Pediatric Origins of Nephrolithiasis-Associated Atherosclerosis

Kusumi, Kirsten; Smith, Sally A.; Barr-Beare, Evan; Saxena, Vijay; Schober, Megan S.; Moore‐Clingenpeel, Melissa; Schwaderer, Andrew L.

doi:10.1016/j.jpeds.2015.08.014

Cited by 11 publications

(6 citation statements)

References 43 publications

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“…Increased rates of low BMD and increased carotid artery wall thickness have also been identified in preliminary studies of children and adults with USD (9)(10)(11)(12). USD is also associated with CKD, diabetes mellitus, and hypertension (13,14).…”

Section: Epidemiologymentioning

confidence: 84%

Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health

Scales

Tasian

Schwaderer

et al. 2016

CJASN

Self Cite

130

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Expanding epidemiologic and physiologic data suggest that urinary stone disease is best conceptualized as a chronic metabolic condition punctuated by symptomatic, preventable stone events. These acute events herald substantial future chronic morbidity, including decreased bone mineral density, cardiovascular disease, and CKD. Urinary stone disease imposes a large and growing public health burden. In the United States, 1 in 11 individuals will experience a urinary stone in their lifetime. Given this high incidence and prevalence, urinary stone disease is one of the most expensive urologic conditions, with health care charges exceeding $10 billion annually. Patient care focuses on management of symptomatic stones rather than prevention; after three decades of innovation, procedural interventions are almost exclusively minimally invasive or noninvasive, and mortality is rare. Despite these advances, the prevalence of stone disease has nearly doubled over the past 15 years, likely secondary to dietary and health trends. The NIDDK recently convened a symposium to assess knowledge and treatment gaps to inform future urinary stone disease research. Reducing the public health burden of urinary stone disease will require key advances in understanding environmental, genetic, and other individual disease determinants; improving secondary prevention; and optimal population health strategies in an increasingly cost-conscious care environment.

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Section: Epidemiologymentioning

confidence: 84%

Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health

Scales

Tasian

Schwaderer

et al. 2016

CJASN

Self Cite

130

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“…1 It can cause post-renal acute kidney injury via obstruction of urinary outflow, often associated with rapid deterioration in renal function. 2 Kidney stone is one of main disorders of the urinary tract. 3 Kidney stone may have various compositions which include, in order of decreasing frequency: calcium oxalate, uric acid, calcium phosphate, struvite, and cystine.…”

Section: Introductionmentioning

confidence: 99%

Association of MMP‐9 gene polymorphisms with nephrolithiasis patients

Mehde

Mehdi

Yusof

et al. 2017

Clinical Laboratory Analysis

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Background Nephrolithiasis is one of the causes which lead to chronic kidney disease (CKD). Matrix metalloproteinases (MMPs) are endopeptidases degrading extracellular matrix which correlate with the pathogenesis of atherosclerosis. The current study was designed to analyze the association of (R279Q, C1562T) polymorphism of MMP‐9 with nephrolithiasis patients. Methods Genotyping of MMP‐9/R279Q and of MMP‐9/C1562T polymorphism were carried out by PCR‐based restriction digestion method. Serum level of MMP‐9, oxidative stress marker, MDA, and uric acid were measured in patients and control. Results Allele frequencies of the MMP‐9/C1562T polymorphism for C and T allele were 71.25% and 28.75% in patients, 87.08% and 12.92% in control respectively. The homozygote TT was more frequent in the nephrolithiasis patients group, while T allele frequency was significantly higher in the nephrolithiasis patients group than in the control group. The patients with CT and TT genotype showed a significant increase in serum MMP‐9, Total Oxidant Status (TOS), Oxidative Stress Index (OSI), Malondialdehyde (MDA), and uric acid when compared to CC genotype in patients with nephrolithiasis. The R279Q polymorphism site with regard to the relationship with nephrolithiasis was not significant. Conclusion The result indicates that patients with TT genotype had an increased risk of stones. Also, the results demonstrate that TT allele of the C1562T polymorphism in the MMP‐9gene is related with an increase of oxidative stress in nephrolithiasis patients and may possibly impose a risk for cardiovascular diseases in patients with TT genotype of MMP‐9.

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“…To date, there is a single study that investigated atherosclerosis and cardiovascular complications in children. Carotid intima media thickness (cIMT) which is a sign of subclinical atherosclerosis was found to be increased in children with nephrolithiasis this study [13].…”

Section: Introductionmentioning

confidence: 53%

Assessment of Cardiac Functions and Subclinical Cardiovascular Risk In Children with Urolithiasis: An Initial Study

Elmacı

Alp

Dönmez

2021

Preprint

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Information on cardiovascular problems related to childhood urinary stone disease is limited. The aim of this study is to assess the ventricular functions and subclinical cardiovascular risk in children with urolithiasis using echocardiographic measurements. Children readily diagnosed with urolithiasis were enrolled in the study as well as children with no urinary stone disease confirmed via urinary ultrasonography. Body mass index (BMI) and blood pressures were noted as well as basic serum parameters. Carotid intima media thickness (cIMT), epicardial fat tissue (EFT) thickness and periaortic fat tissue (PFT) thickness were measured via transthoracic echocardiography in addition to pulsed and tissue Doppler imaging. Myocardial performance indexes were also calculated and correlation analyses were made. A total of 17 patients (10 boys) were enrolled in the study with a mean age of 8.57 ± 2.62 years. There were 17 children (12 boys) in the control group and their mean age was 9.53 ± 1.72 years. There was no statistically significant difference between the two groups in terms of demographic and laboratory variables. Tissue Doppler echocardiography revealed that Tei indexes of left ventricle, right ventricle and septum were significantly higher in the study group than in the controls (p < 0.001 for all). The cIMT (0.041 ± 0.012 vs. 0.025 ± 0.002), EFT (0.432 ± 0.083 vs. 0.325 ± 0.032) and PFT thicknesses (0.138 ± 0.029 vs. 0.113 ± 0.008) of the study group were statistically higher than the control group (p < 0.001, p < 0.001 and p = 0.002, respectively) indicating a higher CVD risk.Conclusions: Children with urolithiasis presented not only biventricular early systolic and diastolic dysfunction but also subclinical atherosclerosis in early ages. Cardiovascular complications should be considered in the follow-up and treatment of these patients.

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Pediatric Origins of Nephrolithiasis-Associated Atherosclerosis

Cited by 11 publications

References 43 publications

Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health

Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health

Association of MMP‐9 gene polymorphisms with nephrolithiasis patients

Assessment of Cardiac Functions and Subclinical Cardiovascular Risk In Children with Urolithiasis: An Initial Study

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