Pediatric meningiomas in The Netherlands 1974–2010: a descriptive epidemiological case study

Thuijs, Nikki B.; Uitdehaag, Bernard M. J.; Ouwerkerk, W. J. R. van; Valk, Paul van der; Vandertop, W. Peter; Peerdeman, Saskia M.

doi:10.1007/s00381-012-1759-z

Cited by 54 publications

(47 citation statements)

References 27 publications

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“…There is also a higher frequency of WHO grade II and WHO grade III tumors in the <20 year age group than seen in older age groups and they are more frequently multiple. [5,6,23,26,30,31,33] Ionizing radiation is a risk factor for both pediatric and adult patients because of the long latency period involved in the development of post-radiation brain tumors; other possible etiological factors such as cranial trauma or viruses have not been conclusively shown to have a role in the pathogenesis of meningiomas [5,6,19,23,25,26,30,31,33]. Most of the studies in the literature focus on the clinical and histological characteristics of meningiomas in patients <20 years of age ( Table 6).…”

Section: Discussionmentioning

confidence: 99%

“…The average age in those studies was between 10 and 15 years, [5,6,18,23,26,30,31,33] while the average age in our patient cohort was 25 years. It is possible that this is a reflection of the referral pattern to our practice and the representation of a more adult population accounted for this difference.…”

Section: Genetic Predisposition To Intracranial Meningiomamentioning

confidence: 99%

“…This association is more pronounced in individuals <20 years of age. [5][6][7]23,26,30,31,33]. Other genetic syndromes that predispose to intracranial meningioma formation include MA, Gorlin's syndrome, and Down's Syndrome [6].…”

Section: Genetic Predisposition To Intracranial Meningiomamentioning

confidence: 99%

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Intracranial meningiomas in individuals under the age of 30; Analysis of risk factors, histopathology, and recurrence rate

Prabhu¹,

Perry²,

Melian³

et al. 2014

Neurosci Discov

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Background: Intracranial meningiomas are rare in individuals under age 30 years. The purpose of this study was to analyze the demographics and clinical features of intracranial meningiomas in individuals under age 30 years. Methods: A retrospective analysis of clinical, radiographic, and pathology data of patients under age 30 years who presented with an intracranial meningioma was performed. Results: Thirty five patients met the criteria. Mean age was 25 years, 11 were male and 24 female. Five patients had previous radiation exposure. The presenting symptom was headache in 16 patients (45.7%) and seizure in 9 (25.7%). Cranial base tumors comprised 74%; 26% were supratentorial. Simpson grade 1 or 2 resection was achieved in 16 patients (48.5%); grade 3 or 4 resection was achieved in 17 patients (51.5%). Tumor pathologic grade was WHO grade I in 27 (77.1%), grade II in 6 (17.1%) and grade III in 2 patients (5.7%). Postoperative radiation therapy for tumor progression was administered in 13 patients. Radiographic follow-up was available in 26 patients at an average of 6.1 years after surgery; of these, 14 had no recurrence or progression of residual tumor while 12 had recurrence or progression. Recurrence was more common in patients with WHO grade II and III tumors and radiation-induced meningiomas. Recurrent tumors tended to have a higher WHO grade. Conclusion: In this group of intracranial meningiomas in individuals <30 years, ionizing radiation was a risk factor and tumors were more common in females. A higher percentage of WHO grade II and III tumors at presentation and recurrence was noted. Recurrent tumors were more common in patients with higher WHO grade and in radiation-induced meningiomas.

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Section: Discussionmentioning

confidence: 99%

Section: Genetic Predisposition To Intracranial Meningiomamentioning

confidence: 99%

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Intracranial meningiomas in individuals under the age of 30; Analysis of risk factors, histopathology, and recurrence rate

Prabhu¹,

Perry²,

Melian³

et al. 2014

Neurosci Discov

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“…La présentation clinique de la NF2 chez l'enfant est particulière. L'âge médian de découverte de la maladie est de 13 ans, la majorité des patients étant âgée entre 12 et 18 ans [2,8,9]. Les premiers symptômes ne sont pas ceux liés à des schwannomes vestibulaires, mais plutôt à l'existence d'un méningiome, ou d'une tumeur spinale ou à la présence de schwannomes cutanés [3,8].…”

Section: Discussionunclassified

Neurofibromatose de type 2 précoce et hamartome rétinien congénital

Hérissé

Poirée

Boyer

et al. 2015

Archives de Pédiatrie

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“…[5] An epidemiological study from the Netherlands showed that the overall meningioma incidence in children and adolescents is approximately 1: 1,700.000/year. [15] Due to the rarity of these lesions, large prospective studies are not available. By contrast, there are a relatively large number of single-center retrospective studies, compromising patients, within the literature.…”

Section: Introductionmentioning

confidence: 99%

Surgical Resection of Pediatric Skull Base Meningiomas

Burkhardt¹,

Krayenbühl²,

Bernays³

et al. 2012

J Neurol Surg A Cent Eur Neurosurg

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PURPOSE: Meningiomas in children are rare, especially those located at the skull base. In this study, we report our experience of meningioma surgery in the pediatric population and compare our findings of skull base (SB) versus non-skull base (NSB) meningiomas. METHODS: From our database of 724 surgically treated meningioma patients at the University Hospital, Zurich between 1995 and 2010, 12 patients under 18 years of age were identified. Data for those patients was retrospectively collected through chart review. A descriptive comparison between SB and NSB meningiomas was undertaken to determine statistical significance. RESULTS: In all 12 children (seven males, five females; mean age 12.2 ± 4.3 years), surgical removal of the meningioma was performed microsurgically with a mean follow-up of 53 months (range 12-137 months). Of the 12 tumors, six were located in the SB and six in the NSB. Comparing SB to NSB lesions, the mean age was 11 ± 3.8 versus 14 ± 4.6 years, male/female gender distribution was 5:1 compared to 1:5, mean tumor size was 7.5 ± 6.2 versus 26 ± 15.8 cm(2) (p = 0.03), and mean surgery time was 347 versus 214 min. While WHO grade was similar for both groups, the Simpson grade revealed more extensive resection for NSB meningiomas. The Glasgow Outcome Scale at last follow-up was favorable for both groups. CONCLUSIONS: Meningioma surgery was safe with favorable outcomes. SB meningiomas were significantly smaller in size, were less likely to undergo complete resection, and had a predilection for younger, male patients. Surgical Resection of Pediatric Skull Base Meningiomas Keywords:Pediatric meningiomas, skull base meningioma, neurosurgery, resection 2 AbstractPurpose Meningiomas in children are rare, especially those located at the skull base. In this study, we report our experience of meningioma surgery in the pediatric population and compare our findings of skull base (SB) versus non-skull base (NSB) meningiomas.Methods From our database of 724 surgically-treated meningioma patients at the University Hospital, Zurich between 1995 and 2010, 12 patients under 18 years of age were identified.Data for those patients was retrospectively collected through chart review. A descriptive comparison betweent SB and NSB meningiomas was undertaken to determine statistical significance.Results In all 12 children (7 males, 5 females; mean age 12.2 ± 4.3 years) surgical removal of the meningioma was performed microsurgically with a mean follow-up of 53 months (range 12-137 months). Of the 12 tumors, 6 were located in the SB and 6 in the NSB. Comparing SB to NSB lesions, the mean age was 11 ± 3.8 years versus 14 ± 4.6 years; male:female gender distribution was 5:1 compared to 1:5, mean tumor size was 7.5 ± 6.2 cm 2 versus 26 ± 15.8 cm 2 (p=0.03) and mean surgery time was 347 minutes versus 214 minutes. Whilst WHO grade was similar for both groups, the Simpson grade revealed more extensive resection for NSB meningiomas. The Glasgow outcome scale at last follow up was favorable for both groups.Conclusions...

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Pediatric meningiomas in The Netherlands 1974–2010: a descriptive epidemiological case study

Cited by 54 publications

References 27 publications

Intracranial meningiomas in individuals under the age of 30; Analysis of risk factors, histopathology, and recurrence rate

Intracranial meningiomas in individuals under the age of 30; Analysis of risk factors, histopathology, and recurrence rate

Neurofibromatose de type 2 précoce et hamartome rétinien congénital

Surgical Resection of Pediatric Skull Base Meningiomas

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