Pediatric Radiopharmaceutical Administered Doses: 2010 North American Consensus Guidelines

Gelfand, Michael J.; Parisi, Marguerite T.; Treves, S. Ted

doi:10.2967/jnumed.110.084327

Cited by 193 publications

(157 citation statements)

References 16 publications

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“…A review of the literature and discussions within the NMGI confirmed that there were 4 main guidelines on pediatric administered activity currently in use: the 2010 North American Consensus Guidelines (10,11), the European Association of Nuclear Medicine (EANM) dosage card (12)(13)(14), the Japanese Society of Nuclear Medicine (JSNM) guidelines (15), and the Administration of Radioactive Substances Advisory Committee (ARSAC) "Notes for Guidance on the Clinical Administration of Radiopharmaceuticals and Use of Sealed Radioactive Sources" (revised 2014) (16). The ARSAC notes will not be discussed because the scaling factor from adult administered activity to pediatric administered activity used in the ARSAC document is based on an older version of the EANM guidelines.…”

Section: Current Standards For Pediatric Administered Activitiesmentioning

confidence: 98%

“…Thus, the nuclear medicine community may rely on tools such as surveys that use the collective experience of the community to help develop guidelines and standardize administered activities. However, some such surveys have shown large variations in practice, resulting in a necessary focus on dedicated pediatric facilities for consistent findings (8); even then, disparities have been found (9), and such findings were used to initiate development of the 2010 North American Consensus Guidelines (10,11).…”

Section: Current Standards For Pediatric Administered Activitiesmentioning

confidence: 99%

“…The variability for some of the procedures was considerably greater than this. This level of variability became a topic of discussion among the North American pediatric nuclear medicine community, eventually leading to the development and publication of the North American Consensus Guidelines of administered doses for children and adolescents, which were adopted by the SNMMI, the American College of Radiology, and the Society for Pediatric Radiology and promoted by the Image Gently campaign (10,11).…”

Section: Survey Of North American Pediatric Institutions (2007 and 20mentioning

confidence: 99%

See 2 more Smart Citations

Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 2—Current Standards and the Path Toward Global Standardization

et al. 2016

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The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 and consists of 13 international organizations with direct involvement in nuclear medicine. The underlying objectives of the NMGI are to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. For its first project, the NMGI decided to consider the issues involved in the standardization of administered activities in pediatric nuclear medicine. It was decided to divide the final report of this project into 2 parts. Part 1 was published in this journal in the spring of 2015. This article presents part 2 of the final report. It discusses current standards for administered activities in children and adolescents that have been developed by various professional organizations. It also presents an evaluation of the current practice of pediatric nuclear medicine specifically with regard to administered activities as determined by an international survey of 313 nuclear medicine clinics and centers from 29 countries. Lastly, it provides recommendations for a path toward global standardization of the administration of radiopharmaceuticals in children. Int he summer of 2012, several international organizations directly involved in the practice and science of nuclear medicine decided to engage in a project of common interest for the betterment of the field worldwide. The underlying objectives were to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. This endeavor was named the Nuclear Medicine Global Initiative (NMGI) and includes societies from various countries as well as several multinational organizations in the field of nuclear medicine (Table 1).The group decided that the first NMGI project would be to consider the issues involved in the standardization of administered activities in pediatric nuclear medicine. Part 1 of this report described the reasons for the choice of project (1). It also provided a review of the value of pediatric nuclear medicine, the current understanding of the carcinogenic risk of radiation as it pertains to the administration of radiopharmaceuticals in children, and the application of dosimetric models in children. Gaps in current knowledge on these topics were also discussed. A listing of pertinent educational and reference resources, available in print and online, was provided and described.

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Section: Current Standards For Pediatric Administered Activitiesmentioning

confidence: 98%

Section: Current Standards For Pediatric Administered Activitiesmentioning

confidence: 99%

Section: Survey Of North American Pediatric Institutions (2007 and 20mentioning

confidence: 99%

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Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 2—Current Standards and the Path Toward Global Standardization

et al. 2016

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“…PET/CT brain images were acquired on a PET/CT scanner (Biograph mCT; Siemens Medical Solutions) at 40 min after intravenous injection of 18 F-FDG (3.7 MBq/kg) (19,20). PET and MR images were coregistered using the vender-provided Fusion Registration Software implemented in the syngo MultiModality Workplace (Siemens Medical Solutions).…”

Section: Pet Image Analysismentioning

confidence: 99%

Glucose Metabolic Profile by Visual Assessment Combined with Statistical Parametric Mapping Analysis in Pediatric Patients with Epilepsy

Zhu

Feng

et al. 2017

J Nucl Med

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PET with 18 F-FDG has been used for presurgical localization of epileptogenic foci; however, in nonsurgical patients, the correlation between cerebral glucose metabolism and clinical severity has not been fully understood. The aim of this study was to evaluate the glucose metabolic profile using 18 F-FDG PET/CT imaging in patients with epilepsy. Methods: One hundred pediatric epilepsy patients who underwent 18 F-FDG PET/CT, MRI, and electroencephalography examinations were included. Fifteen age-matched controls were also included. 18 F-FDG PET images were analyzed by visual assessment combined with statistical parametric mapping (SPM) analysis. The absolute asymmetry index (jAIj) was calculated in patients with regional abnormal glucose metabolism. Results: Visual assessment combined with SPM analysis of 18 F-FDG PET images detected more patients with abnormal glucose metabolism than visual assessment only. The jAIj significantly positively correlated with seizure frequency (P , 0.01) but negatively correlated with the time since last seizure (P , 0.01) in patients with abnormal glucose metabolism. The only significant contributing variable to the jAIj was the time since last seizure, in patients both with hypometabolism (P 5 0.001) and with hypermetabolism (P 5 0.005). For patients with either hypometabolism (P , 0.01) or hypermetabolism (P 5 0.209), higher jAIj values were found in those with drug resistance than with seizure remission. In the post-1-y follow-up PET studies, a significant change of jAIj (%) was found in patients with clinical improvement compared with those with persistence or progression (P , 0.01). Conclusion: 18 F-FDG PET imaging with visual assessment combined with SPM analysis could provide cerebral glucose metabolic profiles in nonsurgical epilepsy patients. jAIj might be used for evaluation of clinical severity and progress in these patients. Patients with a prolonged period of seizure freedom may have more subtle (or no) metabolic abnormalities on PET. The clinical value of PET might be enhanced by timing the scan closer to clinical seizures.

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“…Also, the American College of Radiology, the Society of Pediatric Radiology, and the Society of Nuclear Medicine and Molecular Imaging (SNMMI) convened a working group for pediatric nuclear medicine that resulted in the development and the publication of the North American consensus guidelines for administered activity in children and adolescents (6). A public relations campaign was launched ("Go with the Guidelines") that sought to deliver a copy of the guidelines to every nuclear medicine clinic in North America by its publication in multiple journals and insertion into the radiopharmaceutical packages delivered to the clinics.…”

mentioning

confidence: 99%

Effects of Image Gently and the North American Guidelines: Administered Activities in Children at 13 North American Pediatric Hospitals

et al. 2015

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Pediatric Radiopharmaceutical Administered Doses: 2010 North American Consensus Guidelines

Cited by 193 publications

References 16 publications

Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 2—Current Standards and the Path Toward Global Standardization

Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 2—Current Standards and the Path Toward Global Standardization

Glucose Metabolic Profile by Visual Assessment Combined with Statistical Parametric Mapping Analysis in Pediatric Patients with Epilepsy

Effects of Image Gently and the North American Guidelines: Administered Activities in Children at 13 North American Pediatric Hospitals

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