Pediatric Reference Intervals for Several Biochemical Analytes in School Children in Central Taiwan

Lai, Dong Shang; Chen, Shivan Chih; Chang, Yih Hsin; Chen, Chien-Yi; Lin, Jye-Bin; Lin, Yi; Yang, Shun Fa; Yang, Cuiping; Chen, Wen Kang; Ding, Lin

doi:10.1016/s0929-6646(10)60009-5

Cited by 21 publications

(13 citation statements)

References 19 publications

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“…For example, the study by Gomez et al found patterns in creatinine, total bilirubin, and LDH con-centrations that were similar to those of our study when they were plotted over time and that reflected the underlying physiological changes that occur throughout childhood (35 ). Similarly, the trends in our data for alanine aminotransferase and creatinine showed similarities to the data presented by Lai et al, who studied a population that included 5000 healthy participants from 3 years of age to adult (34 ). The CALIPER reference intervals obtained for creatinine (enzymatic) in the present study were also closely similar to the ageadjusted reference intervals reported by Ceriotti et al (26 ), likely owing to the use of isotope-dilution mass spectroscopy-standardized methods in both studies.…”

Section: Discussionsupporting

confidence: 88%

Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children

et al. 2012

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BACKGROUND:Pediatric healthcare is critically dependent on the availability of accurate and precise laboratory biomarkers of pediatric disease, and on the availability of reference intervals to allow appropriate clinical interpretation. The development and growth of children profoundly influence normal circulating concentrations of biochemical markers and thus the respective reference intervals. There are currently substantial gaps in our knowledge of the influences of age, sex, and ethnicity on reference intervals. We report a comprehensive covariate-stratified reference interval database established from a healthy, nonhospitalized, and multiethnic pediatric population.

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Section: Discussionsupporting

confidence: 88%

Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children

et al. 2012

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“…This finding is consistent with some previous studies in Iranian children and adolescents (5, 14, 17, 26). In a study in Taiwan, the 2.5th-97.5th percentiles of ALT in children are reported 8-38 IU/L with significantly higher levels in boys than in girls (13). Likewise, in Australian adolescents both enzyme values were higher in boys than in girls (12).…”

Section: Discussionmentioning

confidence: 99%

First National Report on Aminotransaminases` Percentiles in Children of the Middle East and North Africa (MENA): the CASPIAN-III Study

et al. 2012

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BackgroundBy the current global obesogenic environment, non-alcoholic fatty liver disease is becoming an important health problem in the pediatric age group.ObjectivesThis study aimed to determine the first age-and gender-specific percentiles and upper limit normal limit (ULN) of alanine aminotransaminase (ALT) and aspartate aminotransaminase (AST) among a nationally-representative sample of children and adolescents in the Middle East and North Africa (MENA). The second objective was to determine the linear association of obesity indexes and age with serum ALT and AST levels.Patients and MethodsThis nationwide study was conducted among a representative sample of 4078 students aged 10-18 years, who were selected by multistage random cluster sampling from 27 provinces of Iran. ALT and AST were measured on fresh sera. Body mass index (BMI) was calculated as an index of generalized obesity, and waist- to- height ratio (WHtR) as an index of abdominal obesity. The age- and gender-specific percentiles of ALT and AST were constructed, and the 95th percentile of each enzyme was considered as the ULN. Gender-specific linear regression analysis was employed to examine the association of BMI or WHtR with the levels of ALT and AST.ResultsData of ALT and AST were available for 4078 (2038 girls) and 4150 (2061 girls),respectively. Participants had a mean (SD) age of 14.71 (2.41).The ULN of ALT for boys, girls,and the total individuals were 36.00; 38.00; and, 37.00 U/L, respectively. In both genders, ALT and AST had linear association with age. The association with BMI was significant for ALT in both genders and for AST only in boys, the association of ALT with WHtR was significant in both genders; the corresponding figures were not significant for AST.ConclusionsThe findings of the current study confirmed the current ULN value of 40 U/L commonly used for the pediatric age group. The linear association of indexes for generalized and abdominal obesity with ALT underscores the importance of timely prevention and control of childhood obesity.

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“…Several papers containing age-specific reference values of serum urea have been published [62,63]. Unlike creatinine, serum urea levels are not clearly age-related but rather reflect fluid and protein intake and metabolism.…”

Section: Reference Values In Childrenmentioning

confidence: 99%

Endogenous markers for kidney function in children: a review

Bakker

Gemke

Bökenkamp

2018

Critical Reviews in Clinical Laboratory Sciences

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Although glomerular filtration rate (GFR) in children can be measured using a gold-standard technique following injection of an exogenous marker, this invasive and cumbersome technique is not widely available and GFR is commonly estimated using serum levels of endogenous markers. Creatinine, urea, cystatin C, beta-trace protein, and beta-2 microglobulin are well-established endogenous markers of kidney function. These markers differ in site of production and effects of diet and medication, as well as renal-tubular handling and extra-renal elimination. For each marker, different methods are available for measurement. Importantly, the measurements of creatinine and cystatin C have recently been standardized with the introduction of international reference standards. In order to allow estimation of GFR from serum marker concentrations, different equations for estimated GFR (eGFR) have been developed in children, using simple or more complex regression strategies with gold standard GFR measurements as a dependent variable. As a rule, estimation strategies relying on more than one marker - either by calculating the average of single parameter equations or by using more complex equations incorporating several parameters - outperform eGFR estimations using only a single marker. This in-depth review will discuss the physiology, measurement and clinical use of creatinine, urea, cystatin C, beta-trace protein, and beta-2 microglobulin in children. It will also address the generation of eGFR equations in children and provide an overview of currently available eGFR equations for the pediatric age group.

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Pediatric Reference Intervals for Several Biochemical Analytes in School Children in Central Taiwan

Cited by 21 publications

References 19 publications

Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children

Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children

First National Report on Aminotransaminases` Percentiles in Children of the Middle East and North Africa (MENA): the CASPIAN-III Study

Endogenous markers for kidney function in children: a review

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