Pediatric Myocarditis Protocol: An Algorithm for Early Identification and Management with Retrospective Analysis for Validation

Howard, Ashley; Hasan, Ali M.; Brownlee, John; Mehmood, Noormah; Ali, Mir Amaan; Mehta, Suresh L.; Fergie, Jamie

doi:10.1007/s00246-019-02258-1

Cited by 19 publications

(30 citation statements)

References 39 publications

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“…In our institution, children with myocarditis admitted to the ICU undergo cardiac MRI as a clinical routine protocol to document the diagnosis and to assess the severity of myocarditis (10).…”

Section: Cardiac Mri Resultsmentioning

confidence: 99%

Cardiac MRI in Children with Multisystem Inflammatory Syndrome Associated with COVID-19

et al. 2020

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This case series examines cardiac MRI findings in four children and adolescents admitted to intensive care in April 2020 for multisystem inflammatory syndrome and Kawasaki disease-like features related to COVID-19. Acute myocarditis occurred less than 1 week after onset of fever and gastrointestinal symptoms. Physical examination showed rash and cheilitis/conjunctivitis. All patients recovered after intravenous immunoglobulin therapy. SARS-CoV-2 RT-PCR was negative on nasopharyngeal, stool, and respiratory samples and was positive on serology. Cardiac MRI showed diffuse myocardial edema on T2-STIR sequences and native-T1 mapping, with no evidence of late gadolinium enhancement suggestive of replacement fibrosis or focal necrosis. These findings favor post-infectious myocarditis in children and adolescents with COVID-19.

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Section: Cardiac Mri Resultsmentioning

confidence: 99%

Cardiac MRI in Children with Multisystem Inflammatory Syndrome Associated with COVID-19

et al. 2020

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“…In total, the summary covers 1,891 children diagnosed with myocarditis (Table 1) [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. It is, therefore, a rare disease.…”

Section: Resultsmentioning

confidence: 99%

“…Usually, two peak incidences are observed. The first takes place in the neonatal period and early infancy, and the second -during puberty [6][7][8][9][10][11][12][13]. According to Rodriguez et al [12], the age < 2 is a factor of poor prognosis.…”

Section: Resultsmentioning

confidence: 99%

“…Prodromal symptoms of acute myocarditis occur a couple or a dozen or so days earlier. As works by Howard et al [12] and Rodriguez-Gonzalez et al [13] indicate, history of respiratory infection or gastritis plays a very important role in the diagnosis of the disease. Symptoms of respiratory infection -cough, difficulty breathing, dyspnea -is observed in 57-84% of children, in 20-60%, especially younger ones, vomiting or other dyspeptic symptoms.…”

Section: Resultsmentioning

confidence: 99%

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Zapalenie mięśnia sercowego u dzieci i młodzieży — przegląd piśmiennictwa

2020

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“…Viral aetiology is the most common cause. 1 The first phase is a viral infection, with general symptoms such as respiratory or gastrointestinal symptoms that aid in the diagnosis. A second autoimmune and inflammatory phase occurs due to the activation of the immune system, damaging the cardiac tissue.…”

Section: What Is K Nown and Objec Tivementioning

confidence: 99%

Paediatric viral myocarditis successfully treated with interferon beta‐1b and corticoids

et al. 2021

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What is known and objective: In paediatrics, evidence regarding the treatment of viral myocarditis using interferon beta-1B is restricted to four children older than two years and there are no reported cases of infants. The objective was to describe the efficacy and safety of interferon beta-1B in two infants under one year of age with viral myocarditis. Case summary: Two infants were admitted to the hospital presenting with respiratory symptoms. Echocardiogram showed myocardial damage. Parvovirus-B19 was detected using a PCR assay, and treatment with interferon beta-1B was initiated. Six months later, the cardiac function had recovered in both cases.What is new and conclusion: This is the first published series of cases of infants less than 1 year of age with viral myocarditis treated with interferon beta-1B. | 863CANALES SIGUERO Et AL. revealed moderate-severe left ventricular dysfunction (left ventricular ejection fraction (LVEF) Simpson BP: 39%), left ventricular dilatacion, and severe mitral insufficiency. Additionally, markers of myocardial damage were altered: troponin T 228 ng/L (≤14 ng/L) and NT-proBNP >70.000 pg/mL (≤125 pg/mL). As acute myocarditis was suspected, supportive treatment was initiated, and blood samples were drawn for aetiological study.Empirical antibiotic treatment with cefotaxime 200 mg/kg/ day and intravenous immunoglobulins was initiated. Furthermore, adrenaline (0.05 µg/kg/min), levosimendan, furosemide and spironolactone were administered as supportive treatments.

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Pediatric Myocarditis Protocol: An Algorithm for Early Identification and Management with Retrospective Analysis for Validation

Cited by 19 publications

References 39 publications

Cardiac MRI in Children with Multisystem Inflammatory Syndrome Associated with COVID-19

Cardiac MRI in Children with Multisystem Inflammatory Syndrome Associated with COVID-19

Zapalenie mięśnia sercowego u dzieci i młodzieży — przegląd piśmiennictwa

Paediatric viral myocarditis successfully treated with interferon beta‐1b and corticoids

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