Pediatric Musculoskeletal Nuclear Medicine

Ma, Jason; Kang, Bobby; Treves, S. Ted

doi:10.1055/s-2008-1060335

Cited by 11 publications

(15 citation statements)

References 44 publications

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“…In addition, malignant disease such as leukemia and sarcoma may mimic acute osteomyelitis. 1,5 Blood flow, blood pool, and delayed images show focally high uptake in the affected bone ( Fig. 4).…”

Section: Benign Etiologymentioning

confidence: 96%

“…It offers better sensitivity by improving the spatial resolution because the PET scanner has a greater ability than the gamma camera to image highenergy photons of 18 F-NaF. 5,6 Recently, a prospective pilot study showed the feasibility of performing a single PET/CT scan using a combined administration of 18 F/ 18 F-FDG for adult cancer detection. 14…”

Section: Radiopharmaceuticalsmentioning

confidence: 99%

“…Generally, SPECT studies are superior to planar images and particularly useful in the evaluation of back pain. 5,6 Combining the functional imaging of SPECT with the anatomical imaging of CT can further improve diagnostic accuracy and localization. Recently, SPECT/CT imaging systems have become available and are rapidly emerging as a useful technique in musculoskeletal imaging.…”

Section: Bone Scintigraphy Techniquementioning

confidence: 99%

“…Generally, a bone scan is obtained after aspiration to detect any associated osteomyelitis. 5,29 Legg-Calvé -Perthes Disease Legg-Calvé-Perthes disease is an idiopathic ischemic necrosis of the femoral head in children. This disorder is most commonly seen in children between 5 and 8 years of age.…”

Section: Septic Arthritis and Transient Synovitismentioning

confidence: 99%

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Nuclear Medicine Imaging of the Pediatric Musculoskeletal System

Shammas

2009

Semin Musculoskelet Radiol

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Bone scintigraphy is a common pediatric nuclear medicine procedure and plays a significant role in the diagnosis of skeletal infection, trauma, and benign and malignant bone tumors. There is a complementary role for bone scintigraphy in the assessment of a child with suspected nonaccidental injury. High-quality images require careful attention to technique and positioning in children. Additional techniques such as magnification and single-photon emission computed tomography (SPECT) can be used for special indications and localization. Combined functional and anatomic imaging using SPECT/computed tomography (CT) imaging systems can improve diagnostic accuracy. Positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (FDG) is being applied with increasing frequency in the evaluation of children with malignancy. To interpret (18)F-FDG PET appropriately, it is essential to know the normal physiological distribution. Using combined (18)F-FDG PET/CT improves specificity and localization. This article reviews the common indications for bone scintigraphy and (18)F-FDG PET/CT in benign and malignant pediatric musculoskeletal disease.

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Section: Benign Etiologymentioning

confidence: 96%

Section: Radiopharmaceuticalsmentioning

confidence: 99%

Section: Bone Scintigraphy Techniquementioning

confidence: 99%

Section: Septic Arthritis and Transient Synovitismentioning

confidence: 99%

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Nuclear Medicine Imaging of the Pediatric Musculoskeletal System

Shammas

2009

Semin Musculoskelet Radiol

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“…It is a sensitive method to detect alteration of bone metabolism of any cause and should be correlated with the patient's clinical history and other test results because of its low specificity (12)(13)(14). Hybrid imaging with CT, such as SPECT/CT and PET/CT, improves specificity and diagnostic accuracy.…”

Section: Value Of Pediatric Nuclear Medicinementioning

confidence: 99%

Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 1—Statement of the Issue and a Review of Available Resources

et al. 2015

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The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 and consists of 13 international organizations with direct involvement in nuclear medicine. The underlying objectives of the NMGI were to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. For its first project, the NMGI decided to consider the issues involved in the standardization of administered activities in pediatric nuclear medicine. This article presents part 1 of the final report of this initial project of the NMGI. It provides a review of the value of pediatric nuclear medicine, the current understanding of the carcinogenic risk of radiation as it pertains to the administration of radiopharmaceuticals in children, and the application of dosimetric models in children. A listing of pertinent educational and reference resources available in print and online is also provided. The forthcoming part 2 report will discuss current standards for administered activities in children and adolescents that have been developed by various organizations and an evaluation of the current practice of pediatric nuclear medicine specifically with regard to administered activities as determined by an international survey of nuclear medicine clinics and centers. Lastly, the part 2 report will recommend a path forward toward global standardization of the administration of radiopharmaceuticals in children. Int he summer of 2012, several international organizations directly involved in the practice and science of nuclear medicine decided to engage in a project of common interest for the betterment of the field worldwide. The underlying objectives were to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. This endeavor was named the Nuclear Medicine Global Initiative (NMGI) and includes societies from various countries as well as several multinational organizations in the field of nuclear medicine (Table 1).The 13 involved organizations determined that there would be great benefit to the field of nuclear medicine at large in developing a forum in which discussions of important topics of interest could be held. The group recognized that nuclear medicine is a relatively small medical specialty and that professional organizations in the specialty are challenged by limited time and resources. The NMGI is an opportunity for these professional organizations to leverage their strengths and expertise through international cooperation in areas of mutual interest and marks the first time international professional societies of nuclear medicine have worked together to achieve a specific goal.It was decided that the group would co...

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123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma

Bleeker¹,

Tytgat

Adam

et al. 2015

Cochrane Database of Systematic Reviews

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Background Neuroblastoma is an embryonic tumour of childhood that originates in the neural crest. It is the second most common extracranial malignant solid tumour of childhood. Neuroblastoma cells have the unique capacity to accumulate Iodine‐123‐metaiodobenzylguanidine (¹²³I‐MIBG), which can be used for imaging the tumour. Moreover, ¹²³I‐MIBG scintigraphy is not only important for the diagnosis of neuroblastoma, but also for staging and localization of skeletal lesions. If these are present, MIBG follow‐up scans are used to assess the patient's response to therapy. However, the sensitivity and specificity of ¹²³I‐MIBG scintigraphy to detect neuroblastoma varies according to the literature. Prognosis, treatment and response to therapy of patients with neuroblastoma are currently based on extension scoring of ¹²³I‐MIBG scans. Due to its clinical use and importance, it is necessary to determine the exact diagnostic accuracy of ¹²³I‐MIBG scintigraphy. In case the tumour is not MIBG avid, fluorine‐18‐fluorodeoxy‐glucose ( 18 F‐FDG) positron emission tomography (PET) is often used and the diagnostic accuracy of this test should also be assessed. Objectives Primary objectives: 1.1 To determine the diagnostic accuracy of ¹²³I‐MIBG (single photon emission computed tomography (SPECT), with or without computed tomography (CT)) scintigraphy for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old. 1.2 To determine the diagnostic accuracy of negative ¹²³I‐MIBG scintigraphy in combination with 18 F‐FDG‐PET(‐CT) imaging for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old, i.e. an add‐on test. Secondary objectives: 2.1 To determine the diagnostic accuracy of 18 F‐FDG‐PET(‐CT) imaging for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old. 2.2 To compare the diagnostic accuracy of ¹²³I‐MIBG (SPECT‐CT) and 18 F‐FDG‐PET(‐CT) imaging for detecting a neuroblastoma and its metastases at first diagnosis or at recurrence in children from 0 to 18 years old. This was performed within and between included studies. ¹²³I‐MIBG (SPECT‐CT) scintigraphy was the comparator test in this case. Search methods We searched the databases of MEDLINE/PubMed (1945 to 11 September 2012) and EMBASE/Ovid (1980 to 11 September 2012) for potentially relevant articles. Also we checked the reference lists of relevant articles and review articles, scanned conference proceedings and searched for unpublished studies by contacting researchers involved in this area. Selection criteria We included studies of a cross‐sectional design or cases series of prove...

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Pediatric Musculoskeletal Nuclear Medicine

Abstract: This article reviews the current role of nuclear medicine in common benign and malignant pediatric musculoskeletal conditions and discusses future applications.

Cited by 11 publications

References 44 publications

Nuclear Medicine Imaging of the Pediatric Musculoskeletal System

Nuclear Medicine Imaging of the Pediatric Musculoskeletal System

Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 1—Statement of the Issue and a Review of Available Resources

123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma

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