Pediatric Metarrhizium anisopliae keratitis

Motley, William W.; Melson, Andrew T.; Mortensen, Joel E.

doi:10.1016/j.jaapos.2010.12.003

Cited by 19 publications

(14 citation statements)

References 12 publications

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“…A third case of ocular involvement was reported in a 52-year-old Australian woman who developed sclerokeratitis [6]. She did not respond to multidrug therapy which include natamycin eyes drops, topical and systemic voriconazole and eventually required a therapeutic penetrating keratoplasty. The fourth case was reported in a 12-year-old girl who responded well to topical antifungal therapy [5]. To our knowledge, this is the first reported case of fungal keratitis caused by a member of the M. anisopliae complex in Canada and only the fifth ocular case worldwide.…”

Section: Discussionmentioning

confidence: 76%

“…M. anisopliae has been used as a biological control agent of insects in many countries globally [5]. It was not believed to adversely affect humans because it is unable to grow at human body temperature [6]; however, it has been recently reported as pathogenic to humans. There have been four reported cases of M. anisopliae causing ocular infection [5], [6], [7], [8] The first report of mycotic keratitis caused by M. anisopliae was in 1997, in an 18-year-old Colombian man [7]. Another case was reported 4 years later in a healthy 36-year-old female in the United States [8]. Both patients were treated successfully with natamycin eye drops.…”

Section: Discussionmentioning

confidence: 99%

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Fungal keratitis caused by Metarhizium anisopliae complex

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Kus

Tsui

et al. 2017

Medical Mycology Case Reports

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PurposeTo report a case of fungal keratitis caused by Metarhizium anisopliae complexMethodsCase reportResultsOur patient presented with a central corneal infiltrate. Fungal culture yielded a Metarhizium species. She was started on antifungal agents with no significant improvement. A therapeutic corneal transplant was performed after perforation. At two years follow up, she was free of infection.ConclusionMetarhizium anisopliae is a very rare cause of keratitis. Although previous reported cases showed clinical improvement with antifungal agents, this case required surgical treatment to control the infection.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Fungal keratitis caused by Metarhizium anisopliae complex

Showail

Kus

Tsui

et al. 2017

Medical Mycology Case Reports

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“…Although some Lagenidium sp. infections have been reported in mammals, including dogs (14) and humans (15), these cases may be categorized, respectively, as examples of taxonomic misclassification (16) or rare keratitis caused by an invertebrate pathogen, similar to the cases caused by the entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana (17,18). Because L. giganteum consistently behaves as a virulent pathogen of certain mosquito species, it has been registered with the U.S. Environmental Protection Agency and several states, including California and Florida, for use as a mosquito control tool (1).…”

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confidence: 99%

Transcriptome Analysis of the Entomopathogenic Oomycete Lagenidium giganteum Reveals Putative Virulence Factors

Velasquez

Abiff

Fins

et al. 2014

Appl Environ Microbiol

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A combination of 454 pyrosequencing and Sanger sequencing was used to sample and characterize the transcriptome of the entomopathogenic oomycete Lagenidium giganteum. More than 50,000 high-throughput reads were annotated through homology searches. Several selected reads served as seeds for the amplification and sequencing of full-length transcripts. Phylogenetic analyses inferred from full-length cellulose synthase alignments revealed that L giganteum is nested within the peronosporalean galaxy and as such appears to have evolved from a phytopathogenic ancestor. In agreement with the phylogeny reconstructions, full-length L. giganteum oomycete effector orthologs, corresponding to the cellulose-binding elicitor lectin (CBEL), crinkler (CRN), and elicitin proteins, were characterized by domain organizations similar to those of pathogenicity factors of plantpathogenic oomycetes. Importantly, the L. giganteum effectors provide a basis for detailing the roles of canonical CRN, CBEL, and elicitin proteins in the infectious process of an oomycete known principally as an animal pathogen. Finally, phylogenetic analyses and genome mining identified members of glycoside hydrolase family 5 subfamily 27 (GH5_27) as putative virulence factors active on the host insect cuticle, based in part on the fact that GH5_27 genes are shared by entomopathogenic oomycetes and fungi but are underrepresented in nonentomopathogenic genomes. The genomic resources gathered from the L. giganteum transcriptome analysis strongly suggest that filamentous entomopathogens (oomycetes and fungi) exhibit convergent evolution: they have evolved independently from plant-associated microbes, have retained genes indicative of plant associations, and may share similar cores of virulence factors, such as GH5_27 enzymes, that are absent from the genomes of their plant-pathogenic relatives.

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“…2 Our search of the English-language literature yielded fewer than 10 reported cases of Metarhizium anisopliae ocular infection worldwide. [3][4][5][6][7][8][9] Mode of transmission typically involves agricultural exposure, with a history of vegetal trauma or soft contact lens wear. Although fungal keratitis is thought to be more common in tropical regions, 1 most published cases of Metarhizium anisopliae keratitis have arisen in temperate or extratropical climates, including Japan, 5 France, 6,7 the United States, 8 and Australia.…”

Section: Diagnosis and Discussionmentioning

confidence: 99%

A 24-year-old contact lens wearer with unilateral vision loss requiring penetrating keratoplasty

2019

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A 24-year-old myopic woman from rural Victoria who wore extended-wear soft contact lenses presented at Alfred Health, Melbourne, Australia, with a 2-week history of left eye irritation, redness, photophobia, and reduced visual acuity. She denied sleeping while wearing lenses, trauma, or agricultural exposure. She had been treated with topical ciprofloxacin 0.3% drops without improvement. There was a history of travel to Vietnam but only to coastal city centers. Initial symptoms developed in Australia prior to traveling to Vietnam, where they became progressively worse.

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Pediatric Metarrhizium anisopliae keratitis

Cited by 19 publications

References 12 publications

Fungal keratitis caused by Metarhizium anisopliae complex

Fungal keratitis caused by Metarhizium anisopliae complex

Transcriptome Analysis of the Entomopathogenic Oomycete Lagenidium giganteum Reveals Putative Virulence Factors

A 24-year-old contact lens wearer with unilateral vision loss requiring penetrating keratoplasty

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