Pediatric Oral Pathology

Delaney, Jayne E.; Keels, Martha Ann

doi:10.1016/s0031-3955(05)70260-1

Cited by 18 publications

(2 citation statements)

References 7 publications

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“…4,5 They can appear as a smooth single or multiple lobulated compressible mass of variable size. 1,6,7 However, hemangiomas can mimic other tumor or cystic lesions as in this case report. In our patient, the surface mucosa was of normal color without the dark purple-blue color that is characteristic of hemangiomas.…”

Section: Discussionmentioning

confidence: 72%

Hemangioma of the Buccal Mucosa of the Cheek Presenting as a Dermoid Cyst: A Case Report

DMD MD PHD MPH MSEd

2023

JCDP

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This case report presents a 73-year old Asian female with a presumed dermoid cyst in the buccal mucosa of the left cheek that was visible and embarrassing to her. Histopathology revealed the mass to be consistent with a cavernous hemangioma. Hemangiomas are benign vascular tumors of mesenchymal origin. It is usually present at birth but can develop later in life. It commonly occurs in the head and neck region, but rarely in the oral cavity.

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Section: Discussionmentioning

confidence: 72%

Hemangioma of the Buccal Mucosa of the Cheek Presenting as a Dermoid Cyst: A Case Report

DMD MD PHD MPH MSEd

2023

JCDP

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“…While the presence of pathogenic bacteria and inflammation are prerequisites for periodontal bone loss, the precise mechanisms underlying host susceptibility to periodontitis, maintenance of chronic inflammation, and triggering of alveolar bone resorption are still not clearly understood. For instance, it is unclear why some individuals have periodontal pathogens in their periodontium without manifesting the disease, and why untreated gingivitis does not always result in periodontitis …”

Section: Introductionmentioning

confidence: 99%

Enhanced dual function of osteoclast precursors following calvarial Porphyromonas gingivalis infection

Cai

Zhao

et al. 2020

J of Periodontal Research

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Background and objective:Excessive osteoclast activity is a major characteristic of pathogenic bone loss in inflammatory bone diseases including periodontitis.However, beyond the knowledge that osteoclasts are differentiated from the monocyte/macrophage lineage and share common ancestry with macrophages and DC, the nature and function of osteoclast precursors are not completely understood. Furthermore, little is known about how osteoclast precursors respond to bacterial infection in vivo. We have previously demonstrated in vitro that the periodontal pathogen Porphyromonas gingivalis (Pg) plays a biphasic role on the receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast differentiation. In this study, we investigated the in vivo effect of Pg infection on the regulation of osteoclast precursors, using a mouse calvarial infection model. Methods and results: C57BL/6 wild-type and the myeloid differentiation factor 88 knockout (MyD88 −/− ) mice were infected with Pg by calvarial injection. Local and systemic bone loss, and the number and function of CD11b + c-fms + cells from bone marrow and spleen were analyzed. Our results show that Pg infection induces localized inflammatory infiltration and osteoclastogenesis, as well as increased number and osteoclastogenic potential of CD11b + c-fms + osteoclast precursors in the bone marrow and periphery. We also show that CD11b + c-fms + RANK + and CD11b + c-fms + RANK − are precursors with similar osteoclastogenic and pro-inflammatory potentials. In addition, CD11b + c-fms + cells exhibit an antigen-specific T-cell immune-suppressive activity, which are increased with Pg infection. Moreover, we demonstrate that MyD88 is involved in the regulation of osteoclast precursors upon Pg infection. Conclusions:In this study, we demonstrate an enhanced dual function of osteoclast precursors following calvarial Pg infection. Based on our findings, we propose the following model: Pg infection increases a pool of precursor cells that can be shunted toward osteoclast formation at the infection/inflammation sites, while at the same

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