Pediatric multiple sclerosis and its familial recurrence: A population based study (1999–2017)

Eskandarieh, Sharareh; Sahraiain, M.A.; Molazadeh, Negar; Moghadasi, Abdorreza Naser

doi:10.1016/j.msard.2019.101377

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…The prevalence of pediatric MS in Europe and the United States was much higher than that in Asia, which is concordant with the whole MS prevalence [3,8]. In Asia Pacific region, it was found to be variable, ranged from 0.69 to 26.2 per 100,000 persons [10,11]. Our prevalence of pediatric MS (0.55-0.63/100,000 in age < 20 years, 2016-2020) was comparable to that in Japan (0.69/100,000 in age ≤ 15 years, 2005-2007) and Taiwan (0.91-1.35/100,000 in age < 20 years, 2001-2015) [10,12].…”

Section: Rarity Of Pediatric Adssupporting

confidence: 71%

Epidemiology and Healthcare Utilization in Pediatric Multiple Sclerosis and Neuromyelitis Optica: A Nationwide Population-Based Study in South Korea (2016–2020)

Woo,

Hwang,

Choi

et al. 2024

Children

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Pediatric multiple sclerosis (MS) and neuromyelitis optica (NMO) are rare acquired demyelinating syndrome with limited epidemiological data available, particularly in non-Western setting. This study aimed to demonstrate the epidemiology of pediatric MS and NMO in South Korea and to analyze of healthcare utilization and economic burden associated with these conditions. Using a nationwide population-based database from the Korean Health Insurance Review and Assessment Service database, we identified pediatric cases (age < 20 years) of MS and NMO from 2016 to 2020. We analyzed incidence, prevalence, healthcare utilization and medical costs. The study found low age-standardized incidence and prevalence rates for pediatric MS and NMO in South Korea. There was a marked disparity in healthcare utilization between urban and rural areas. Most healthcare interactions occurred in tertiary hospitals in urban settings, particularly in Seoul. The study also highlighted the substantial economic burden associated with the management of rare diseases, with annual variability in medical costs. Pediatric MS and NMO are extremely rare in South Korea, with significant regional disparity in healthcare utilization. The findings emphasize the need for targeted healthcare policies to improve access and reduce disparities, particularly for chronic and rare diseases requiring specialized care.

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Section: Rarity Of Pediatric Adssupporting

confidence: 71%

Epidemiology and Healthcare Utilization in Pediatric Multiple Sclerosis and Neuromyelitis Optica: A Nationwide Population-Based Study in South Korea (2016–2020)

Woo,

Hwang,

Choi

et al. 2024

Children

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“…the disordered activation of the immune system 1,11,12 . Regarding genetic factors, there is until 14.9% cases with positive familial history of MS 13 . When both parents are diagnosed with MS, their child has around a 30% risk of developing the disease, even early.…”

Section: Discussionmentioning

confidence: 99%

“…When both parents are diagnosed with MS, their child has around a 30% risk of developing the disease, even early. On the other hand, if one of the parents is diagnosed with MS, this risk is between 2% and 5%, the risk being higher in the case of a daughter of a mother with MS 13 . There is a higher prevalence in black children compared to Caucasian children, in addition to a similar distribution for both sexes in ages younger than 10-12 years, and female predominance in older ages 14 .…”

Section: Discussionmentioning

confidence: 99%

Desafios No Manejo Da Esclerose Múltipla Precoce Em Uma Criança Com 5 Anos De Idade: Relato De Caso

Ribeiro¹,

Pimentel²,

Nascimento³

et al. 2022

RECIMA21

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Este estudo relata o caso de uma criança com Esclerose Múltipla precoce. É uma doença inflamatória do Sistema Nervoso Central, mais comum em adultos, considerada muito rara na primeira década de vida. O paciente tinha 5 anos quando sofreu ataques agudos de ataxia e paparese. A ressonância magnética do encéfalo mostrou lesões compatíveis com a doença, embora o líquido cefalorraquidiano não tenha detectado alterações típicas. Houve recuperação dos surtos e dificuldades para utilizar o tratamento imunomodulador. Isso reflete o quanto o diagnóstico e manejo em crianças e adolescentes é mais difícil, pois apresentam sintomas inespecíficos que abrem um leque de diferentes diagnósticos diferenciais. Portanto, o relato destaca as diferenças entre a esclerose múltipla em adultos e crianças e as dificuldades nessa população específica.

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“…Amongst the siblings, sister-sister, sister-brother, and brother-brother relation are, respectively, more prevalent [29,34]. Evidently, after rst-degree relatives, third-degree relatives have more chance for the development of MS [13,18,34].…”

Section: Discussionmentioning

confidence: 99%

The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

Ehtesham

Rafie

Mosallaei

2021

Preprint

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Background: Considering that familial multiple sclerosis (FMS) can reveal the extent to which genetic and environmental factors each involve in the etiopathogenesis of the disease, we performed an updated meta-analysis of the worldwide prevalence of FMS by addition of recent publications. Methods: A search in PubMed, Scopus, the ISI Web of Science, and Google Scholar up to 20 December 2020 was done. The inclusion criteria were based on the CoCoPop approach (condition, context, and population). The qualified studies entered the process of the meta-analysis by using comprehensive meta-analysis ver. 2 software.Results: The pooled prevalence of MS in relatives of 16179 FMS cases was estimated to be 11.8% (95% CI: 10.7-13) based on a random-effects model. The pooled mean age of disease onset in adult probands was calculated to be 28.7 years (95% CI: 27.2± 30.2). In 13 studies that reported the data of FMS in pediatrics (n=6636) and adults (n=877), the FMS prevalence was 10.8% (95% CI: 8.1-14.2) and 15.5% (95% CI: 13.8-17.4), respectively. Considering the data of 9 studies, the prevalence of FMS in males (n=5243) and females (n=11503) patients was calculated to be 13.7% (95% CI: 10.1-18.2) and 15.4% (95% CI: 10.3-22.4), respectively. The odds ratio of male/female in FMS cases was not statistically significant (OR= 0.9; 95% CI: 0.6-1.2, P=0.55). Subgroup analysis demonstrated a significant difference in the prevalence of FMS between the geographical areas (P= 0.007). The meta-regression model for FMS prevalence was significantly lower in terms of higher latitude (P< 0.001) and increased MS prevalence (P< 0.001). In contrast, meta-regression based on prevalence day was not statistically significant (P=0.29).Conclusions: The prevalence of FMS is more in the pediatric group than that of adults, is distinct between geographical areas, and diminishes with the increment of MS prevalence and latitude. Also, the symptoms initiate relatively at lower ages in FMS cases. By contrast with multifactorial diseases, our analysis unveiled that the prevalence of FMS was not more prevalent in men than women and the risk of MS development in relatives was not more when the affected proband was male.

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Pediatric multiple sclerosis and its familial recurrence: A population based study (1999–2017)

Cited by 10 publications

References 29 publications

Epidemiology and Healthcare Utilization in Pediatric Multiple Sclerosis and Neuromyelitis Optica: A Nationwide Population-Based Study in South Korea (2016–2020)

Epidemiology and Healthcare Utilization in Pediatric Multiple Sclerosis and Neuromyelitis Optica: A Nationwide Population-Based Study in South Korea (2016–2020)

Desafios No Manejo Da Esclerose Múltipla Precoce Em Uma Criança Com 5 Anos De Idade: Relato De Caso

The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

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