to 95% at 10 years [1, 7, 9, 12, 18, 21, 23–26], 83% to 94% at 15 years [1, 27], 54% to 86% at 20 years [1, 5, 7] and there is one report of 81% 25-year patient survival [6]. …”

Section: Introductionmentioning

confidence: 99%

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Long-term outcome after renal transplantation in childhood

Rees

2009

Pediatr Nephrol

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and learning objectives:The purpose of this article is to review:1. Factors influencing long-term outcome data after transplantation 2. Patient survival overall, the effect of recipient age and donor type, causes of death, comparison of mortality after transplantation with that on dialysis, and effect of pre-emptive transplantation and race 3. Transplant survival overall, and the effect of recipient and donor age, donor type, pre-emptive transplantation, recurrent diseases, human leukocyte antigen (HLA) matching, immunosuppression, concordance, hypertension, bladder dynamics and type of donor nephrectomy 4. Final height and obesity 5. Psycho-social outcome

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Section: Introductionmentioning

confidence: 99%

“…Overall 5-year transplant survival varies between 44% to 95% [1, 7–9, 12, 14, 18, 21, 23–26, 30] at 5 years, 23%–95% at 10 years [1, 7–9, 12, 21, 23–26, 30], 35% at 15 years [8] and 21–36% at 20 years [1, 6, 8]. …”

Section: Introductionmentioning

confidence: 99%

Long-term outcome after renal transplantation in childhood

Rees

2009

Pediatr Nephrol

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“…Transplantation is the treatment of choice in most of the children with end-stage renal disease (ESRD) [1].…”

Section: Introductionmentioning

confidence: 99%

Pediatric live-donor kidney transplantation in Mansoura Urology & Nephrology Center: a 28-year perspective

et al. 2006

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Our objective was to evaluate our overall experience in pediatric renal transplantation. Between March 1976 and March 2004, 1,600 live-donor kidney transplantations were carried out in our center; 216 of the patients were 18 years old or younger (mean age 12.9 years). There were 136 male patients and 80 female patients. The commonest causes of end-stage renal disease (ESRD) were renal dysplasia (22%), nephrotic syndrome (20%), hereditary nephritis (16%), and obstructive uropathy (16%). Of the donors, 94% were one-haplotype matched and the rest were identical. Pre-emptive transplantation was performed in 51 (23%) patients. Triple-therapy immunosuppression (prednisone + cyclosporine + azathioprine) was used in 78.2% of transplants. Rejection-free recipients constituted 47.7%. Hypertension (62%) was the commonest complication. A substantial proportion of patients (48%) were short, with height standard deviation score (SDS) less than -1.88. The overall infection rate was high, and the majority (53%) of infections were bacterial. The graft survival at 1 year, 5 years and 10 years were 93.4%, 73.3% and 48.2%, respectively, while the patients' survival at 1, 5 and 10 years were 97.6%, 87.8% and 75.3%, respectively. Despite long-term success results of pediatric renal transplantation in a developing country, there is a risk of significant morbidity.

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“…Growth and development are maximized, and long-term results from several centers are excellent [1]. However many pediatric renal transplantation (RTx) populations have some sort of chronic renal failure (CRF).…”

Section: Introductionmentioning

confidence: 99%

Complications of pediatric live-donor kidney transplantation: a single center’s experience in Egypt

2008

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Our objective was to study the complications of chronic renal failure (CRF) among pediatric live-donor kidney transplant recipients. Between March 1976 and December 2005, 1,785 live-donor kidney transplantations were carried out at our center. Of the recipients, 292 were 20 years old or younger (mean age 12.8 years, ranging from 4 years to 20 years). Clinical and laboratory parameters of these 292 patients were analyzed retrospectively. They were 182 boys and 110 girls. Patients who had received transplants before 1988 were treated with prednisolone and azathioprine as combined therapy. From 1988 to 1998, a triple regimen comprising prednisolone, azathioprine and cyclosporine A (CsA) was administered. Tacrolimus and mycophenolate mofetil (MMF) were introduced as primary therapy in 1998. Growth, anemia, infections, and surgical, cardiac, neurologic, bone and other medical complications were assessed. Triple-drug immunosuppression (prednisone + CsA + azathioprine) was used in 68.2% of transplants. Acute rejection rate was 47.6%; chronic rejection rate was 31%. Hypertension (62%) was the commonest complication. Anemia was diagnosed in 61%. A substantial proportion of patients (48%) were short, with height standard deviation scores (SDSs) of less than -1.88. The overall infection rate was high, and the majority (54%) was bacterial. Malignancy was diagnosed in eight (3%) patients. The incidence of urological complications was 14%, and that of vascular complications was 1%. Cardiac complications included left ventricular hypertrophy (LVH) in 47.9% of patients, left atrial enlargement (31.5%) and left ventricular dilatation and systolic dysfunction (13.7% for each). Neuropathic changes were found in 19% of our cases, with the distal muscles of lower limbs more affected. Other complications included avascular bone necrosis in 8% (all of them in the hip joint) and bone loss in 60% of patients. We concluded that, despite the long-term success of pediatric renal transplantation in a developing country, there is a risk of significant morbidity.

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Pediatric renal transplantation: Single center experience

Cited by 20 publications

References 27 publications

Long-term outcome after renal transplantation in childhood

Long-term outcome after renal transplantation in childhood

Pediatric live-donor kidney transplantation in Mansoura Urology & Nephrology Center: a 28-year perspective

Complications of pediatric live-donor kidney transplantation: a single center’s experience in Egypt

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