Pediatric Neurologic Complications Associated With Influenza A H1N1

Landau, Yuval; Grisaru‐Soen, Galia; Reif, Shimon; Fattal‐Valevski, Aviva

doi:10.1016/j.pediatrneurol.2010.08.011

Cited by 51 publications

(39 citation statements)

References 16 publications

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“…Seizure has been reported as the most common neurologic complication of seasonal influenza A and B (6,17), as well as pandemic (H1N1) 2009 (8,18), but shows good prognosis. In contrast, encephalopathy is rare, but it can cause a serious outcome, especially in patients of young age or with underlying neuromuscular disorder (6).…”

Section: Discussionmentioning

confidence: 99%

“…Seasonal influenza A and B viruses have varying degrees of neurovirulence (5) and can cause a variety of neurologic complications including Reye syndrome, Guillian-Barre syndrome, transverse myelitis, encephalopathy, aseptic meningitis, acute disseminated encephalomyelitis (ADEM), acute necrotizing encephalopathy (ANE) and seizures (6,7). Seizures are the most frequently reported neurologic complication and, in young patients, most of these manifest as febrile convulsion (8). Several investigators reported frequent and severe encephalopathy related to seasonal influenza in the past decade (9,10).…”

Section: Introductionmentioning

confidence: 99%

“…Several investigators reported frequent and severe encephalopathy related to seasonal influenza in the past decade (9,10). Several studies have suggested that the pandemic (H1N1) 2009 also causes influenza encephalopathy in children (1,8) and is associated with a notable predominance of disease burden and mortality in children (11).…”

Section: Introductionmentioning

confidence: 99%

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Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children

et al. 2012

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Neurologic complications of children with influenza A H1N1 2009 pandemic, diagnosed in two consecutive influenza seasons were retrospectively reviewed to seek better outcomes in future outbreaks. Patient demographics, clinical manifestations and neurologic outcomes were reviewed. A total of 1,389 children were diagnosed with influenza A H1N1 by real-time reverse transcriptase-polymerase chain reaction. Of these, 23 (1.7%) patients had neurologic involvement. Their mean age was 5.9 ± 3.6 yr (range, 6 months to 11 yr) and 16 (69.9%) were boys. None of the 23 patients had been vaccinated for influenza A H1N1 and seasonal influenzas. Twenty-two of the 23 patients presented with seizures. Clinical features included febrile convulsion (n = 19), afebrile convulsion (n = 1), aseptic meningitis (n = 1), encephalopathy (n = 1), and acute necrotizing encephalopathy (n = 1). They all were treated with Oseltamivir twice daily for 5 days immediately after nasal and throat swab testing. Twenty-one of the subjects recovered fully, but the youngest two infants experienced severe neurological sequelae. The results indicate that neurologic complications associated with influenza A H1N1 2009 pandemic were mostly mild, but rarely were serious. Prompt intervention leads to a better outcome and vaccination may prevent the disease, thus staving off serious neurological complications following influenza, especially in young infants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children

et al. 2012

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“…67 Initial reports emerged from Japan and the United States [68][69][70][71][72][73][74][75] and recently, a number of case reports as well as surveillance reports by CDC have been issued on neurologic complications of Influenza A (in particular pandemic H1N1) disease. [76][77][78][79][80][81][82][83][84][85][86][87][88] Example 3: Encephalitis as an adverse event following immunization (AEFI)…”

Section: Example 1: the Discussion Around Rotavirus Encephalitis/ Encmentioning

confidence: 99%

The Value of Standardized Case Definitions in Encephalitis Clinical Research

Rath¹

2011

Pathogenesis of Encephalitis

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“…Pediatric complications associated with Influenza and results of West Nile encephalitis were reported in studies conducted in Israel (Landau et al 2011). Also, reflecting the 2009 pandemic of influenza, cases of meningitis and meningo-encephalitis in children were reported with influenza A (H1N1) infections from Turkey (Ozdemir et al, 2011, Yildizdas et al, 2011.…”

Section: Studies Conducted On Childhood Encephalitis In Middle-eastermentioning

confidence: 98%

The Neuropsychiatric Consequences of Childhood Encephalitis: A Review of Cases from Middle-Eastern Countries

Tufan¹,

Güven²,

Aslantas-Ertekin³

et al. 2011

Pathogenesis of Encephalitis

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Pediatric Neurologic Complications Associated With Influenza A H1N1

Cited by 51 publications

References 16 publications

Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children

Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children

The Value of Standardized Case Definitions in Encephalitis Clinical Research

The Neuropsychiatric Consequences of Childhood Encephalitis: A Review of Cases from Middle-Eastern Countries

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