Pediatric obesity: Current concepts

Greydanus, Donald E.; Agana, Marisha; Kamboj, Manmohan K.; Shebrain, Saad; Soares, Neelkamal; Eke, Ransome; Patel, Dilip R.

doi:10.1016/j.disamonth.2017.12.001

Cited by 58 publications

(65 citation statements)

References 427 publications

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“…According to the World Health Organization (WHO) report, there are more than 340 million overweight and obese children and adolescent (5–19 years) around the world (Greydanus et al, ). Consequently, this obesity burden will affect the current and future health of children and may reduce their life expectancy (Tyson & Frank, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial

Saraf‐Bank

Ahmadi

Paknahad

et al. 2019

Phytotherapy Research

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Introduction: It is well known that there is a strong linkage between obesity, systemic low-grade inflammation, and oxidative stress in the pediatric population. Possible strategies that might control obesity and its relevant problems in this crucial group are of utmost importance. Therefore, the aim of this study was to evaluate the effects of curcumin supplements on inflammation, oxidative stress, and chemerin levels in adolescent girls.Methods: Totally, 60 overweight and obese adolescent girls were randomly assigned to either placebo or intervention group in a randomized placebocontrolled parallel trial design. Adolescents consumed one 500-mg curcumin or placebo per day along with a slight weight loss diet for 10 weeks. High-sensitive Creactive protein (hs-CRP), interleukin 6 (IL-6), total antioxidant capacity (TAC), malondialdehyde (MDA), chemerin levels, and anthropometric measurements were assessed at the beginning and end of the trial.Results: Curcumin supplementation had a significant effect on IL-6 levels and oxidative stress markers including TAC and MDA in crude model. After controlling the effects of confounders, curcumin supplementation had a substantial effect on inflammation (hs-CRP and IL-6) and oxidative stress (TAC) marker of adolescents.Discussion: Ten weeks of curcumin supplementation had beneficial effects on inflammation and oxidative stress markers among postpubescent overweight and obese girl adolescents.

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Section: Introductionmentioning

confidence: 99%

Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial

Saraf‐Bank

Ahmadi

Paknahad

et al. 2019

Phytotherapy Research

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“…Ameer and Weintraub 10 very nicely review the epidemiology, pathogenesis, and clinical relevance of obesity as well as the many answers and remaining questions regarding effective obesity treatments and drug dosing across the ageweight obesity spectrum. 11 Though many reviews have been published on dosing strategies of select drugs in obese to morbidly obese pediatric patients, 12 important questions remain as to the ideal weight parameter (eg, total, ideal, fat-free body weight) to use in defining an optimal dose. Some have attempted to utilize a drug group's known physicochemical characteristics to improve dose projections in obese patients with limited success, underscoring that no one approach is ideal for all drugs.…”

Section: S8mentioning

confidence: 99%

“…One major contemporary challenge to this entire process is the increasing scourge of obesity worldwide and woven throughout the pediatric age continuum. Ameer and Weintraub very nicely review the epidemiology, pathogenesis, and clinical relevance of obesity as well as the many answers and remaining questions regarding effective obesity treatments and drug dosing across the age‐weight obesity spectrum . Though many reviews have been published on dosing strategies of select drugs in obese to morbidly obese pediatric patients, important questions remain as to the ideal weight parameter (eg, total, ideal, fat‐free body weight) to use in defining an optimal dose.…”

mentioning

confidence: 99%

Developmental Pharmacotherapy: The Interface Between Ontogeny and Drug Effect

Reed

Anker

2018

The Journal of Clinical Pharma

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“…The long-term effects are worrying due to the increased morbidity and mortality rates, which are independent of the weight when the obese children become adults. [3][4][5][6] Mexican schools have included physical activities and have introduced healthy food to improve the situation. Some hospitals have intervention programs for prevention and treatment of childhood obesity, but all these strategies remain insufficient.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Homeopathy in Addition to a Multidisciplinary Intervention for Overweight or Obesity in Mexican Adolescents: Study Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2020

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Background Current recommendations for treating obesity in adolescence include a comprehensive approach (nutritional, behavioral, and exercise). Calcarea carbonica ostrearum (CCO) is a homeopathic medicine usually prescribed in obese individuals, but its effects on weight and body fat are not completely known. Objective The aim of this study will be to evaluate the efficacy of homeopathic CCO, in addition to a multidisciplinary intervention (diet, motivational support, and exercise program), on body fat and weight in obese adolescents. Methods/Design A randomized, placebo-controlled, double-blind, parallel-group, superiority trial with 3-month study duration will be undertaken. The study will be conducted in a public research hospital in Mexico City, Hospital Juárez de México, in the outpatient services of homeopathy and sports medicine. Eighty non-diabetic adolescents, 12 to 19 years old, who are overweight or obese, will be included. The primary outcome: change in body fat percentage at week 12. The secondary outcomes: change in mean total weight, total body mass index, fat mass index, waist–hip ratio, lean muscle mass, fasting glucose, insulin, insulin resistance, lipid profile, score of Center for Epidemiologic Studies Depression Scale Revised (CESD-R) and score of Screen for Child Anxiety-Related Emotional Disorders (SCARED) at week 12. Efficacy data will be analyzed in the intention-to-treat sample. To determine the difference in the outcomes between groups at baseline and week 12, data will be analyzed using Student's t-test. Discussion This is the first randomized controlled trial aimed to determine the fat-reducing efficacy in obese adolescents of a homeopathic medicine, CCO, given in addition to a multidisciplinary intervention, compared with placebo plus the same intervention. It is an attempt to support scientific evidence in homeopathy for one of the most common chronic diseases, which causes high mortality due to its complications. ClinicalTrials.gov Identifier: NCT03945396 https://clinicaltrials.gov/ct2/show/NCT03945396?term=homeopathy+for+obesity+in+Mexican+adolescents&rank=1

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Pediatric obesity: Current concepts

Cited by 58 publications

References 427 publications

Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial

Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial

Developmental Pharmacotherapy: The Interface Between Ontogeny and Drug Effect

Efficacy of Homeopathy in Addition to a Multidisciplinary Intervention for Overweight or Obesity in Mexican Adolescents: Study Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial

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