Pediatric Prescriptions of Proton Pump Inhibitors in France (2009-2019): A Time-Series Analysis of Trends and Practice Guidelines Impact

Pharmacoepidemiology: A key complementary tool to evaluate the paediatric exposome

“…The findings of Schaffer and colleagues are consistent with those from previous large studies in countries with advanced economies regarding the high level of POP observed, 5,10,11 but detailed comparisons of POP reported in these studies have shown major discrepancies of drug prescription level by age‐classes 5,10 . Given that the epidemiological patterns of chief paediatric diseases are similar, overall, in countries with advanced economies, the concerning high level of POP observed in some countries for some therapeutic classes is probably mainly related to parents' health literacy, physicians' practices and health care systems characteristics 5 .…”

“…Given that the epidemiological patterns of chief paediatric diseases are similar, overall, in countries with advanced economies, the concerning high level of POP observed in some countries for some therapeutic classes is probably mainly related to parents' health literacy, physicians' practices and health care systems characteristics 5 . Regulatory decisions and clinical guidelines can have some impact on this POP's level 10,11 . However, studies have underlined challenges in the implementation of clinical guidelines given the obstacles that impede changes in the attitudes of parents and prescribers, 10 and prevent movement towards the rational prescriptions as recommended by WHO 7…”

“…Regulatory decisions and clinical guidelines can have some impact on this POP's level 10,11 . However, studies have underlined challenges in the implementation of clinical guidelines given the obstacles that impede changes in the attitudes of parents and prescribers, 10 and prevent movement towards the rational prescriptions as recommended by WHO 7…”

Proton pump inhibitors for infants in three Scandinavian countries increased from 2007 to 2020 despite international recommendations

“…Nationwide data for non‐hospitalised infants are scarce, but a study from New Zealand found that 5.2% of infants received PPIs in 2012, more than twofold the use in 2005 20 . Similarly, increase in the use of PPIs was found in Ireland, Belgium and France 21–23 . Of note, the present study covers the period before and after the international guidelines were published, and is the first to prove that a reduction in infant PPI dispensing is possible.…”

Efficacy and safety of medical and nutritional management of gastroesophageal reflux in formula-fed infants: a narrative review

“…The syrup did also contain alcohol, comparable with a daily intake of a coffee spoon of wine in an infant. Proton pump inhibitors (PPIs) are among the most commonly prescribed drugs in infants and children with still a dramatic rise [4 ▪ ,34,35 ▪ ]. The main reason is the perception that crying and irritability in infants that do not present with frequent overt regurgitation and vomiting is due to acid GER.…”