Pediatric Multiple Sclerosis

Kornbluh, Alexandra B.; Kahn, Ilana

doi:10.1016/j.spen.2023.101054

Cited by 4 publications

(3 citation statements)

References 74 publications

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“…It presents with brain and spinal cord lesions that can result in physical and cognitive impairments [3,4]. While typically diagnosed in adults (adult-onset MS or AOMS), pediatric-onset multiple sclerosis (POMS), referring to the manifestation of MS in individuals under 18 years old, involves from 3% to 10% of the entire MS population [5][6][7]. The clinical presentation of POMS varies with age [8].…”

Section: Introductionmentioning

confidence: 99%

Parental Experiences in Pediatric Multiple Sclerosis: Insights from Quantitative Research

Tarantino,

Proietti Checchi,

Papetti

et al. 2024

Children

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Multiple sclerosis (MS) is a chronic and unpredictable inflammatory disease impacting the central nervous system. The disabling nature of this disease is not limited to only physical symptoms. MS, even at a pediatric age, often includes cognitive impairment, fatigue, and psychological issues, affecting education and social life, causing emotional distress, and reducing quality of life. Despite the paucity of quantitative data in the existing literature, our review demonstrates that the impact of pediatric MS extends beyond the patients themselves, affecting their parents as well. There is evidence suggesting that having a child with MS may be associated with a reduction in the parental quality of life, even in families of MS patients with low or no disability and without clinical relapses. Moreover, an increased risk of parents’ mental illness has been described, particularly in mothers, leading to a heightened utilization of mental health services. Research data show that inadequate information about MS may impact parents’ anxiety and their sense of competence. Since parents’ involvement has been found to also play a role in their child’s adherence to treatment, special attention should be paid to parental psychological health. Additional research exploring family adaptation to their children’s illness is required.

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Section: Introductionmentioning

confidence: 99%

Parental Experiences in Pediatric Multiple Sclerosis: Insights from Quantitative Research

Tarantino,

Proietti Checchi,

Papetti

et al. 2024

Children

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“…Multiple sclerosis (MS) is a chronic neurological disease that mainly affects adults, but which can also manifest itself in children, although it is less common in this age group (Kornbluh and Kahn, 2023). This disease is an immune-mediated condition, being characterized by inflammation and destruction of myelin, the protective layer that surrounds nerve fibers in the central nervous system (CNS) (Teleanu et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging characterization of multiple sclerosis lesions in pediatric patients: an exploratory radiomics approach

Faustino,

Lopes,

Jantarada

et al. 2024

Front. Neurosci.

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IntroductionMultiple sclerosis (MS), a chronic inflammatory immune-mediated disease of the central nervous system (CNS), is a common condition in young adults, but it can also affect children. The aim of this study was to construct radiomic models of lesions based on magnetic resonance imaging (MRI, T2-weighted-Fluid-Attenuated Inversion Recovery), to understand the correlation between extracted radiomic features, brain and lesion volumetry, demographic, clinical and laboratorial data.MethodsThe neuroimaging data extracted from eleven scans of pediatric MS patients were analyzed. A total of 60 radiomic features based on MR T2-FLAIR images were extracted and used to calculate gray level co-occurrence matrix (GLCM). The principal component analysis and ROC analysis were performed to select the radiomic features, respectively. The realized classification task by the logistic regression models was performed according to these radiomic features.ResultsTen most relevant features were selected from data extracted. The logistic regression applied to T2-FLAIR radiomic features revealed significant predictor for multiple sclerosis (MS) lesion detection. Only the variable “contrast” was statistically significant, indicating that only this variable played a significant role in the model. This approach enhances the classification of lesions from normal tissue.Discussion and conclusionOur exploratory results suggest that the radiomic models based on MR imaging (T2-FLAIR) may have a potential contribution to characterization of brain tissues and classification of lesions in pediatric MS.

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“…The International Pediatric Multiple Sclerosis Study Group (IPMSSG) published in 2007 the first diagnostic criteria for POMS, and these were revised in 2012. These criteria referred to the 2010 McDonald criteria for the demonstration of dissemination in time and space [8,9].…”

Section: Introductionmentioning

confidence: 99%

Lower Urinary Tract Dysfunction in Pediatric Patients with Multiple Sclerosis: Diagnostic and Management Concerns

Sollini,

Pellegrino,

Barone

et al. 2024

Children

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Background: Multiple sclerosis (MS) is increasing in the pediatric population and, as in adults, symptoms vary among patients. In children the first manifestations can sometimes overlap with acute neurological symptoms. Urological symptoms have not been much studied in childhood. We shared our experience with MS urological manifestation in children. Methods: This article is a retrospective evaluation of all children with MS, according to the Krupp criteria, who also present with urological symptoms. We collected demographic and clinical history, the MR localization of demyelinating lesions, urological symptoms, and exams. Results: We report on six MS pediatric cases with urological manifestation. Urinary symptoms, characterized by urinary incontinence in five patients and urinary retention in one patient, appeared in a different time frame from MS diagnosis. Urodynamic exams showed both overactive and underactive bladder patterns. Treatment was defined according to lower urinary tract dysfunction, using clean intermittent catheterization, oxybutynin, and intradetrusor Onabotulinum Toxin-A injection. A low acceptance rate of invasive evaluation and urological management was observed. Conclusions: The MS diagnosis was traumatic for all our patients. We believe it is important to address urological care in young people from the time of diagnosis for prompt management; it could be useful to include a pediatric urologist in multidisciplinary teams.

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Pediatric Multiple Sclerosis

Cited by 4 publications

References 74 publications

Parental Experiences in Pediatric Multiple Sclerosis: Insights from Quantitative Research

Parental Experiences in Pediatric Multiple Sclerosis: Insights from Quantitative Research

Neuroimaging characterization of multiple sclerosis lesions in pediatric patients: an exploratory radiomics approach

Lower Urinary Tract Dysfunction in Pediatric Patients with Multiple Sclerosis: Diagnostic and Management Concerns

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