Pediatric Melanoma: Risk Factor and Survival Analysis of the Surveillance, Epidemiology and End Results Database

Strouse, John J.; Fears, Thomas R.; Tucker, Margaret A.; Wayne, Alan S.

doi:10.1200/jco.2005.02.899

Cited by 328 publications

(332 citation statements)

References 21 publications

Supporting

Mentioning

301

Contrasting

Unclassified

Order By: Relevance

“…14,38,39 In comparisons between adult melanomas and pediatric melanomas, 36 the latter tumors were significantly thicker. Like what we observed in the current series, analyses of 2 national cancer databases 21,39 revealed that young adults and older teenagers had thinner lesions than children ages 1 to 14 years. When this factor was analyzed, thicker melanoma in children portended a significantly poor prognosis.…”

Section: Histologic Featuressupporting

confidence: 84%

“…26 In addition, in an epidemiologic study, 19 compared with younger children, the mortality rate among adolescents (ages 15-19 years) was roughly 8 to 18 times greater. It has been suggested that melanomas of the head and neck 21 and trunk 22 portend a poor prognosis, but did we not detect such an association.…”

Section: Demographic and Clinical Featurescontrasting

confidence: 83%

“…Nodular histology has been related to worse survival in children. 21 We detected a greater frequency of metastasis in this group, probably related to a greater Breslow thickness. However, this association was not significant in multivariate analysis or in the analysis of overall survival.…”

Section: Histologic Featuresmentioning

confidence: 49%

“…Previous surveys indicated a slight female predominance of melanoma among children. In 2 large studies, 20,21 male sex was associated with worse prognosis, but that finding was not confirmed by cancer registry studies 22,23 or epidemiologic studies. 19 We observed equal distributions for sex and prognosis.…”

Section: Demographic and Clinical Featuresmentioning

confidence: 96%

See 3 more Smart Citations

Prognostic factors for melanoma in children and adolescents

Paradela

Fonseca

Pita-Fernández

et al. 2010

Cancer

View full text Add to dashboard Cite

BACKGROUND: Cutaneous melanoma in childhood is rare; therefore, its prognostic factors and biologic behavior and the effectiveness of adjuvant diagnostic techniques in this group remain mostly unknown. METHODS: The authors conducted a retrospective, observational study on the prognostic significance of clinical and pathologic findings from 137 cutaneous and mucosal melanomas in patients aged <18 years that were reviewed by the pathology department of a large cancer center during the period from 1992 to 2006. RESULTS: Univariate analysis indicated that there was a significantly greater risk of metastases for patients who had previous nonmelanocytic malignancies, nodular histologic type, fusiform or spitzoid cytology, high Breslow thickness, vertical growth phase, high dermal mitotic activity, ulceration, and vascular invasion. Adjacent nevus and radial growth phase were associated with a better prognosis. Twelve patients (10.3%) died during follow-up. Decreased overall survival was related significantly to age >10 years, previous nonmelanocytic malignancy, high Breslow thickness, high Clark level, and the presence of metastases at diagnosis. All patients who died were aged !11 years, and 8 of those patients had metastases at diagnosis. In multivariate analysis, higher Breslow thickness predicted an increased risk of metastases, whereas age >10 years and the presence of metastases at diagnosis were associated with decreased survival. CONCLUSIONS: Similar to adults, the detection of metastases at diagnosis in children with melanoma was 1 of the main factors that influenced overall survival. Melanomas that were detected in children aged <11 years appeared to have a less aggressive behavior than those detected in adults. Cancer 2010;116:4334-44.

show abstract

Section: Histologic Featuressupporting

confidence: 84%

Section: Demographic and Clinical Featurescontrasting

confidence: 83%

Section: Histologic Featuresmentioning

confidence: 49%

Section: Demographic and Clinical Featuresmentioning

confidence: 96%

See 2 more Smart Citations

Prognostic factors for melanoma in children and adolescents

Paradela

Fonseca

Pita-Fernández

et al. 2010

Cancer

View full text Add to dashboard Cite

show abstract

“…The key primary tumor characteristics (eg, site of primary tumor, histology, stage at diagnosis, specific genetic mutations, tumor thickness, and level of invasion) of melanoma are often comparable between adults and adolescents. 16 Additionally, survival in both the adult and pediatric populations with melanoma is predicted by the tumor characteristics but not by age. 17 Therefore, extrapolation of efficacy data from adults with melanoma to adolescents with melanoma is acceptable if the systemic exposure to the drug achieved in adolescent patients is similar to that in adults.…”

Section: Extrapolation Of Pediatric Efficacy From Adult Studiesmentioning

confidence: 99%

Bridging Adult Experience to Pediatrics in Oncology Drug Development

Leong

Zhao

Reaman

et al. 2017

The Journal of Clinical Pharma

View full text Add to dashboard Cite

Pediatric drug development in the United States has grown under the current regulations made permanent by the Food and Drug Administration Safety and Innovation Act of 2012. Over 1200 pediatric studies have now been submitted to the US FDA, but there is still a high rate of failure to obtain pediatric labeling for the indication pursued. Pediatric oncology represents special problems in that the disease is most often dissimilar to any cancer found in the adult population. Therefore, the development of drug dosing in pediatric oncology patients represents a special challenge. Potential approaches to pediatric dosing in oncology patients include extrapolation of efficacy from adult studies in those few cases where the disease is similar, inclusion of adolescent patients in adult trials when possible, and bridging the adult dose to the pediatric dose. An analysis of the recommended phase 2 dose for 40 molecularly targeted agents in pediatric patients provides some insight into current practices. Increased knowledge of tumor biology and efforts to identify and validate molecular targets and genetic abnormalities that drive childhood cancers can lead to increased opportunities for precision medicine in the treatment of pediatric cancers.

show abstract

Skin Cancer Awareness and Sun Protection Behaviors in White Hispanic and White Non-Hispanic High School Students in Miami, Florida

Collado-Mesa²,

et al. 2007

Arch Dermatol

View full text Add to dashboard Cite

Pediatric Melanoma: Risk Factor and Survival Analysis of the Surveillance, Epidemiology and End Results Database

Cited by 328 publications

References 21 publications

Prognostic factors for melanoma in children and adolescents

Prognostic factors for melanoma in children and adolescents

Bridging Adult Experience to Pediatrics in Oncology Drug Development

Skin Cancer Awareness and Sun Protection Behaviors in White Hispanic and White Non-Hispanic High School Students in Miami, Florida

Contact Info

Product

Resources

About