Pediatric Reference Ranges for Osteocalcin Measured by the Immulite Analyzer

Seydewitz, H. H.; Henschen, M.; Kühnel, Werner; Brandis, M.

doi:10.1515/cclm.2001.159

Cited by 14 publications

(15 citation statements)

References 4 publications

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“…The serum concentrations of markers for bone turnover (Table 3) are comparable with the levels of markers of bone turnover observed in another studies conducted on prepubertal, European boys (Seydewitz et al, 2001;Kanbur et al, 2005). At baseline, the markers for bone turnover were not significantly different between the groups.…”

Section: Serum Biochemical Measurementssupporting

confidence: 82%

High intake of milk, but not meat, decreases bone turnover in prepubertal boys after 7 days

et al. 2007

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Objective: To compare the short-term effect of a high milk and a high meat intake, identical in protein amount, on bone turnover during prepuberty. Setting: A University Department. Design and Subjects: From 28, randomly recruited, 8-year-old boys, first 14 were assigned to the milk group and next 14 to the meat group. In each group, 12 boys finished the dietary intervention. Intervention: Milk (1.5 l/day) and meat (250 g/d), both containing B53 g of protein, were given together with the habitual diet for 7 days. At baseline and dayÀ7, serum osteocalcin (s-OC), bone-specific alkaline phosphatase (s-BAP) and C-terminal telopeptides of type I collagen (s-CTX) were measured (immunoassay) and dietary intake was estimated (a 3-day weighted food record). Results: Baseline s-OC, s-BAP and s-CTX were not significantly different between the groups. After 7 days, the average protein intake increased in both groups by 47.5 g; the milk group had higher (Po0.0001) calcium intake; s-OC and s-CTX decreased (Pp0.04) in the milk group (À30.9%; À18.7%, respectively) compared with the meat group ( þ 6.4%; À1.0%, respectively) and s-BAP decreased (P ¼ 0.06) both in the milk (À3.9%) and the meat group (À7.5%). Conclusions: At the equal protein intake, milk, but not meat, decreased bone turnover in prepubertal boys after 7 days. This effect was probably due to some milk-derived compounds, rather than to the total protein intake. Future studies should elucidate the mechanism(s) of milk-related decline of bone turnover and its relevance for peak bone mass during growth. Sponsorship: University PhD scholarships.

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Section: Serum Biochemical Measurementssupporting

confidence: 82%

High intake of milk, but not meat, decreases bone turnover in prepubertal boys after 7 days

et al. 2007

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“…Positive relationships between bone-specific formation and resorption markers are expected, and reflect the nature of bone turnover as a tightly regulated dynamic mechanism of formation and resorption [6]. Our absence of correlation between tALP and OC corroborates previous findings [37] but contradicts more recent results that showed direct correlations among formation markers [13, 38]. The recent hypothesis that OC is a marker of bone turnover as a whole, reflecting not only bone formation but also resorption, may explain its less consistent associations with other formation markers [39].…”

Section: Discussionsupporting

confidence: 91%

Bone formation and resorption markers at 7 years of age: Relations with growth and bone mineralization

et al. 2019

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Purpose We aimed to describe bone formation and resorption markers in generally healthy prepubertal children using total alkaline phosphatase (tALP), osteocalcin (OC) and β-isomerized C-terminal telopeptides of type I collagen (β-CTx) serum concentrations and to estimate markers’ correlations with anthropometric growth (height, weight, body mass index and trajectories of weight gain) as well as bone mineral content (BMC) and areal density (aBMD). Methods We assessed 395 7-year-old children from the Generation XXI cohort with tALP, OC and β-CTx concentrations determined from a fasting venous blood sample and BMC/aBMD measured by dual-energy X-ray absorptiometry. Gender-specific reference intervals for tALP, OC and β-CTx in 7-year-old children were established by calculating the 2.5 th and 97.5 th percentiles. Pearson and partial correlation coefficients (controlling for sex, age, body size and season) between bone markers and growth measures were computed. Results tALP increased with height (r partial controlled for sex = 0.26, 95%CI: 0.17, 0.35), was higher in overweight than in healthy weight children, and in children who gained weight above average during infancy. No correlations were found between OC or β-CTx and growth. In girls, OC was slightly correlated with subtotal BMC (r partial = 0.22, 95%CI: 0.08, 0.35), subtotal aBMD (r partial = 0.20, 95%CI: 0.06, 0.33) and lumbar spine aBMD (r partial = 0.23, 95%CI: 0.09, 0.36). tALP and β-CTx were not correlated with any of the DXA-derived bone measures. Conclusion This study contributed to the description of bone turnover at 7 years of age and suggested that bone metabolism markers measured in a single point in time have limited ability to describe anthropometric growth and overall bone status in generally healthy prepubertal children.

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“…Osteocalcin synthesis is induced in osteoblasts by 1,25‐dihydroxyvitamin D 3 and its level is higher during childhood with a peak during puberty. Although comparison of osteocalcin values across studies is difficult due to different assay methods 27, the median value for the patients between 10–12 years observed in this study (12.2 ng/ml, range 2.2–17.9) is significantly lower than previously reported in healthy children using chemiluminiscent immunoassay (median prepubertal osteocalcin level 34.4 ng/ml, range 17.1–66.7) 27. The time of obtaining blood sample was not standardized in either of these studies, which could increase the variability in the results from diurnal variation in the serum osteocalcin levels.…”

Section: Discussionmentioning

confidence: 99%