Pediatric middle ear infections and gastroesophageal reflux

Karkos, Petros D.; Assimakopoulos, D.; Issing, W. J.

doi:10.1016/j.ijporl.2004.07.019

Cited by 13 publications

(11 citation statements)

References 18 publications

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“…The possible relationship between GER and OME has been studied over recent years. GER is thought to cause inflammation of the nasopharynx, dysfunction of the eustachian tube, and impairment of the mucociliary clearance, thus leading to increase in the incidence of OME [3,9,10].…”

Section: Discussionmentioning

confidence: 99%

“…Esophageal pH monitoring, endoscopy and biopsy, nuclear scan, and empiric therapy trials are used for the diagnosis of GER [3]. The measurement of pepsin/pepsinogen in MEE has recently been used in studies to detect GER in children with OME.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis is thought to be multifactorial. Infection, obstruction of the eustachian tubes, anatomical factors, impaired immunologic status, allergy, familial predisposition, male sex, wrong methods of feeding, and environmental factors have been suggested to play roles in the etiopathogenesis of OME [3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of gastric pepsinogen in middle ear fluid of children with glue ear

Toros¹,

Toros²,

Özel

et al. 2010

Acta Oto-Laryngologica

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Investigation of gastric pepsinogen in middle ear fluid of children with glue ear

Toros¹,

Toros²,

Özel

et al. 2010

Acta Oto-Laryngologica

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“…However, clinical studies in children investigating the association of RAOM with GERD are scarce [20,[22][23][24][25][26][27] and case-control studies do not really exist. The present study used the dual-probe 24-h pH-monitoring that is considered to be the ''gold standard'' examination for diagnosis of gastroesophageal reflux [5,[28][29][30][31].…”

Section: Case Sexmentioning

confidence: 99%

Recurrent acute otitis media and gastroesophageal reflux disease in children. Is there an association?

Kotsis

Nikolopoulos

Yiotakis

et al. 2009

International Journal of Pediatric Otorhinolaryngology

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“…29 Nevertheless, the relationship between otitis and GERD is still very controversial. 30 It is also evident that acidification of the terminal esophagus should induce the production of some type of mediator able to affect more distant tissues. This can be observed, for instance, in…”

Section: Resultsmentioning

confidence: 99%

pH nasofaríngeo e refluxo gastroesofágico em crianças com doença respiratória crônica

Junqueira

Penna²

2007

J. Pediatr. (Rio J.)

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Objectives: The aim of this case-control study was to evaluate the nasopharyngeal pH (NasopH) in children with normal or abnormal pH-metry in two groups of patients: 1) children presenting gastroenterological symptoms; and 2) children with chronic respiratory symptoms. Methods:From February 2004 to January 2005, all consecutive patients referred for 24-hour pH-metry and in whom gastroesophageal reflux disease was suspected were enrolled in a prospective study. They were assigned to four groups: gastroenterological symptoms with normal (A) or abnormal (B) pH-metries (GG), and chronic respiratory symptoms with normal (C) or abnormal (D) pH-metries (RG). NasopH was measured for 5 minutes, before the 24-hour test was performed.Results: Thirty-eight pH-metry tests were included (20 in the RG and 18 in the GG). Abnormal pH-metry results were observed in 11 patients in the GG and in 12 in the RG. NasopH means were 6.3273 and 5.6917, respectively (p < 0.0001). Average nasopharyngeal pH was 5.6917 among the 12 RG patients with abnormal pH-metry results and 6.5000 among the remaining eight patients with normal test results (p = 0.0006). Analysis of the RG with a receiver operating characteristic (ROC) curve showed pH of 5.8 as cutoff point (sensitivity of 91.7% and specificity of 87.5%).The area below the ROC curve was 0.870. Conclusions:Nasopharyngeal pH is significantly lower among patients in the RG presenting abnormal pH-metry results. A 5.8 NasopH has good sensitivity and specificity and can be used as a screening test in patients with chronic respiratory diseases to select those for whom conventional 24-hour pH-metry is indicated.J Pediatr (Rio J). 2007;83(3):225-232: Gastroesophageal reflux/complications/diagnosis, child, evaluation studies, nasopharynx, esophageal pH monitoring.

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Pediatric middle ear infections and gastroesophageal reflux

Cited by 13 publications

References 18 publications

Investigation of gastric pepsinogen in middle ear fluid of children with glue ear

Investigation of gastric pepsinogen in middle ear fluid of children with glue ear

Recurrent acute otitis media and gastroesophageal reflux disease in children. Is there an association?

pH nasofaríngeo e refluxo gastroesofágico em crianças com doença respiratória crônica

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