Pediatric Nonalcoholic Fatty Liver Disease: A Report from the Expert Committee on Nonalcoholic Fatty Liver Disease (ECON)

Kohli, Rohit; Sunduram, Shikha; Mouzaki, Marialena; Ali, Sabina; Sathya, P; Abrams, Stephanie H.; Xanthakos, Stavra A.; Vos, Miriam B.; Schwimmer, Jeffrey B.

doi:10.1016/j.jpeds.2015.12.016

Cited by 21 publications

(28 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Over the last few decades, the prevalence of metabolic disorders such as non-alcoholic fatty liver disease (NAFLD) has been increasing. 20,21 This may be attributed to chronic consumption of high caloric diets and sedentary lifestyles. 22 Various diet-induced animal models have been developed to study the pathogenesis of diabetes and the associated metabolic disorders.…”

Section: Discussionmentioning

confidence: 99%

<p>Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic fatty liver disease in a diet-induced pre-diabetes rat model</p>

Gamede¹,

Mabuza²,

Ngubane³

et al. 2019

DMSO

View full text Add to dashboard Cite

Background: The increased prevalence of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients is becoming a worldwide health burden. Studies have indicated, however, that the onset of NAFLD occurs during pre-diabetes, a condition that often precedes the onset of T2DM. Oleanolic acid has been reported to improve glucose homeostasis in diet-induced pre-diabetes; however, the effects of this triterpene on liver function have not been evaluated. Purpose: This study was aimed at evaluating the therapeutic effects of oleanolic acid (OA) on selected markers of NAFLD in a pre-diabetes rat model. Methods and materials: Pre-diabetes was induced by exposing Sprague Dawley rats to a high-fat high-carbohydrate diet for 20 weeks. The pre-diabetic rats were then treated with OA (80 mg/kg) or metformin (500 mg/kg) in the presence and absence of dietary interventions for a period of 12 weeks. The effects of OA were evaluated on parameters including plasma triglycerides (TGs), very low-density lipoprotein (VLDL) particles, bilirubin, AST, ALT, SREBP and antioxidant profile while the livers were collected for histological analysis. Results: The findings of this study showed that the administration of OA to pre-diabetic rats ameliorated body/liver weights ratio and significantly decreased plasma triglycerides (TGs) and VLDL. Furthermore, OA also ameliorated hepatic oxidative stress, lowered the SREBP expression and intrahepatic TGs. In addition, OA administration decreased plasma concentrations of bilirubin and liver damage enzyme biomarkers. Conclusion: The findings of the study suggest that OA ameliorates the risk of developing pre-diabetes-related NAFLD through the prevention of intrahepatic fat accumulation while also lowering hepatic inflammation.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic fatty liver disease in a diet-induced pre-diabetes rat model</p>

Gamede¹,

Mabuza²,

Ngubane³

et al. 2019

DMSO

View full text Add to dashboard Cite

show abstract

“…NAFLD is an inclusive term referring to the full spectrum of diseases from fatty infiltration of the liver, typically more than 5% of the liver analyzed using imaging, direct quantification, or histological estimation [1]. Because obesity is strongly correlated with NAFLD, and the obese pediatric population has increased, the prevalence of NAFLD has increased and has become the most common cause of chronic pediatric liver disease in developed countries [2]. In Korea, the estimated prevalence of adolescents with NAFLD also increased from 4.7% in 2010 to 5.9% in 2015, and an increased ALT level was associated with the male sex, obesity and truncal obesity [3].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the dietary factors associated with suspected pediatric nonalcoholic fatty liver disease and potential liver fibrosis: Korean National Health and Nutrition Examination Survey 2014-2017

Kim

Lee

2020

BMC Pediatr

View full text Add to dashboard Cite

Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased as the obese pediatric population has increased. NAFLD causes progressive liver injury and the only effective treatment is lifestyle modifications. However, few studies have examined the dietary risk factors for pediatric NAFLD or liver fibrosis. Here, we evaluated the dietary factors associated with suspected NAFLD and potential liver fibrosis in Korean children. Methods: Data collected from 1674 children and adolescents aged 10-18 years during the 2014-2017 Korean National Health and Nutrition Examination Surveys analyzed. The 24-h recall method measured the food consumed 1 day before the survey. The "suspected NAFLD" group included excessive body mass index (BMI) subjects ≥ 85th percentile) with alanine aminotransferase (ALT) levels exceeding the upper normal limit (24.1 U/L for boys and 17.7 U/L for girls); the "healthy control" group included subjects with a BMI and ALT level below these thresholds. Sodium intake was assessed by the urinary sodium-to-urinary specific gravity unit ratio (U-Na-to-SGU ratio). A pediatric NAFLD index (PNFI) higher than 3 indicated potential liver fibrosis. Results: The overall prevalence of suspected NAFLD and potential liver fibrosis was 8.2 and 4.5%, respectively. The suspected NAFLD group had a larger proportion of males and subject with a greater height, BMI standard deviation score (BMI-SDS), systolic and diastolic blood pressure SDS, waist circumference, hemoglobin A1c, and levels of total cholesterol, triglycerides, aspartate aminotransferase (AST) and ALT than the control group. The suspected NAFLD group presented significantly higher U-Na-to-SGU ratios and cholesterol intake. The PNFI > 3 subgroup included a significantly larger proportion of males and subjects with higher BMI-SDS, AST and ALT values, and intake of water, carbohydrate, protein, calcium, phosphorus, iron and vitamin B2. After adjusting for confounders, male, BMI-SDS, AST, and protein and carbohydrate intake were independent risk factors for potential liver fibrosis. Niacin intake was an independent protective factor for potential liver fibrosis.

show abstract

“…Su prevalencia varía según la edad y el método de detección empleado, que puede incluir, la determinación de ALT, estudios de imágenes o biopsia hepática. La determinación sérica de ALT constituye el mejor marcador bioquímico para detectar EHNA en niños y adolescentes, ampliamente aceptada como una prueba accesible, aunque su utilidad es controversial especialmente relacionado al punto de corte correcto [11] .…”

Section: Introductionunclassified

Alanina aminotransferasa como marcador en el diagnóstico de síndrome metabólico y riesgo cardiovascular en niños con obesidad

et al. 2019

View full text Add to dashboard Cite

Objetivo: Evaluar la alanina aminotransferasa (ALT) como marcador en el diagnóstico de síndrome metabólico (SM) y riesgo cardiovascular (RCV) en niños con obesidad exógena.Materiales y métodos: Estudio transversal. Se incluyeron niños con obesidad exógena de 2 a 14 años, atendidos en la Unidad de Endocrinología Pediátrica del Hospital NacionalCayetano Heredia, entre el 2014 al 2018. Se definió enfermedad hepática no alcohólica (EHNA) considerando dos puntos de corte de ALT; en mujeres: >22,1U/L y >44U/L, en varones: >25,8U/L y >50U/L. Se definió SM según la Academia Americana de Pediatría y RCV con TG/HDL-C ≥3,5. Aplicamos Chi cuadrado, considerándose significativo p<0,05. Estimamos sensibilidad(S), especificidad (E) y likelihood ratios (LR). Resultados: Se incluyeron 347 niños obesos (54,7% varones). La frecuencia de EHNA fue de 23,1%. La sensibilidad y especificidad para el diagnóstico de SM con ALT >22,1U/L y >25,8U/L fue 79,4% y 37,6% respectivamente y, con ALT>44U/L y >50U/L fue 28,6% y 83,3%. La ALT con punto de corte mayor en conjunto con TG/HDL-C≥3,5 mostró una especificidad del 96,9% y un likelihood ratio + (LR+) de 6,7. Conclusión: La ALT con un punto de corte >44U/L en mujeres y >50U/L en varones, es un marcador bioquímico útil en la identificación de SM y riesgo cardiovascular en niños con obesidad exógena desde los primeros años de vida.

show abstract

Pediatric Nonalcoholic Fatty Liver Disease: A Report from the Expert Committee on Nonalcoholic Fatty Liver Disease (ECON)

Cited by 21 publications

References 58 publications

<p>Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic fatty liver disease in a diet-induced pre-diabetes rat model</p>

<p>Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic fatty liver disease in a diet-induced pre-diabetes rat model</p>

Analysis of the dietary factors associated with suspected pediatric nonalcoholic fatty liver disease and potential liver fibrosis: Korean National Health and Nutrition Examination Survey 2014-2017

Alanina aminotransferasa como marcador en el diagnóstico de síndrome metabólico y riesgo cardiovascular en niños con obesidad

Contact Info

Product

Resources

About