Pediatric phantom library constructed from ICRP mesh-type reference computational phantoms (MRCPs)

Kim, Suhyeon; Shin, Bangho; Choi, Chansoo; Kim, Hyeonil; Ha, Sangseok; Chung, Beom Sun; Han, Haegin; Moon, Sungho; Son, Gahee; Kim, Jaehyo; Choi, Ji Won; Kim, Chan Hyeong; Yeom, Yeon Soo

doi:10.1016/j.net.2024.03.022

Cited by 1 publication

(1 citation statement)

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“…Generally, a phantom that is closer to the patient's age and weight can be used if available. A library of pediatric mesh phantoms is being developed (Kim et al 2024) and the adult mesh phantoms have been deformed to represent different weights (Lee et al 2019), but at the time of writing these phantoms are only available upon request. A new TOPAS extension named 'OpenTOPAS-MeshGeom' was developed to enable the handling of tetrahedral geometries for this work.…”

Section: Anatomical Phantom Extensionmentioning

confidence: 99%

A framework for in-field and out-of-field patient specific secondary cancer risk estimates from treatment plans using the TOPAS Monte Carlo system

Meyer,

Peters,

Tamborino

et al. 2024

Phys. Med. Biol.

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Objective: To allow the estimation of secondary cancer risks from radiation therapy treatment plans in a comprehensive and user-friendly Monte Carlo framework. Approach: Patient planning CTs were extended superior-inferior using the ICRP Publication 145 computational mesh phantoms and skeletal matching. Dose distributions were calculated with the TOPAS Monte Carlo system using novel mesh capabilities and the DICOM-RT interface. Finally, in-field and out-of-field cancer risk was calculated using both sarcoma and carcinoma risk models with two alternative parameter sets.Main results: The TOPAS Monte Carlo framework was extended to facilitate epidemiological studies on radiation-induced cancer risk. The framework is efficient and allows automated analysis of large datasets. Out-of-field organ dose was small compared to in-field dose, but the risk estimates indicate a non-negligible contribution to the total radiation induced cancer risk. Significance: The implementation of anatomical extension, mesh phantom capabilities, and cancer risk models into the TOPAS Monte Carlo system makes state-of-the-art out-of-field dose calculation and risk estimation accessible to a large pool of users while facilitating further refinement of risk models and sensitivity analysis of patient specific treatment options.

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Section: Anatomical Phantom Extensionmentioning

confidence: 99%